Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia
It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia. This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in t...
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| Veröffentlicht in: | Folia Pharmacologica Japonica 1989, Vol.93(4), pp.255-260 |
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| creator | GOTO, Kazuhiro SUEKAWA, Mamoru HOSOYA, Eikichi |
| description | It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia. This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in the cumulative mortality rate after ligation of the bilateral carotid artery (BCA) in mice. TJ-8007 also significantly prolonged the survival time at the dose of 3.0 g/kg, p.o. However, TJ-8007 (1.0 or 3.0 g/kg, p.o.) did not affect the mean survival time after ligation of BCA in Mongolian gerbils and the gasping movement in a decapitated mouse head that served as a complete ischemic model. Ifenprodil (30 mg/kg, p.o.) also showed the protective effect only against ischemic death after ligation of BCA in mice. TJ-8007 (1.0 or 3.0 g/kg, p.o.) increased the vertebral blood flow, but showed no effect on the internal carotid blood flow in anesthetized dogs. These results suggest that the mechanism for the cerebral protective effect of TJ-8007 may be due to its ameliorating action on the cerebral circulation. |
| doi_str_mv | 10.1254/fpj.93.255 |
| format | Article |
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This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in the cumulative mortality rate after ligation of the bilateral carotid artery (BCA) in mice. TJ-8007 also significantly prolonged the survival time at the dose of 3.0 g/kg, p.o. However, TJ-8007 (1.0 or 3.0 g/kg, p.o.) did not affect the mean survival time after ligation of BCA in Mongolian gerbils and the gasping movement in a decapitated mouse head that served as a complete ischemic model. Ifenprodil (30 mg/kg, p.o.) also showed the protective effect only against ischemic death after ligation of BCA in mice. TJ-8007 (1.0 or 3.0 g/kg, p.o.) increased the vertebral blood flow, but showed no effect on the internal carotid blood flow in anesthetized dogs. These results suggest that the mechanism for the cerebral protective effect of TJ-8007 may be due to its ameliorating action on the cerebral circulation.</description><identifier>ISSN: 0015-5691</identifier><identifier>EISSN: 1347-8397</identifier><identifier>DOI: 10.1254/fpj.93.255</identifier><identifier>PMID: 2744655</identifier><language>jpn</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Animals ; Brain Ischemia - drug therapy ; Carotid Artery, Internal - physiology ; Dogs ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Female ; Gerbillinae ; Male ; Mice ; Piperidines - pharmacology ; Piperidines - therapeutic use ; Regional Blood Flow - drug effects ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use ; Vertebral Artery - physiology</subject><ispartof>Folia Pharmacologica Japonica, 1989, Vol.93(4), pp.255-260</ispartof><rights>The Japanese PharmacologicalSociety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3815-a3f2ad3487755266e53bfa82037adb98961b3f99e4ea49a8ea1e63bb06cf45133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2744655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOTO, Kazuhiro</creatorcontrib><creatorcontrib>SUEKAWA, Mamoru</creatorcontrib><creatorcontrib>HOSOYA, Eikichi</creatorcontrib><title>Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia</title><title>Folia Pharmacologica Japonica</title><addtitle>Nihon Yakurigaku Zasshi</addtitle><description>It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia. This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in the cumulative mortality rate after ligation of the bilateral carotid artery (BCA) in mice. TJ-8007 also significantly prolonged the survival time at the dose of 3.0 g/kg, p.o. However, TJ-8007 (1.0 or 3.0 g/kg, p.o.) did not affect the mean survival time after ligation of BCA in Mongolian gerbils and the gasping movement in a decapitated mouse head that served as a complete ischemic model. Ifenprodil (30 mg/kg, p.o.) also showed the protective effect only against ischemic death after ligation of BCA in mice. TJ-8007 (1.0 or 3.0 g/kg, p.o.) increased the vertebral blood flow, but showed no effect on the internal carotid blood flow in anesthetized dogs. These results suggest that the mechanism for the cerebral protective effect of TJ-8007 may be due to its ameliorating action on the cerebral circulation.</description><subject>Animals</subject><subject>Brain Ischemia - drug therapy</subject><subject>Carotid Artery, Internal - physiology</subject><subject>Dogs</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Gerbillinae</subject><subject>Male</subject><subject>Mice</subject><subject>Piperidines - pharmacology</subject><subject>Piperidines - therapeutic use</subject><subject>Regional Blood Flow - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Vertebral Artery - physiology</subject><issn>0015-5691</issn><issn>1347-8397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrGzEURkVpSU2STfeFWZWkMI40encXTB8OgWbhbLoZ7shXjtIZy5FmCvn3lbEx3XUjCb6jw-V-hHxgdM4aKW787nlu-byR8g2ZMS50bbjVb8mMUiZrqSx7Ty5zDh2lUjdacXZGzhothJJyRl4eniAN4GIfN8FBX-VxWr9W0Veru9pQqqurVZ6GKUH9K_6eBgxjvK6ulsvrL9VDiiO6MfzBCr0vr3-_wQbCNo-Vw4RdKuKQ3RMOAS7IOw99xsvjfU4ev31dLX7U9z-_Lxe397XjpgwO3Dew5sJoLWWjFEreeTAN5RrWnTVWsY57a1EgCAsGgaHiXUeV80Iyzs_Jp4N3l-LLhHlshzIC9j1sMU651ZYaI5T6L8hkY6RWtoCfD6BLMeeEvt2lMEB6bRlt9120pYvW8rZ0UeCPR-vUDbg-ocfNl3xxyJ_zCBs85ZDG4Hrcq5gVYq87HsV6Sl1prcUt_wv1Npo5</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>GOTO, Kazuhiro</creator><creator>SUEKAWA, Mamoru</creator><creator>HOSOYA, Eikichi</creator><general>The Japanese Pharmacological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia</title><author>GOTO, Kazuhiro ; SUEKAWA, Mamoru ; HOSOYA, Eikichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3815-a3f2ad3487755266e53bfa82037adb98961b3f99e4ea49a8ea1e63bb06cf45133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Brain Ischemia - drug therapy</topic><topic>Carotid Artery, Internal - physiology</topic><topic>Dogs</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>Gerbillinae</topic><topic>Male</topic><topic>Mice</topic><topic>Piperidines - pharmacology</topic><topic>Piperidines - therapeutic use</topic><topic>Regional Blood Flow - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Vertebral Artery - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOTO, Kazuhiro</creatorcontrib><creatorcontrib>SUEKAWA, Mamoru</creatorcontrib><creatorcontrib>HOSOYA, Eikichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Folia Pharmacologica Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOTO, Kazuhiro</au><au>SUEKAWA, Mamoru</au><au>HOSOYA, Eikichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia</atitle><jtitle>Folia Pharmacologica Japonica</jtitle><addtitle>Nihon Yakurigaku Zasshi</addtitle><date>1989</date><risdate>1989</risdate><volume>93</volume><issue>4</issue><spage>255</spage><epage>260</epage><pages>255-260</pages><issn>0015-5691</issn><eissn>1347-8397</eissn><abstract>It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia. This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in the cumulative mortality rate after ligation of the bilateral carotid artery (BCA) in mice. TJ-8007 also significantly prolonged the survival time at the dose of 3.0 g/kg, p.o. However, TJ-8007 (1.0 or 3.0 g/kg, p.o.) did not affect the mean survival time after ligation of BCA in Mongolian gerbils and the gasping movement in a decapitated mouse head that served as a complete ischemic model. Ifenprodil (30 mg/kg, p.o.) also showed the protective effect only against ischemic death after ligation of BCA in mice. TJ-8007 (1.0 or 3.0 g/kg, p.o.) increased the vertebral blood flow, but showed no effect on the internal carotid blood flow in anesthetized dogs. These results suggest that the mechanism for the cerebral protective effect of TJ-8007 may be due to its ameliorating action on the cerebral circulation.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>2744655</pmid><doi>10.1254/fpj.93.255</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia Pharmacologica Japonica, 1989, Vol.93(4), pp.255-260 |
| issn | 0015-5691 1347-8397 |
| language | jpn |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Animals Brain Ischemia - drug therapy Carotid Artery, Internal - physiology Dogs Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Gerbillinae Male Mice Piperidines - pharmacology Piperidines - therapeutic use Regional Blood Flow - drug effects Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Vertebral Artery - physiology |
| title | Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia |
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