Molecular Mechanism and Functional Significance of the MinK Control of the KvLQT1 Channel Activity

The very slowly activating delayed rectifier K+ channel IKs is essential for controlling the repolarization phase of cardiac action potentials and K+ homeostasis in the inner ear. The IKschannel is formed via the assembly of two transmembrane proteins, KvLQT1 and MinK. Mutations in KvLQT1 are associ...

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Veröffentlicht in:	The Journal of biological chemistry 1997-07, Vol.272 (27), p.16713-16716
Hauptverfasser:	Romey, Georges, Attali, Bernard, Chouabe, Christophe, Abitbol, Ilane, Guillemare, Eric, Barhanin, Jacques, Lazdunski, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals COS Cells KCNQ Potassium Channels KCNQ1 Potassium Channel Kinetics Models, Molecular Myocardium - metabolism Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Voltage-Gated Protein Binding Transfection
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