Molecular evidence for an ancient duplication of the entire yeast genome
Gene duplication is an important source of evolutionary novelty. Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to...
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| Veröffentlicht in: | Nature (London) 1997-06, Vol.387 (6634), p.708-713 |
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| creator | Wolfe, K.H Shields, D.C |
| description | Gene duplication is an important source of evolutionary novelty. Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces. Only a small fraction of the genes were subsequently retained in duplicate (most were deleted), and gene order was rearranged by many reciprocal translocations between chromosomes. Protein pairs derived from this duplication event make up 13% of all yeast proteins, and include pairs of transcription factors, protein kinases, myosins, cyclins and pheromones. Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces. |
| doi_str_mv | 10.1038/42711 |
| format | Article |
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Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces. Only a small fraction of the genes were subsequently retained in duplicate (most were deleted), and gene order was rearranged by many reciprocal translocations between chromosomes. Protein pairs derived from this duplication event make up 13% of all yeast proteins, and include pairs of transcription factors, protein kinases, myosins, cyclins and pheromones. Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/42711</identifier><identifier>PMID: 9192896</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Bacteria ; Biological and medical sciences ; Biological evolution ; Chromosomes ; Chromosomes, Fungal ; Evolution ; Evolution, Molecular ; Fermentation ; Fundamental and applied biological sciences. Psychology ; gene dosage ; Genes ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Fungal ; genomics ; Hypotheses ; Kluyveromyces - genetics ; Models, Genetic ; Multigene Family ; Phylogeny ; Ploidies ; polyploidy ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - classification ; Saccharomyces cerevisiae - genetics ; Yeasts</subject><ispartof>Nature (London), 1997-06, Vol.387 (6634), p.708-713</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces. Only a small fraction of the genes were subsequently retained in duplicate (most were deleted), and gene order was rearranged by many reciprocal translocations between chromosomes. Protein pairs derived from this duplication event make up 13% of all yeast proteins, and include pairs of transcription factors, protein kinases, myosins, cyclins and pheromones. Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces.</description><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biological evolution</subject><subject>Chromosomes</subject><subject>Chromosomes, Fungal</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene dosage</subject><subject>Genes</subject><subject>Genetics of eukaryotes. 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Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces. Only a small fraction of the genes were subsequently retained in duplicate (most were deleted), and gene order was rearranged by many reciprocal translocations between chromosomes. Protein pairs derived from this duplication event make up 13% of all yeast proteins, and include pairs of transcription factors, protein kinases, myosins, cyclins and pheromones. Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>9192896</pmid><doi>10.1038/42711</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature (London), 1997-06, Vol.387 (6634), p.708-713 |
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| subjects | Bacteria Biological and medical sciences Biological evolution Chromosomes Chromosomes, Fungal Evolution Evolution, Molecular Fermentation Fundamental and applied biological sciences. Psychology gene dosage Genes Genetics of eukaryotes. Biological and molecular evolution Genome, Fungal genomics Hypotheses Kluyveromyces - genetics Models, Genetic Multigene Family Phylogeny Ploidies polyploidy Saccharomyces cerevisiae Saccharomyces cerevisiae - classification Saccharomyces cerevisiae - genetics Yeasts |
| title | Molecular evidence for an ancient duplication of the entire yeast genome |
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