Interaction of Atrial Natriuretic Peptide and Amiloride on Renal Hemodynamics Through Renal Kallikrein and Kinins in Anesthetized Rabbits
We investigated the interaction of atrial natriuretic peptide (ANP) and amiloride on renal function and the renal kallikrein-kinin system in anesthetized rabbits. The infusion of ANP alone (50 ng/kg/min) induced a natriuretic action with increments in renal blood flow (RBF) and creatinine clearance...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1989-01, Vol.13 Suppl 6, p.S39-S42 |
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| container_end_page | S42 |
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| container_title | Journal of cardiovascular pharmacology |
| container_volume | 13 Suppl 6 |
| creator | Seino, Masahide Abe, Keishi Nushiro, Noboru Omata, Ken Yoshinaga, Kaoru |
| description | We investigated the interaction of atrial natriuretic peptide (ANP) and amiloride on renal function and the renal kallikrein-kinin system in anesthetized rabbits. The infusion of ANP alone (50 ng/kg/min) induced a natriuretic action with increments in renal blood flow (RBF) and creatinine clearance (Ccr). The infusion of ANP with amiloride (5 mg/kg + 0.04 mg/kg/min) produced a further increase in natriuresis despite the absence of an increase in RBF and Ccr induced by ANP alone. The urinary excretion of kallikrein and kinins was increased by the administration of ANP. However, the pretreatment with amiloride prevented the increase in the urinary excretion of kallikrein and kinins induced by ANP. These results suggest that the additive effect on sodium excretion might be attributable to changes in the tubular handling of sodium, although ANP did not modify the distal tubular function on sodium reabsorption. It is also suggested that the renal kallikrein-kinin system is not causally involved in the increased sodium excretion by ANP. |
| doi_str_mv | 10.1097/00005344-198905006-00012 |
| format | Article |
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It is also suggested that the renal kallikrein-kinin system is not causally involved in the increased sodium excretion by ANP.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198905006-00012</identifier><identifier>PMID: 2473347</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Amiloride - pharmacology ; Anesthesia ; Animals ; Atrial Natriuretic Factor - pharmacology ; Blood Pressure - drug effects ; Creatinine - blood ; Female ; Kallikreins - blood ; Kallikreins - metabolism ; Kallikreins - urine ; Kidney - drug effects ; Kidney - metabolism ; Kinins - blood ; Kinins - metabolism ; Kinins - urine ; Rabbits ; Renal Circulation - drug effects</subject><ispartof>Journal of cardiovascular pharmacology, 1989-01, Vol.13 Suppl 6, p.S39-S42</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-ab833067d2f2a04bbd7e5f7860a440dc18a593d65b88479ddca364108a7ec243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198905006-00012$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,778,782,4597,27907,27908,65214</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2473347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seino, Masahide</creatorcontrib><creatorcontrib>Abe, Keishi</creatorcontrib><creatorcontrib>Nushiro, Noboru</creatorcontrib><creatorcontrib>Omata, Ken</creatorcontrib><creatorcontrib>Yoshinaga, Kaoru</creatorcontrib><title>Interaction of Atrial Natriuretic Peptide and Amiloride on Renal Hemodynamics Through Renal Kallikrein and Kinins in Anesthetized Rabbits</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>We investigated the interaction of atrial natriuretic peptide (ANP) and amiloride on renal function and the renal kallikrein-kinin system in anesthetized rabbits. The infusion of ANP alone (50 ng/kg/min) induced a natriuretic action with increments in renal blood flow (RBF) and creatinine clearance (Ccr). The infusion of ANP with amiloride (5 mg/kg + 0.04 mg/kg/min) produced a further increase in natriuresis despite the absence of an increase in RBF and Ccr induced by ANP alone. The urinary excretion of kallikrein and kinins was increased by the administration of ANP. However, the pretreatment with amiloride prevented the increase in the urinary excretion of kallikrein and kinins induced by ANP. These results suggest that the additive effect on sodium excretion might be attributable to changes in the tubular handling of sodium, although ANP did not modify the distal tubular function on sodium reabsorption. It is also suggested that the renal kallikrein-kinin system is not causally involved in the increased sodium excretion by ANP.</description><subject>Amiloride - pharmacology</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Kallikreins - blood</subject><subject>Kallikreins - metabolism</subject><subject>Kallikreins - urine</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kinins - blood</subject><subject>Kinins - metabolism</subject><subject>Kinins - urine</subject><subject>Rabbits</subject><subject>Renal Circulation - drug effects</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuFSEUhonR1Gv1EUxYuRuFgQFmedNo27Spprl7wsAZB8vAFWbS1DfwraW9t93J5uTw__-BnA8hTMlnSnr5hdTTMc4b2quedISIpt7Q9hXa0I6xhpOWvUYbQgVpWs7FW_SulF_VwTspTtBJyyVjXG7Q38u4QDZ28SniNOLtkr0J-MbUumZYvMU_YL94B9hEh7ezDyk_dtV-C7FaL2BO7iGa2duCd1NO68_pKF2ZEPxdBh-fwlc--lhw7bYRyjLV6X_A4VszDH4p79Gb0YQCH471FO2-fd2dXTTX388vz7bXjeWkaxszKMaIkK4dW0P4MDgJ3SiVIIZz4ixVpuuZE92gFJe9c9YwwSlRRoJtOTtFnw5j9zn9Xus39OyLhRBMhLQWLXuiFKOiGtXBaHMqJcOo99nPJj9oSvQjBP0MQb9A0E8QavTj8Y11mMG9BI9brzo_6Pcp1O2Xu7DeQ9YTmLBM-n9s2T8m85NI</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Seino, Masahide</creator><creator>Abe, Keishi</creator><creator>Nushiro, Noboru</creator><creator>Omata, Ken</creator><creator>Yoshinaga, Kaoru</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Interaction of Atrial Natriuretic Peptide and Amiloride on Renal Hemodynamics Through Renal Kallikrein and Kinins in Anesthetized Rabbits</title><author>Seino, Masahide ; Abe, Keishi ; Nushiro, Noboru ; Omata, Ken ; Yoshinaga, Kaoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-ab833067d2f2a04bbd7e5f7860a440dc18a593d65b88479ddca364108a7ec243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amiloride - pharmacology</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Blood Pressure - drug effects</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Kallikreins - blood</topic><topic>Kallikreins - metabolism</topic><topic>Kallikreins - urine</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kinins - blood</topic><topic>Kinins - metabolism</topic><topic>Kinins - urine</topic><topic>Rabbits</topic><topic>Renal Circulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seino, Masahide</creatorcontrib><creatorcontrib>Abe, Keishi</creatorcontrib><creatorcontrib>Nushiro, Noboru</creatorcontrib><creatorcontrib>Omata, Ken</creatorcontrib><creatorcontrib>Yoshinaga, Kaoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seino, Masahide</au><au>Abe, Keishi</au><au>Nushiro, Noboru</au><au>Omata, Ken</au><au>Yoshinaga, Kaoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of Atrial Natriuretic Peptide and Amiloride on Renal Hemodynamics Through Renal Kallikrein and Kinins in Anesthetized Rabbits</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>13 Suppl 6</volume><spage>S39</spage><epage>S42</epage><pages>S39-S42</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>We investigated the interaction of atrial natriuretic peptide (ANP) and amiloride on renal function and the renal kallikrein-kinin system in anesthetized rabbits. The infusion of ANP alone (50 ng/kg/min) induced a natriuretic action with increments in renal blood flow (RBF) and creatinine clearance (Ccr). The infusion of ANP with amiloride (5 mg/kg + 0.04 mg/kg/min) produced a further increase in natriuresis despite the absence of an increase in RBF and Ccr induced by ANP alone. The urinary excretion of kallikrein and kinins was increased by the administration of ANP. However, the pretreatment with amiloride prevented the increase in the urinary excretion of kallikrein and kinins induced by ANP. These results suggest that the additive effect on sodium excretion might be attributable to changes in the tubular handling of sodium, although ANP did not modify the distal tubular function on sodium reabsorption. It is also suggested that the renal kallikrein-kinin system is not causally involved in the increased sodium excretion by ANP.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2473347</pmid><doi>10.1097/00005344-198905006-00012</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cardiovascular pharmacology, 1989-01, Vol.13 Suppl 6, p.S39-S42 |
| issn | 0160-2446 1533-4023 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Amiloride - pharmacology Anesthesia Animals Atrial Natriuretic Factor - pharmacology Blood Pressure - drug effects Creatinine - blood Female Kallikreins - blood Kallikreins - metabolism Kallikreins - urine Kidney - drug effects Kidney - metabolism Kinins - blood Kinins - metabolism Kinins - urine Rabbits Renal Circulation - drug effects |
| title | Interaction of Atrial Natriuretic Peptide and Amiloride on Renal Hemodynamics Through Renal Kallikrein and Kinins in Anesthetized Rabbits |
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