Molecular mechanisms regulating the myofilament response to Ca2+: implications of mutations causal for familial hypertrophic cardiomyopathy

In this chapter we consider a current perception of the molecular mechanisms controlling myofilament activation with emphasis on alterations that may occur in familial hypertrophic cardiomyopathy (FHC). FHC is a sarcomeric disease (100) with an autosomal dominant pattern of heritability (27, 51). Th...

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Veröffentlicht in:	Basic research in cardiology 1997, Vol.92 Suppl 1 (S1), p.63-74
Hauptverfasser:	Palmiter, K A, Solaro, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - physiology Animals Calcium - physiology Cardiomyopathy, Hypertrophic - genetics Humans Mutation Myosins - genetics Myosins - physiology Tropomyosin - genetics Troponin - genetics Troponin T
Online-Zugang:	Volltext
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