Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia

Serum levels of the vitamin D metabolites 25‐hydroxyvitamin D, 24,25‐dihydroxyvitamin D, and 1,25‐dihydroxyvitamin D. and of osteocalcin. C‐tenninal parathyroid hormone and other biochemical indices related to bone metabolism, were determined in two groups of patients with β‐thalassaemia aged 5–10 y...

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Veröffentlicht in:Acta Paediatrica 1997-06, Vol.86 (6), p.594-599
Hauptverfasser: Moulas, A, Challa, A, Chaliasos, N, Lapatsanis, PD
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description Serum levels of the vitamin D metabolites 25‐hydroxyvitamin D, 24,25‐dihydroxyvitamin D, and 1,25‐dihydroxyvitamin D. and of osteocalcin. C‐tenninal parathyroid hormone and other biochemical indices related to bone metabolism, were determined in two groups of patients with β‐thalassaemia aged 5–10 years (summer 7.8 ± 0.4 years, mean ± SEM. and winter 7.7 ± 0.4 years, group A, n= 15) and 11–23 years (16.6 ± 0.9 and 15.7 ± 0.9 years in summer and winter, respectively, group B, n= 22). Emphasis was given to populations of school and adolescent ages and to the seasons of summer and winter when vitamin D status demonstrates the widest extremes. The mean serum levels of 25‐hydroxyvitamin D in patients aged 5–10 years did not differ from those of controls during both seasons studied. In contrast, in the age group 11–23 years these levels were found to be lower in patients than in controls both in winter (10.6 ± 0.9ng/ml vs 15.0 ± 2.0ng/ml, p < 0.05) and summer (20.2 ± 2.1 ng/ml vs 27.1 ± 2.0ng/ml, p < 0.05). The serum concentrations of 24,25‐dihydroxyvitamin D were lower in the thalassaemic patients than in controls in both age groups and both seasons. In the patients under 10 years of age the mean values of this metabolite in winter were 1.06 ± 0.17 ng/ml vs 1.68 ± 0.20 ng/ml in the respective controls (p < 0.05), and in summer 1.44 ± 0.11 ng/ml vs 2.35 ± 0.36 ng/ml in controls (p < 0.05). In the group of patients aged 11–23 years, the mean levels of 24,25‐dihydroxyvitamin D were in winter 0.65 ± 0.12 ng/ml vs 1.12 ± 0.19 ng/ml (p < 0.05) in controls and in summer 1.34 ± 0.12 ng/ml vs 1.84 ± 0.20 ng/ml (p < 0.05). The 1,25‐dihydroxyvitamin D concentrations in both thalassaemic patient groups were significantly no different from those in the respective control groups. Serum osteocalcin, C‐terminal parathyroid hormone, calcium, inorganic phosphate and alkaline phosphatase levels in the patients studied were not significantly different from those in controls, except for calcium and phosphate in the older group. In the older group of thalassaemic patients, serum calcium was lower than in the controls (2.26 ± 0.03 vs 2.37 ± 0.03 mmol/1, p < 0.05) in summer and serum phosphate higher than in the controls in winter (1.47 ± 0.05 mmol/1 vs 1.27 ± 0.06 mmol/1. p < 0.05).
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C‐tenninal parathyroid hormone and other biochemical indices related to bone metabolism, were determined in two groups of patients with β‐thalassaemia aged 5–10 years (summer 7.8 ± 0.4 years, mean ± SEM. and winter 7.7 ± 0.4 years, group A, n= 15) and 11–23 years (16.6 ± 0.9 and 15.7 ± 0.9 years in summer and winter, respectively, group B, n= 22). Emphasis was given to populations of school and adolescent ages and to the seasons of summer and winter when vitamin D status demonstrates the widest extremes. The mean serum levels of 25‐hydroxyvitamin D in patients aged 5–10 years did not differ from those of controls during both seasons studied. In contrast, in the age group 11–23 years these levels were found to be lower in patients than in controls both in winter (10.6 ± 0.9ng/ml vs 15.0 ± 2.0ng/ml, p < 0.05) and summer (20.2 ± 2.1 ng/ml vs 27.1 ± 2.0ng/ml, p < 0.05). The serum concentrations of 24,25‐dihydroxyvitamin D were lower in the thalassaemic patients than in controls in both age groups and both seasons. In the patients under 10 years of age the mean values of this metabolite in winter were 1.06 ± 0.17 ng/ml vs 1.68 ± 0.20 ng/ml in the respective controls (p < 0.05), and in summer 1.44 ± 0.11 ng/ml vs 2.35 ± 0.36 ng/ml in controls (p < 0.05). In the group of patients aged 11–23 years, the mean levels of 24,25‐dihydroxyvitamin D were in winter 0.65 ± 0.12 ng/ml vs 1.12 ± 0.19 ng/ml (p < 0.05) in controls and in summer 1.34 ± 0.12 ng/ml vs 1.84 ± 0.20 ng/ml (p < 0.05). The 1,25‐dihydroxyvitamin D concentrations in both thalassaemic patient groups were significantly no different from those in the respective control groups. Serum osteocalcin, C‐terminal parathyroid hormone, calcium, inorganic phosphate and alkaline phosphatase levels in the patients studied were not significantly different from those in controls, except for calcium and phosphate in the older group. In the older group of thalassaemic patients, serum calcium was lower than in the controls (2.26 ± 0.03 vs 2.37 ± 0.03 mmol/1, p < 0.05) in summer and serum phosphate higher than in the controls in winter (1.47 ± 0.05 mmol/1 vs 1.27 ± 0.06 mmol/1. p < 0.05).]]></description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.1997.tb08940.x</identifier><identifier>PMID: 9202793</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>24,25-Dihydroxyvitamin D 3 - blood ; Adolescent ; Adult ; Age Factors ; Anemias. Hemoglobinopathies ; beta-Thalassemia - blood ; Biological and medical sciences ; Body Weight ; Child ; Child, Preschool ; Cholecalciferol ; Diseases of red blood cells ; Hematologic and hematopoietic diseases ; Humans ; Hydroxylation ; Medical sciences ; osteocalcin ; Osteocalcin - blood ; Seasons ; Vitamin D - analogs &amp; derivatives ; Vitamin D - blood ; Vitamin D - metabolism ; β-thalassaemia</subject><ispartof>Acta Paediatrica, 1997-06, Vol.86 (6), p.594-599</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4364-6964be9d6fe9d2355b30f675a723c607b0a70a0edc64902b60c121a551fca5bc3</citedby><cites>FETCH-LOGICAL-c4364-6964be9d6fe9d2355b30f675a723c607b0a70a0edc64902b60c121a551fca5bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.1997.tb08940.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.1997.tb08940.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2704880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9202793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moulas, A</creatorcontrib><creatorcontrib>Challa, A</creatorcontrib><creatorcontrib>Chaliasos, N</creatorcontrib><creatorcontrib>Lapatsanis, PD</creatorcontrib><title>Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description><![CDATA[Serum levels of the vitamin D metabolites 25‐hydroxyvitamin D, 24,25‐dihydroxyvitamin D, and 1,25‐dihydroxyvitamin D. and of osteocalcin. C‐tenninal parathyroid hormone and other biochemical indices related to bone metabolism, were determined in two groups of patients with β‐thalassaemia aged 5–10 years (summer 7.8 ± 0.4 years, mean ± SEM. and winter 7.7 ± 0.4 years, group A, n= 15) and 11–23 years (16.6 ± 0.9 and 15.7 ± 0.9 years in summer and winter, respectively, group B, n= 22). Emphasis was given to populations of school and adolescent ages and to the seasons of summer and winter when vitamin D status demonstrates the widest extremes. The mean serum levels of 25‐hydroxyvitamin D in patients aged 5–10 years did not differ from those of controls during both seasons studied. In contrast, in the age group 11–23 years these levels were found to be lower in patients than in controls both in winter (10.6 ± 0.9ng/ml vs 15.0 ± 2.0ng/ml, p < 0.05) and summer (20.2 ± 2.1 ng/ml vs 27.1 ± 2.0ng/ml, p < 0.05). The serum concentrations of 24,25‐dihydroxyvitamin D were lower in the thalassaemic patients than in controls in both age groups and both seasons. In the patients under 10 years of age the mean values of this metabolite in winter were 1.06 ± 0.17 ng/ml vs 1.68 ± 0.20 ng/ml in the respective controls (p < 0.05), and in summer 1.44 ± 0.11 ng/ml vs 2.35 ± 0.36 ng/ml in controls (p < 0.05). In the group of patients aged 11–23 years, the mean levels of 24,25‐dihydroxyvitamin D were in winter 0.65 ± 0.12 ng/ml vs 1.12 ± 0.19 ng/ml (p < 0.05) in controls and in summer 1.34 ± 0.12 ng/ml vs 1.84 ± 0.20 ng/ml (p < 0.05). The 1,25‐dihydroxyvitamin D concentrations in both thalassaemic patient groups were significantly no different from those in the respective control groups. Serum osteocalcin, C‐terminal parathyroid hormone, calcium, inorganic phosphate and alkaline phosphatase levels in the patients studied were not significantly different from those in controls, except for calcium and phosphate in the older group. In the older group of thalassaemic patients, serum calcium was lower than in the controls (2.26 ± 0.03 vs 2.37 ± 0.03 mmol/1, p < 0.05) in summer and serum phosphate higher than in the controls in winter (1.47 ± 0.05 mmol/1 vs 1.27 ± 0.06 mmol/1. p < 0.05).]]></description><subject>24,25-Dihydroxyvitamin D 3 - blood</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Anemias. Hemoglobinopathies</subject><subject>beta-Thalassemia - blood</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholecalciferol</subject><subject>Diseases of red blood cells</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hydroxylation</subject><subject>Medical sciences</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Seasons</subject><subject>Vitamin D - analogs &amp; derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - metabolism</subject><subject>β-thalassaemia</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkduO0zAQhi0EWkrhEZAihBBImzA-11wglYVdQF0O4nRpTRxH65I0S5xCe88T8SA8Ey4NvUDcYFm2NP8_v61vCLlDoaBpPVwWVEmaM8Z0QY3RxVDCzAgoNlfI5CBdJROYAc8lk_w6uRHjEoBxI9QROTIMmDZ8Qr5_DAO2YZU9zVo_YNk1YfAxu89kfrGt-m6z_frHcJwxcZzqVfhbyXBVZfTf2oPfYhcH3zlsXCql_fNHPlxggzGibwPeJNdqbKK_Nd5T8uH02fuT5_ni9dmLk_kid4IrkSujROlNpep0MC5lyaFWWqJm3CnQJaAGBF85JQywUoGjjKKUtHYoS8en5N4-97Lvvqx9HGwbovNNgyvfraPVJmFMPJPx0d7o-i7G3tf2sg8t9ltLwe5GYJd2x9nuONvdCOw4ArtJzbfHV9Zl66tD68g86XdHHWNCUve4ciEebEyDmKW5Tcnjve1baPz2Pz5g52_m0ogUkO8DQoK_OQRg_9kqzbW0n16dWfn2_PTJ-eKdfcl_Ac4isrU</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>Moulas, A</creator><creator>Challa, A</creator><creator>Chaliasos, N</creator><creator>Lapatsanis, PD</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199706</creationdate><title>Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia</title><author>Moulas, A ; Challa, A ; Chaliasos, N ; Lapatsanis, PD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-6964be9d6fe9d2355b30f675a723c607b0a70a0edc64902b60c121a551fca5bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>24,25-Dihydroxyvitamin D 3 - blood</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Anemias. Hemoglobinopathies</topic><topic>beta-Thalassemia - blood</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholecalciferol</topic><topic>Diseases of red blood cells</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hydroxylation</topic><topic>Medical sciences</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Seasons</topic><topic>Vitamin D - analogs &amp; derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - metabolism</topic><topic>β-thalassaemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moulas, A</creatorcontrib><creatorcontrib>Challa, A</creatorcontrib><creatorcontrib>Chaliasos, N</creatorcontrib><creatorcontrib>Lapatsanis, PD</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moulas, A</au><au>Challa, A</au><au>Chaliasos, N</au><au>Lapatsanis, PD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>1997-06</date><risdate>1997</risdate><volume>86</volume><issue>6</issue><spage>594</spage><epage>599</epage><pages>594-599</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract><![CDATA[Serum levels of the vitamin D metabolites 25‐hydroxyvitamin D, 24,25‐dihydroxyvitamin D, and 1,25‐dihydroxyvitamin D. and of osteocalcin. C‐tenninal parathyroid hormone and other biochemical indices related to bone metabolism, were determined in two groups of patients with β‐thalassaemia aged 5–10 years (summer 7.8 ± 0.4 years, mean ± SEM. and winter 7.7 ± 0.4 years, group A, n= 15) and 11–23 years (16.6 ± 0.9 and 15.7 ± 0.9 years in summer and winter, respectively, group B, n= 22). Emphasis was given to populations of school and adolescent ages and to the seasons of summer and winter when vitamin D status demonstrates the widest extremes. The mean serum levels of 25‐hydroxyvitamin D in patients aged 5–10 years did not differ from those of controls during both seasons studied. In contrast, in the age group 11–23 years these levels were found to be lower in patients than in controls both in winter (10.6 ± 0.9ng/ml vs 15.0 ± 2.0ng/ml, p < 0.05) and summer (20.2 ± 2.1 ng/ml vs 27.1 ± 2.0ng/ml, p < 0.05). The serum concentrations of 24,25‐dihydroxyvitamin D were lower in the thalassaemic patients than in controls in both age groups and both seasons. In the patients under 10 years of age the mean values of this metabolite in winter were 1.06 ± 0.17 ng/ml vs 1.68 ± 0.20 ng/ml in the respective controls (p < 0.05), and in summer 1.44 ± 0.11 ng/ml vs 2.35 ± 0.36 ng/ml in controls (p < 0.05). In the group of patients aged 11–23 years, the mean levels of 24,25‐dihydroxyvitamin D were in winter 0.65 ± 0.12 ng/ml vs 1.12 ± 0.19 ng/ml (p < 0.05) in controls and in summer 1.34 ± 0.12 ng/ml vs 1.84 ± 0.20 ng/ml (p < 0.05). The 1,25‐dihydroxyvitamin D concentrations in both thalassaemic patient groups were significantly no different from those in the respective control groups. Serum osteocalcin, C‐terminal parathyroid hormone, calcium, inorganic phosphate and alkaline phosphatase levels in the patients studied were not significantly different from those in controls, except for calcium and phosphate in the older group. In the older group of thalassaemic patients, serum calcium was lower than in the controls (2.26 ± 0.03 vs 2.37 ± 0.03 mmol/1, p < 0.05) in summer and serum phosphate higher than in the controls in winter (1.47 ± 0.05 mmol/1 vs 1.27 ± 0.06 mmol/1. p < 0.05).]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9202793</pmid><doi>10.1111/j.1651-2227.1997.tb08940.x</doi><tpages>6</tpages></addata></record>
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subjects 24,25-Dihydroxyvitamin D 3 - blood
Adolescent
Adult
Age Factors
Anemias. Hemoglobinopathies
beta-Thalassemia - blood
Biological and medical sciences
Body Weight
Child
Child, Preschool
Cholecalciferol
Diseases of red blood cells
Hematologic and hematopoietic diseases
Humans
Hydroxylation
Medical sciences
osteocalcin
Osteocalcin - blood
Seasons
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - metabolism
β-thalassaemia
title Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia
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