IL-2, a lectin with specificity for high mannose glycopeptides

Utilizing a solid phase binding assay, we have demonstrated that rIL-2 binds with high affinity to the human urinary glycoprotein uromodulin. This binding is specifically inhibited by the saccharides diacetylchitobiose and Man(alpha 1-3)(Man(alpha 1-6]Man-O-methyl and by the high mannose glycopeptid...

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Veröffentlicht in:	The Journal of immunology (1950) 1989-08, Vol.143 (3), p.939-944
Hauptverfasser:	Sherblom, AP, Sathyamoorthy, N, Decker, JM, Muchmore, AV
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding, Competitive Carbohydrate Sequence Carrier Proteins - isolation & purification Carrier Proteins - metabolism Female Glycopeptides - metabolism Glycopeptides - pharmacology Humans Hydrogen-Ion Concentration Interleukin-2 - metabolism Lectins - metabolism Mannose - metabolism Mannose - pharmacology Mannose-Binding Lectins Molecular Sequence Data Mucoproteins - metabolism Oligosaccharides - pharmacology Pregnancy Receptors, Interleukin-2 - metabolism Recombinant Proteins - metabolism Uromodulin
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