Chromosome studies in thyroid neoplasia
Cytogenetic studies in thyroid neoplasia were performed by G‐banding of chromosome preparations obtained from the in vitro cultures of nine adenomas, one follicular carcinoma, five papillary carcinomas, and two medullary carcinomas. Complex structural chromosome aberrations were found in one adenoma...
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| Veröffentlicht in: | Cancer 1989-08, Vol.64 (3), p.680-685 |
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| container_title | Cancer |
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| creator | Bondeson, Lennart Bengtsson, Allan Bondeson, Anne‐Greth Dahlenfors, Rigmor Grimelius, Lars Wedell, Barbro Mark, Joachim |
| description | Cytogenetic studies in thyroid neoplasia were performed by G‐banding of chromosome preparations obtained from the in vitro cultures of nine adenomas, one follicular carcinoma, five papillary carcinomas, and two medullary carcinomas. Complex structural chromosome aberrations were found in one adenoma. Two more adenomas, both composed of Hürthle cells, showed multiple numerical chromosome deviations with trisomy 4 and tetrasomy 7 in common. Six metastasizing carcinomas were characterized by normal stemlines, which indicates that malignancy in thyroid neoplasia cannot be excluded by cytogenetic techniques used currently. Comparisons between cytogenetic findings and cytophotometric DNA measurements in the material studied illustrate that euploid tumors represent a heterogenous group including cases with various gross structural chromosome aberrations of yet unknown clinical significance. Further studies of additional material with long‐term follow‐up are called for by our findings of structural and numerical chromosome aberrations in follicular neoplasms that are benign according to histologic criteria. |
| doi_str_mv | 10.1002/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO;2-I |
| format | Article |
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Complex structural chromosome aberrations were found in one adenoma. Two more adenomas, both composed of Hürthle cells, showed multiple numerical chromosome deviations with trisomy 4 and tetrasomy 7 in common. Six metastasizing carcinomas were characterized by normal stemlines, which indicates that malignancy in thyroid neoplasia cannot be excluded by cytogenetic techniques used currently. Comparisons between cytogenetic findings and cytophotometric DNA measurements in the material studied illustrate that euploid tumors represent a heterogenous group including cases with various gross structural chromosome aberrations of yet unknown clinical significance. Further studies of additional material with long‐term follow‐up are called for by our findings of structural and numerical chromosome aberrations in follicular neoplasms that are benign according to histologic criteria.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO;2-I</identifier><identifier>PMID: 2743263</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenoma - genetics ; Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Biological and medical sciences ; Carcinoma - genetics ; Carcinoma - secondary ; Chromosome Aberrations ; Chromosome Banding ; Chromosome Disorders ; DNA, Neoplasm - analysis ; Endocrinopathies ; Female ; Humans ; Karyotyping ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Thyroid Neoplasms - genetics ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Cancer, 1989-08, Vol.64 (3), p.680-685</ispartof><rights>Copyright © 1989 American Cancer Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4969-8e029e5d91013a8a7de4d2a8e5fd4e5578bd69158b12808813f30ae5cb9b31113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19675511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2743263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondeson, Lennart</creatorcontrib><creatorcontrib>Bengtsson, Allan</creatorcontrib><creatorcontrib>Bondeson, Anne‐Greth</creatorcontrib><creatorcontrib>Dahlenfors, Rigmor</creatorcontrib><creatorcontrib>Grimelius, Lars</creatorcontrib><creatorcontrib>Wedell, Barbro</creatorcontrib><creatorcontrib>Mark, Joachim</creatorcontrib><title>Chromosome studies in thyroid neoplasia</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Cytogenetic studies in thyroid neoplasia were performed by G‐banding of chromosome preparations obtained from the in vitro cultures of nine adenomas, one follicular carcinoma, five papillary carcinomas, and two medullary carcinomas. Complex structural chromosome aberrations were found in one adenoma. Two more adenomas, both composed of Hürthle cells, showed multiple numerical chromosome deviations with trisomy 4 and tetrasomy 7 in common. Six metastasizing carcinomas were characterized by normal stemlines, which indicates that malignancy in thyroid neoplasia cannot be excluded by cytogenetic techniques used currently. Comparisons between cytogenetic findings and cytophotometric DNA measurements in the material studied illustrate that euploid tumors represent a heterogenous group including cases with various gross structural chromosome aberrations of yet unknown clinical significance. Further studies of additional material with long‐term follow‐up are called for by our findings of structural and numerical chromosome aberrations in follicular neoplasms that are benign according to histologic criteria.</description><subject>Adenoma - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - secondary</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosome Disorders</subject><subject>DNA, Neoplasm - analysis</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAYhcXo6LJsP2Hgm3bbhbNXn5ayMsi8L0NZYKwwdvMi2zLxsOPUihn591UWN6W7KPRKiHN0ePQQ8pHCjAKwdxRMEgMV7A012oAG-laJOb9QGubzRfYpTr-nP5hmoARwaj7wGczS5XsWZ0_I5Pj4hEwAQMdS8F_PyHPv_4RrwiQ_JacsEZwpPiGv01XftZ3vWhf57VDWzkf1Otqudn1Xl9HadZvG-tq-IE8r23j3cjyn5OrL55_pt_hy-TVLF5dxIYwysXbAjJOloUC51TYpnSiZ1U5WpXBSJjovlaFS55Rp0JryioN1sshNzimlfErOD7ubvrsenN9iW_vCNY0NKIPHJOgIMyoUfx-KRd9537sKN33d2n6HFHBvEfcicC8Cby2iEsgxWEQMFvG-xZAApktkmIXxVyPFkLeuPE6P2kJ-NubWF7apersuan9HYFQi5b_fuEPvb9243aMIHwT8L-E3T5iaOw</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Bondeson, Lennart</creator><creator>Bengtsson, Allan</creator><creator>Bondeson, Anne‐Greth</creator><creator>Dahlenfors, Rigmor</creator><creator>Grimelius, Lars</creator><creator>Wedell, Barbro</creator><creator>Mark, Joachim</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Chromosome studies in thyroid neoplasia</title><author>Bondeson, Lennart ; Bengtsson, Allan ; Bondeson, Anne‐Greth ; Dahlenfors, Rigmor ; Grimelius, Lars ; Wedell, Barbro ; Mark, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4969-8e029e5d91013a8a7de4d2a8e5fd4e5578bd69158b12808813f30ae5cb9b31113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenoma - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - secondary</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosome Disorders</topic><topic>DNA, Neoplasm - analysis</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondeson, Lennart</creatorcontrib><creatorcontrib>Bengtsson, Allan</creatorcontrib><creatorcontrib>Bondeson, Anne‐Greth</creatorcontrib><creatorcontrib>Dahlenfors, Rigmor</creatorcontrib><creatorcontrib>Grimelius, Lars</creatorcontrib><creatorcontrib>Wedell, Barbro</creatorcontrib><creatorcontrib>Mark, Joachim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondeson, Lennart</au><au>Bengtsson, Allan</au><au>Bondeson, Anne‐Greth</au><au>Dahlenfors, Rigmor</au><au>Grimelius, Lars</au><au>Wedell, Barbro</au><au>Mark, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome studies in thyroid neoplasia</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>64</volume><issue>3</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Cytogenetic studies in thyroid neoplasia were performed by G‐banding of chromosome preparations obtained from the in vitro cultures of nine adenomas, one follicular carcinoma, five papillary carcinomas, and two medullary carcinomas. Complex structural chromosome aberrations were found in one adenoma. Two more adenomas, both composed of Hürthle cells, showed multiple numerical chromosome deviations with trisomy 4 and tetrasomy 7 in common. Six metastasizing carcinomas were characterized by normal stemlines, which indicates that malignancy in thyroid neoplasia cannot be excluded by cytogenetic techniques used currently. Comparisons between cytogenetic findings and cytophotometric DNA measurements in the material studied illustrate that euploid tumors represent a heterogenous group including cases with various gross structural chromosome aberrations of yet unknown clinical significance. Further studies of additional material with long‐term follow‐up are called for by our findings of structural and numerical chromosome aberrations in follicular neoplasms that are benign according to histologic criteria.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2743263</pmid><doi>10.1002/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO;2-I</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma - genetics Adult Aged Aged, 80 and over Aneuploidy Biological and medical sciences Carcinoma - genetics Carcinoma - secondary Chromosome Aberrations Chromosome Banding Chromosome Disorders DNA, Neoplasm - analysis Endocrinopathies Female Humans Karyotyping Male Malignant tumors Medical sciences Middle Aged Thyroid Neoplasms - genetics Thyroid. Thyroid axis (diseases) |
| title | Chromosome studies in thyroid neoplasia |
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