Facilitation of feeding by nucleus accumbens amphetamine injections: Latency and speed measures
Food-deprived rats were offered food in small meal segments, and latency to initiate feeding and time to complete it were recorded for each segment. Bilateral microinjections of d-amphetamine into nucleus accumbens dramatically increased the mean speed with which meal segments were eaten, but had no...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-03, Vol.32 (3), p.769-772 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Wise, Roy A. Fotuhi, Majid Colle, Lois M. |
| description | Food-deprived rats were offered food in small meal segments, and latency to initiate feeding and time to complete it were recorded for each segment. Bilateral microinjections of
d-amphetamine into nucleus accumbens dramatically increased the mean speed with which meal segments were eaten, but had no reliable effect on mean latency to initiate eating of new segments;
l-amphetamine had similar but weaker effects. While mean eating speed was increased, this increase resulted from a decrease in the frequency of slow trials and not from an increase in the absolute speed of the fastest trials. These data suggest that amphetamine facilitates feeding by some other means than simple improvement of the motoric capacity of the animal, and they indicate that nucleus accumbens is an important site for amphetamine's established but not widely appreciated facilitory effects on feeding. |
| doi_str_mv | 10.1016/0091-3057(89)90031-2 |
| format | Article |
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d-amphetamine into nucleus accumbens dramatically increased the mean speed with which meal segments were eaten, but had no reliable effect on mean latency to initiate eating of new segments;
l-amphetamine had similar but weaker effects. While mean eating speed was increased, this increase resulted from a decrease in the frequency of slow trials and not from an increase in the absolute speed of the fastest trials. These data suggest that amphetamine facilitates feeding by some other means than simple improvement of the motoric capacity of the animal, and they indicate that nucleus accumbens is an important site for amphetamine's established but not widely appreciated facilitory effects on feeding.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(89)90031-2</identifier><identifier>PMID: 2740428</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amphetamine ; Amphetamines - pharmacology ; Animals ; Appetite ; Biological and medical sciences ; Feeding ; Feeding Behavior - drug effects ; Male ; Medical sciences ; Neuropharmacology ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Reaction Time - drug effects ; Reaction Time - physiology ; Septal Nuclei - physiology</subject><ispartof>Pharmacology, biochemistry and behavior, 1989-03, Vol.32 (3), p.769-772</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-51e9ea96bf016cb70198fe7873c5956cd2bc11c5e4344dceea3cfb9fb7c269d83</citedby><cites>FETCH-LOGICAL-c417t-51e9ea96bf016cb70198fe7873c5956cd2bc11c5e4344dceea3cfb9fb7c269d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(89)90031-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6852851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2740428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wise, Roy A.</creatorcontrib><creatorcontrib>Fotuhi, Majid</creatorcontrib><creatorcontrib>Colle, Lois M.</creatorcontrib><title>Facilitation of feeding by nucleus accumbens amphetamine injections: Latency and speed measures</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Food-deprived rats were offered food in small meal segments, and latency to initiate feeding and time to complete it were recorded for each segment. Bilateral microinjections of
d-amphetamine into nucleus accumbens dramatically increased the mean speed with which meal segments were eaten, but had no reliable effect on mean latency to initiate eating of new segments;
l-amphetamine had similar but weaker effects. While mean eating speed was increased, this increase resulted from a decrease in the frequency of slow trials and not from an increase in the absolute speed of the fastest trials. These data suggest that amphetamine facilitates feeding by some other means than simple improvement of the motoric capacity of the animal, and they indicate that nucleus accumbens is an important site for amphetamine's established but not widely appreciated facilitory effects on feeding.</description><subject>Amphetamine</subject><subject>Amphetamines - pharmacology</subject><subject>Animals</subject><subject>Appetite</subject><subject>Biological and medical sciences</subject><subject>Feeding</subject><subject>Feeding Behavior - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. 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Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. 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Bilateral microinjections of
d-amphetamine into nucleus accumbens dramatically increased the mean speed with which meal segments were eaten, but had no reliable effect on mean latency to initiate eating of new segments;
l-amphetamine had similar but weaker effects. While mean eating speed was increased, this increase resulted from a decrease in the frequency of slow trials and not from an increase in the absolute speed of the fastest trials. These data suggest that amphetamine facilitates feeding by some other means than simple improvement of the motoric capacity of the animal, and they indicate that nucleus accumbens is an important site for amphetamine's established but not widely appreciated facilitory effects on feeding.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2740428</pmid><doi>10.1016/0091-3057(89)90031-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1989-03, Vol.32 (3), p.769-772 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79083661 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amphetamine Amphetamines - pharmacology Animals Appetite Biological and medical sciences Feeding Feeding Behavior - drug effects Male Medical sciences Neuropharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Reaction Time - drug effects Reaction Time - physiology Septal Nuclei - physiology |
| title | Facilitation of feeding by nucleus accumbens amphetamine injections: Latency and speed measures |
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