Transcriptional Activation of the Human C-Myc Gene by Simian Virus 40 Large T Antigen without Binding to p53 and RB Proteins in the Transient Expression System

Transcriptional activation of the human c-myc gene by SV40 large T antigen was examined using HepG2 cells by co-transfecting a T antigen expression plasmid with a myc-CAT construct containing the 2.3-kb upstream region from the P1 promoter and the P2 promoter region fused to the CAT gene. T antigen...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-06, Vol.235 (1), p.153-157
Hauptverfasser:	Shimazu, Tsutomu, Takada, Shinako, Ishida, Seiichi, Ueno, Yoshio, Koike, Katsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Polyomavirus Transforming - genetics Antigens, Polyomavirus Transforming - metabolism Chloramphenicol O-Acetyltransferase - genetics Chloramphenicol O-Acetyltransferase - metabolism DNA Replication Gene Dosage Genes, myc - genetics Genes, Reporter Humans Plasmids - genetics Promoter Regions, Genetic - genetics Retinoblastoma Protein - metabolism Ribonucleases - metabolism Sequence Deletion - genetics Simian virus 40 - immunology Transcriptional Activation - genetics Transfection - genetics Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
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