Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy?
Background: The aim of this study was to prospectively compare the diagnostic accuracy of videoendoscopy, with and without Lugol staining, for the detection of esophageal cancer in alcoholic or smoking patients older than 40 years. Methods: Daily alcohol and tobacco consumption and overt and latent...
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| Veröffentlicht in: | Gastrointestinal endoscopy 1997-06, Vol.45 (6), p.480-484 |
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| creator | Meyer, Véronique Burtin, Pascal Bour, Bruno Blanchi, Alain Cales, Paul Oberti, Frédéric Person, Bruno Croue, Anne Dohn, Sylvie Benoit, Roland Fabiani, Bettina Boyer, Jean |
| description | Background: The aim of this study was to prospectively compare the diagnostic accuracy of videoendoscopy, with and without Lugol staining, for the detection of esophageal cancer in alcoholic or smoking patients older than 40 years.
Methods: Daily alcohol and tobacco consumption and overt and latent symptoms were noted. The 158 patients included were examined by videoendoscopy and with Lugol dye.
Results: The mean consumption of alcohol and tobacco was 86 ± 49 gm/day for 26 ± 11 years, and 30 ± 18 pack-years, respectively. Twenty-five patients had no symptoms. Before Lugol staining, 12 patients had endoscopically identified cancerous lesions. After Lugol staining, 13 patients had 17 esophageal cancers, 3 of which were high-grade dysplasia. The prevalence of esophageal cancer was 8.2%: 95% CI [4,14]. Dye-free surfaces were significantly larger than the endoscopic patterns observed before Lugol staining (11.6 ± 9.2 cm
2 vs 1.4 ± 1.7 cm
2;
p < 0.02).
Conclusions: In an alcoholic smoking population, the prevalence of esophageal cancer detected by endoscopy is high and not related to symptoms described by patients. Lugol staining only moderately improves the diagnostic accuracy of videoendoscopy; its main advantage is the assessment of the mucosal extension of esophageal cancer. (Gastrointest Endosc 1997;45:480-4.) |
| doi_str_mv | 10.1016/S0016-5107(97)70177-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79088364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0016510797701779</els_id><sourcerecordid>79088364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-68a4621bf696c45828e0c7914ba90be3d886296d381ecee3414a6c8ee00ec553</originalsourceid><addsrcrecordid>eNqFkU1rGzEQhkVoSZw0PyGgQyjtYdvRfugjl1BC0gQMPTR3IUuzttr1aiPtGvzvK8eLr71IoHlezfAMITcMvjFg_PtvyGfRMBBflPgqgAlRqDOyYKBEwYVQH8jihFyQy5T-AIAsK3ZOzhVTSkG9ILvH3oVkw-AtdTiiHX3oaWgpmtjtKaYwbMwaTUet6S1G6ntq6MavN0X06S8dwjB15hC6oy5gostpHTqaRuN736-p3w4x7JDuvMOAc6_9_SfysTVdwuv5viKvT4-vD8_F8tfPl4cfy8LWTTMWXJqal2zVcsXziywlghWK1SujYIWVk5KXirtKMrSIVc1qw61EBEDbNNUV-Xz8Ng_xNmEa9dYni11negxT0kKBlBWvM9gcQRtDShFbPUS_NXGvGeiDbv2uWx9caiX0u26tcu5mbjCttuhOqdlvrt_OdZOs6dqYJfp0wkoBPG8kY_dHDLOLnceok_WYfTsf80q0C_4_g_wDH2ad0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79088364</pqid></control><display><type>article</type><title>Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Meyer, Véronique ; Burtin, Pascal ; Bour, Bruno ; Blanchi, Alain ; Cales, Paul ; Oberti, Frédéric ; Person, Bruno ; Croue, Anne ; Dohn, Sylvie ; Benoit, Roland ; Fabiani, Bettina ; Boyer, Jean</creator><creatorcontrib>Meyer, Véronique ; Burtin, Pascal ; Bour, Bruno ; Blanchi, Alain ; Cales, Paul ; Oberti, Frédéric ; Person, Bruno ; Croue, Anne ; Dohn, Sylvie ; Benoit, Roland ; Fabiani, Bettina ; Boyer, Jean</creatorcontrib><description>Background: The aim of this study was to prospectively compare the diagnostic accuracy of videoendoscopy, with and without Lugol staining, for the detection of esophageal cancer in alcoholic or smoking patients older than 40 years.
Methods: Daily alcohol and tobacco consumption and overt and latent symptoms were noted. The 158 patients included were examined by videoendoscopy and with Lugol dye.
Results: The mean consumption of alcohol and tobacco was 86 ± 49 gm/day for 26 ± 11 years, and 30 ± 18 pack-years, respectively. Twenty-five patients had no symptoms. Before Lugol staining, 12 patients had endoscopically identified cancerous lesions. After Lugol staining, 13 patients had 17 esophageal cancers, 3 of which were high-grade dysplasia. The prevalence of esophageal cancer was 8.2%: 95% CI [4,14]. Dye-free surfaces were significantly larger than the endoscopic patterns observed before Lugol staining (11.6 ± 9.2 cm
2 vs 1.4 ± 1.7 cm
2;
p < 0.02).
Conclusions: In an alcoholic smoking population, the prevalence of esophageal cancer detected by endoscopy is high and not related to symptoms described by patients. Lugol staining only moderately improves the diagnostic accuracy of videoendoscopy; its main advantage is the assessment of the mucosal extension of esophageal cancer. (Gastrointest Endosc 1997;45:480-4.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/S0016-5107(97)70177-9</identifier><identifier>PMID: 9199904</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Biopsy ; Carcinoma - diagnostic imaging ; Carcinoma - epidemiology ; Carcinoma - pathology ; Coloring Agents ; Digestive system. Abdomen ; Endoscopy ; Endoscopy, Digestive System - methods ; Endosonography - methods ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - pathology ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Iodides ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; Smoking - adverse effects ; Video Recording - methods</subject><ispartof>Gastrointestinal endoscopy, 1997-06, Vol.45 (6), p.480-484</ispartof><rights>1998 American Association of Orthodontists</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-68a4621bf696c45828e0c7914ba90be3d886296d381ecee3414a6c8ee00ec553</citedby><cites>FETCH-LOGICAL-c455t-68a4621bf696c45828e0c7914ba90be3d886296d381ecee3414a6c8ee00ec553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016510797701779$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2706823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9199904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyer, Véronique</creatorcontrib><creatorcontrib>Burtin, Pascal</creatorcontrib><creatorcontrib>Bour, Bruno</creatorcontrib><creatorcontrib>Blanchi, Alain</creatorcontrib><creatorcontrib>Cales, Paul</creatorcontrib><creatorcontrib>Oberti, Frédéric</creatorcontrib><creatorcontrib>Person, Bruno</creatorcontrib><creatorcontrib>Croue, Anne</creatorcontrib><creatorcontrib>Dohn, Sylvie</creatorcontrib><creatorcontrib>Benoit, Roland</creatorcontrib><creatorcontrib>Fabiani, Bettina</creatorcontrib><creatorcontrib>Boyer, Jean</creatorcontrib><title>Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy?</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: The aim of this study was to prospectively compare the diagnostic accuracy of videoendoscopy, with and without Lugol staining, for the detection of esophageal cancer in alcoholic or smoking patients older than 40 years.
Methods: Daily alcohol and tobacco consumption and overt and latent symptoms were noted. The 158 patients included were examined by videoendoscopy and with Lugol dye.
Results: The mean consumption of alcohol and tobacco was 86 ± 49 gm/day for 26 ± 11 years, and 30 ± 18 pack-years, respectively. Twenty-five patients had no symptoms. Before Lugol staining, 12 patients had endoscopically identified cancerous lesions. After Lugol staining, 13 patients had 17 esophageal cancers, 3 of which were high-grade dysplasia. The prevalence of esophageal cancer was 8.2%: 95% CI [4,14]. Dye-free surfaces were significantly larger than the endoscopic patterns observed before Lugol staining (11.6 ± 9.2 cm
2 vs 1.4 ± 1.7 cm
2;
p < 0.02).
Conclusions: In an alcoholic smoking population, the prevalence of esophageal cancer detected by endoscopy is high and not related to symptoms described by patients. Lugol staining only moderately improves the diagnostic accuracy of videoendoscopy; its main advantage is the assessment of the mucosal extension of esophageal cancer. (Gastrointest Endosc 1997;45:480-4.)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - pathology</subject><subject>Coloring Agents</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Endoscopy, Digestive System - methods</subject><subject>Endosonography - methods</subject><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodides</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Video Recording - methods</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVoSZw0PyGgQyjtYdvRfugjl1BC0gQMPTR3IUuzttr1aiPtGvzvK8eLr71IoHlezfAMITcMvjFg_PtvyGfRMBBflPgqgAlRqDOyYKBEwYVQH8jihFyQy5T-AIAsK3ZOzhVTSkG9ILvH3oVkw-AtdTiiHX3oaWgpmtjtKaYwbMwaTUet6S1G6ntq6MavN0X06S8dwjB15hC6oy5gostpHTqaRuN736-p3w4x7JDuvMOAc6_9_SfysTVdwuv5viKvT4-vD8_F8tfPl4cfy8LWTTMWXJqal2zVcsXziywlghWK1SujYIWVk5KXirtKMrSIVc1qw61EBEDbNNUV-Xz8Ng_xNmEa9dYni11negxT0kKBlBWvM9gcQRtDShFbPUS_NXGvGeiDbv2uWx9caiX0u26tcu5mbjCttuhOqdlvrt_OdZOs6dqYJfp0wkoBPG8kY_dHDLOLnceok_WYfTsf80q0C_4_g_wDH2ad0Q</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Meyer, Véronique</creator><creator>Burtin, Pascal</creator><creator>Bour, Bruno</creator><creator>Blanchi, Alain</creator><creator>Cales, Paul</creator><creator>Oberti, Frédéric</creator><creator>Person, Bruno</creator><creator>Croue, Anne</creator><creator>Dohn, Sylvie</creator><creator>Benoit, Roland</creator><creator>Fabiani, Bettina</creator><creator>Boyer, Jean</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy?</title><author>Meyer, Véronique ; Burtin, Pascal ; Bour, Bruno ; Blanchi, Alain ; Cales, Paul ; Oberti, Frédéric ; Person, Bruno ; Croue, Anne ; Dohn, Sylvie ; Benoit, Roland ; Fabiani, Bettina ; Boyer, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-68a4621bf696c45828e0c7914ba90be3d886296d381ecee3414a6c8ee00ec553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - epidemiology</topic><topic>Carcinoma - pathology</topic><topic>Coloring Agents</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Endoscopy, Digestive System - methods</topic><topic>Endosonography - methods</topic><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodides</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Video Recording - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer, Véronique</creatorcontrib><creatorcontrib>Burtin, Pascal</creatorcontrib><creatorcontrib>Bour, Bruno</creatorcontrib><creatorcontrib>Blanchi, Alain</creatorcontrib><creatorcontrib>Cales, Paul</creatorcontrib><creatorcontrib>Oberti, Frédéric</creatorcontrib><creatorcontrib>Person, Bruno</creatorcontrib><creatorcontrib>Croue, Anne</creatorcontrib><creatorcontrib>Dohn, Sylvie</creatorcontrib><creatorcontrib>Benoit, Roland</creatorcontrib><creatorcontrib>Fabiani, Bettina</creatorcontrib><creatorcontrib>Boyer, Jean</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer, Véronique</au><au>Burtin, Pascal</au><au>Bour, Bruno</au><au>Blanchi, Alain</au><au>Cales, Paul</au><au>Oberti, Frédéric</au><au>Person, Bruno</au><au>Croue, Anne</au><au>Dohn, Sylvie</au><au>Benoit, Roland</au><au>Fabiani, Bettina</au><au>Boyer, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy?</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>45</volume><issue>6</issue><spage>480</spage><epage>484</epage><pages>480-484</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: The aim of this study was to prospectively compare the diagnostic accuracy of videoendoscopy, with and without Lugol staining, for the detection of esophageal cancer in alcoholic or smoking patients older than 40 years.
Methods: Daily alcohol and tobacco consumption and overt and latent symptoms were noted. The 158 patients included were examined by videoendoscopy and with Lugol dye.
Results: The mean consumption of alcohol and tobacco was 86 ± 49 gm/day for 26 ± 11 years, and 30 ± 18 pack-years, respectively. Twenty-five patients had no symptoms. Before Lugol staining, 12 patients had endoscopically identified cancerous lesions. After Lugol staining, 13 patients had 17 esophageal cancers, 3 of which were high-grade dysplasia. The prevalence of esophageal cancer was 8.2%: 95% CI [4,14]. Dye-free surfaces were significantly larger than the endoscopic patterns observed before Lugol staining (11.6 ± 9.2 cm
2 vs 1.4 ± 1.7 cm
2;
p < 0.02).
Conclusions: In an alcoholic smoking population, the prevalence of esophageal cancer detected by endoscopy is high and not related to symptoms described by patients. Lugol staining only moderately improves the diagnostic accuracy of videoendoscopy; its main advantage is the assessment of the mucosal extension of esophageal cancer. (Gastrointest Endosc 1997;45:480-4.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9199904</pmid><doi>10.1016/S0016-5107(97)70177-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Alcohol Drinking - adverse effects Biological and medical sciences Biopsy Carcinoma - diagnostic imaging Carcinoma - epidemiology Carcinoma - pathology Coloring Agents Digestive system. Abdomen Endoscopy Endoscopy, Digestive System - methods Endosonography - methods Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - epidemiology Esophageal Neoplasms - pathology Female Humans Investigative techniques, diagnostic techniques (general aspects) Iodides Male Medical sciences Middle Aged Prevalence Prospective Studies Risk Factors Smoking - adverse effects Video Recording - methods |
| title | Endoscopic detection of early esophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy? |
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