K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells

K‐252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits, in a dose‐ and time‐dependent fashion, the increased transcription of the protooncogene c‐fos induced by nerve growth factor in PC12 cells. Induction of c‐fos by epidermal growth factor, A23187, dBc...

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Veröffentlicht in:	Journal of neuroscience research 1989-05, Vol.23 (1), p.1-8
Hauptverfasser:	Lazarovici, P., Levi, B.-Z., Lelkes, P. I., Koizumi, S., Fujita, K., Matsuda, Y., Ozato, K., Guroff, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms Animals calcium Calcium - metabolism Carbazoles - pharmacology Cell Line DNA-Binding Proteins - genetics fura-2 Indole Alkaloids kinase inhibitor Nerve Growth Factors - pharmacology Nucleic Acid Hybridization Pheochromocytoma Protein Kinase C - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-fos Proto-Oncogenes - drug effects RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Transcription, Genetic - drug effects
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