Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation after Vascular Injury
The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon cathete...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1989-07, Vol.245 (4914), p.186-188 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Powell, Jerry S. Clozel, Jean-Paul Rita K. M. Müller Kuhn, Herbert Hefti, Fridolin Hosang, Markus Baumgartner, Hans R. |
| description | The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery. |
| doi_str_mv | 10.1126/science.2526370 |
| format | Article |
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M. Müller ; Kuhn, Herbert ; Hefti, Fridolin ; Hosang, Markus ; Baumgartner, Hans R.</creator><creatorcontrib>Powell, Jerry S. ; Clozel, Jean-Paul ; Rita K. M. Müller ; Kuhn, Herbert ; Hefti, Fridolin ; Hosang, Markus ; Baumgartner, Hans R.</creatorcontrib><description>The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2526370</identifier><identifier>PMID: 2526370</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Angiotensin converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Arteries ; Balloon dilatation ; Balloons ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Blood vessels and receptors ; Carotid arteries ; Catheterization ; Cell Division - drug effects ; Cilazapril ; Circulatory system ; depeptidyl carboxypeptidase I ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Health aspects ; injuries ; Male ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - pathology ; Muscular system ; Neointima ; Physical trauma ; Placebos ; Pyridazines - pharmacology ; Rats ; Vascular system injuries ; Vertebrates: cardiovascular system</subject><ispartof>Science (American Association for the Advancement of Science), 1989-07, Vol.245 (4914), p.186-188</ispartof><rights>Copyright 1989 The American Association for the Advancement of Science</rights><rights>1990 INIST-CNRS</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 14, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c815t-bc67622ad57785bf54a59892ee940db1fc571ece86d8b6e4dd75ce090df0f69b3</citedby><cites>FETCH-LOGICAL-c815t-bc67622ad57785bf54a59892ee940db1fc571ece86d8b6e4dd75ce090df0f69b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1703880$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1703880$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6965777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2526370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Powell, Jerry S.</creatorcontrib><creatorcontrib>Clozel, Jean-Paul</creatorcontrib><creatorcontrib>Rita K. 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In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.</description><subject>Angiotensin converting enzyme</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Arteries</subject><subject>Balloon dilatation</subject><subject>Balloons</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood vessels and receptors</subject><subject>Carotid arteries</subject><subject>Catheterization</subject><subject>Cell Division - drug effects</subject><subject>Cilazapril</subject><subject>Circulatory system</subject><subject>depeptidyl carboxypeptidase I</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>injuries</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Muscular system</subject><subject>Neointima</subject><subject>Physical trauma</subject><subject>Placebos</subject><subject>Pyridazines - pharmacology</subject><subject>Rats</subject><subject>Vascular system injuries</subject><subject>Vertebrates: cardiovascular system</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN00Fv0zAUB_AIgUYZnLmAFBCCA2Sz4yS2j6UapVKhSMCuluO8BFepPWxnonx6PDXaBipalYMlv19eFPv_kuQpRicY59WpVxqMgpO8zCtC0b1kghEvM54jcj-ZIESqjCFaPkweeb9GKNY4OUqORj5J6oX5oWsdrPOpbdOp6bQNYLw22cyaS3BBmy49M7-3G0i_OLgEE9JPW6tN0BvZxy3b6xacDNqaVLYBXHouvRp66dKFWQ9u-zh50Mrew5NxPU6-fzj7NvuYLVfzxWy6zBTDZchqVdEqz2VTUsrKui0LWXLGcwBeoKbGrSopBgWsalhdQdE0tFSAOGpa1Fa8JsfJ613fC2d_DuCD2GivoO-lATt4QTniBDF8JyRVwUle5HdCXBJMMSERvvwHru3gTPxbkWNSFghjFtGLHepkD0Kb1gYn1VVHMaUM55TzaN7uMR2YeMK9NdDquH1Lv9uj49PARqs9_M1fPIoAv0InB-_F4uvnQ-Xq_FD5fn6gZPPl_w9hlMr2PXQgYmhmq9v6dKeVs947aMWFi9F0W4GRuJoRMc6IGEMf33g-3tZQb6C59jf1V2M9Bln2rZNGaX_NKl7FiNLInu3Y2sfxuflq7MAYIn8Ay9EgWg</recordid><startdate>19890714</startdate><enddate>19890714</enddate><creator>Powell, Jerry S.</creator><creator>Clozel, Jean-Paul</creator><creator>Rita K. 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Psychology</topic><topic>Health aspects</topic><topic>injuries</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Muscular system</topic><topic>Neointima</topic><topic>Physical trauma</topic><topic>Placebos</topic><topic>Pyridazines - pharmacology</topic><topic>Rats</topic><topic>Vascular system injuries</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powell, Jerry S.</creatorcontrib><creatorcontrib>Clozel, Jean-Paul</creatorcontrib><creatorcontrib>Rita K. M. 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powell, Jerry S.</au><au>Clozel, Jean-Paul</au><au>Rita K. 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In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2526370</pmid><doi>10.1126/science.2526370</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1989-07, Vol.245 (4914), p.186-188 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79093081 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Angiotensin converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Arteries Balloon dilatation Balloons Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood vessels and receptors Carotid arteries Catheterization Cell Division - drug effects Cilazapril Circulatory system depeptidyl carboxypeptidase I Enzymes Fundamental and applied biological sciences. Psychology Health aspects injuries Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Muscular system Neointima Physical trauma Placebos Pyridazines - pharmacology Rats Vascular system injuries Vertebrates: cardiovascular system |
| title | Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation after Vascular Injury |
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