Experimental milk formulae with reduced protein content and desialylated milk proteins: influence on the faecal flora and the growth of term newborn infants
We have assessed the growth, tolerance and the faecal flora composition in healthy infants on different feeding regimens. Four groups of infants were fed exclusively on mother's milk, a standard formula and two experimental formulae. The first experimental formula consisted of a milk with a red...
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| Veröffentlicht in: | Acta Paediatrica 1997-06, Vol.86 (6), p.557-563 |
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| creator | Chierici, R Sawatzki, G Thurl, S Tovar, K Vigi, V |
| description | We have assessed the growth, tolerance and the faecal flora composition in healthy infants on different feeding regimens. Four groups of infants were fed exclusively on mother's milk, a standard formula and two experimental formulae. The first experimental formula consisted of a milk with a reduced protein content (1.2 g/100 ml), the second in a formula with the same protein content and with milk proteins desialylated by mild acid hydrolysis. The aim of the study was to test whether lowering the protein content and/or modifying the proteins by desialylation would favour the development of a bifidus flora. A bifidus flora was detected in 60% of breastfed infants at 1 month of life. All formulae employed during the study failed to induce a prevalence of colonization with bifidobacteria at 1 month of age. The two experimental milk formulae were well tolerated, but the infant growth rate was slightly lower as compared to the breastfed infants and the infants fed the standard formula. The presence in milk formulae of pre‐digested and desialylated proteins can offer some advantages in term of digestibility and mimic a physiological intestinal mechanism of the infant. |
| doi_str_mv | 10.1111/j.1651-2227.1997.tb08934.x |
| format | Article |
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Four groups of infants were fed exclusively on mother's milk, a standard formula and two experimental formulae. The first experimental formula consisted of a milk with a reduced protein content (1.2 g/100 ml), the second in a formula with the same protein content and with milk proteins desialylated by mild acid hydrolysis. The aim of the study was to test whether lowering the protein content and/or modifying the proteins by desialylation would favour the development of a bifidus flora. A bifidus flora was detected in 60% of breastfed infants at 1 month of life. All formulae employed during the study failed to induce a prevalence of colonization with bifidobacteria at 1 month of age. The two experimental milk formulae were well tolerated, but the infant growth rate was slightly lower as compared to the breastfed infants and the infants fed the standard formula. The presence in milk formulae of pre‐digested and desialylated proteins can offer some advantages in term of digestibility and mimic a physiological intestinal mechanism of the infant.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.1997.tb08934.x</identifier><identifier>PMID: 9202787</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Bifidobacteria ; Biological and medical sciences ; Breast Feeding ; Enterococcus - isolation & purification ; faecal flora ; Feces - chemistry ; Food, Formulated ; Fundamental and applied biological sciences. Psychology ; Gram-Positive Bacteria - isolation & purification ; Humans ; Infant, Newborn - growth & development ; Intestine. Mesentery ; milk formula ; Milk Proteins - chemistry ; N-Acetylneuraminic Acid - analysis ; newborn ; protein ; sialic acid ; Vertebrates: digestive system</subject><ispartof>Acta Paediatrica, 1997-06, Vol.86 (6), p.557-563</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4367-5331b9eb906efaf9bc71bcb84a178694581c1852cd98cb9b144974579d4327513</citedby><cites>FETCH-LOGICAL-c4367-5331b9eb906efaf9bc71bcb84a178694581c1852cd98cb9b144974579d4327513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.1997.tb08934.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.1997.tb08934.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2705392$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9202787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chierici, R</creatorcontrib><creatorcontrib>Sawatzki, G</creatorcontrib><creatorcontrib>Thurl, S</creatorcontrib><creatorcontrib>Tovar, K</creatorcontrib><creatorcontrib>Vigi, V</creatorcontrib><title>Experimental milk formulae with reduced protein content and desialylated milk proteins: influence on the faecal flora and the growth of term newborn infants</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>We have assessed the growth, tolerance and the faecal flora composition in healthy infants on different feeding regimens. Four groups of infants were fed exclusively on mother's milk, a standard formula and two experimental formulae. The first experimental formula consisted of a milk with a reduced protein content (1.2 g/100 ml), the second in a formula with the same protein content and with milk proteins desialylated by mild acid hydrolysis. The aim of the study was to test whether lowering the protein content and/or modifying the proteins by desialylation would favour the development of a bifidus flora. A bifidus flora was detected in 60% of breastfed infants at 1 month of life. All formulae employed during the study failed to induce a prevalence of colonization with bifidobacteria at 1 month of age. The two experimental milk formulae were well tolerated, but the infant growth rate was slightly lower as compared to the breastfed infants and the infants fed the standard formula. The presence in milk formulae of pre‐digested and desialylated proteins can offer some advantages in term of digestibility and mimic a physiological intestinal mechanism of the infant.</description><subject>Bifidobacteria</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>Enterococcus - isolation & purification</subject><subject>faecal flora</subject><subject>Feces - chemistry</subject><subject>Food, Formulated</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Positive Bacteria - isolation & purification</subject><subject>Humans</subject><subject>Infant, Newborn - growth & development</subject><subject>Intestine. Mesentery</subject><subject>milk formula</subject><subject>Milk Proteins - chemistry</subject><subject>N-Acetylneuraminic Acid - analysis</subject><subject>newborn</subject><subject>protein</subject><subject>sialic acid</subject><subject>Vertebrates: digestive system</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc2O0zAUhSMEGsrAIyBZCLFL8U8cx7NAqqr5Q8PAAsTScpwbJh3HKbajtu_Cw44zjbrHG0u-37nHOifLPhC8JOl83ixJyUlOKRVLIqVYxhpXkhXL_YtscRq9zBa4wiznlLPX2ZsQNhhTJovyLDuTFFNRiUX273K_Bd_14KK2qO_sI2oH349WA9p18QF5aEYDDdr6IULnkBlcTDDSrkENhE7bg9UxAc_amQoXqHOtHcEZQIND8QFQq8Eki9YOXj-rp8c_ftglk6FFEXyPHOzqwbtJrF0Mb7NXrbYB3s33efbr6vLn-ia_-359u17d5aZgpcg5Y6SWUEtcQqtbWRtBalNXhSaiKmXBK2JIxalpZGVqWZOikKLgQjYFo4ITdp59Ou5N3_87Qoiq74IBa7WDYQxKSFwVnE7gxRE0fgjBQ6u2KTvtD4pgNVWjNmrKX035q6kaNVej9kn8fnYZ6x6ak3TuIs0_znMdUlKt18504YRRgTmTNGFfjtius3D4jw-o1Y8V55NPflzQhQj70wLtH1UpmODq9_21urnHa3r1Dauv7An9Y70T</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>Chierici, R</creator><creator>Sawatzki, G</creator><creator>Thurl, S</creator><creator>Tovar, K</creator><creator>Vigi, V</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199706</creationdate><title>Experimental milk formulae with reduced protein content and desialylated milk proteins: influence on the faecal flora and the growth of term newborn infants</title><author>Chierici, R ; Sawatzki, G ; Thurl, S ; Tovar, K ; Vigi, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4367-5331b9eb906efaf9bc71bcb84a178694581c1852cd98cb9b144974579d4327513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Bifidobacteria</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding</topic><topic>Enterococcus - isolation & purification</topic><topic>faecal flora</topic><topic>Feces - chemistry</topic><topic>Food, Formulated</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Positive Bacteria - isolation & purification</topic><topic>Humans</topic><topic>Infant, Newborn - growth & development</topic><topic>Intestine. Mesentery</topic><topic>milk formula</topic><topic>Milk Proteins - chemistry</topic><topic>N-Acetylneuraminic Acid - analysis</topic><topic>newborn</topic><topic>protein</topic><topic>sialic acid</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chierici, R</creatorcontrib><creatorcontrib>Sawatzki, G</creatorcontrib><creatorcontrib>Thurl, S</creatorcontrib><creatorcontrib>Tovar, K</creatorcontrib><creatorcontrib>Vigi, V</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chierici, R</au><au>Sawatzki, G</au><au>Thurl, S</au><au>Tovar, K</au><au>Vigi, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental milk formulae with reduced protein content and desialylated milk proteins: influence on the faecal flora and the growth of term newborn infants</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>1997-06</date><risdate>1997</risdate><volume>86</volume><issue>6</issue><spage>557</spage><epage>563</epage><pages>557-563</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>We have assessed the growth, tolerance and the faecal flora composition in healthy infants on different feeding regimens. Four groups of infants were fed exclusively on mother's milk, a standard formula and two experimental formulae. The first experimental formula consisted of a milk with a reduced protein content (1.2 g/100 ml), the second in a formula with the same protein content and with milk proteins desialylated by mild acid hydrolysis. The aim of the study was to test whether lowering the protein content and/or modifying the proteins by desialylation would favour the development of a bifidus flora. A bifidus flora was detected in 60% of breastfed infants at 1 month of life. All formulae employed during the study failed to induce a prevalence of colonization with bifidobacteria at 1 month of age. The two experimental milk formulae were well tolerated, but the infant growth rate was slightly lower as compared to the breastfed infants and the infants fed the standard formula. The presence in milk formulae of pre‐digested and desialylated proteins can offer some advantages in term of digestibility and mimic a physiological intestinal mechanism of the infant.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9202787</pmid><doi>10.1111/j.1651-2227.1997.tb08934.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Bifidobacteria Biological and medical sciences Breast Feeding Enterococcus - isolation & purification faecal flora Feces - chemistry Food, Formulated Fundamental and applied biological sciences. Psychology Gram-Positive Bacteria - isolation & purification Humans Infant, Newborn - growth & development Intestine. Mesentery milk formula Milk Proteins - chemistry N-Acetylneuraminic Acid - analysis newborn protein sialic acid Vertebrates: digestive system |
| title | Experimental milk formulae with reduced protein content and desialylated milk proteins: influence on the faecal flora and the growth of term newborn infants |
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