Safety and Pharmacokinetics of Multiple Doses of Recombinant Human CuZn Superoxide Dismutase Administered Intratracheally to Premature Neonates With Respiratory Distress Syndrome

To examine the safety and pharmacokinetics of multiple intratracheal (IT) doses of recombinant human CuZn superoxide dismutase (rhSOD) in premature infants with respiratory distress syndrome who are at risk for developing bronchopulmonary dysplasia (BPD). Methods. Thirty-three infants (700 to 1300 g...

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Veröffentlicht in:	Pediatrics (Evanston) 1997-07, Vol.100 (1), p.24-30
Hauptverfasser:	Davis, Jonathan M, Rosenfeld, Warren N, Richter, Susan E, Parad, Richard, Gewolb, Ira H, Spitzer, Alan R, Carlo, Waldemar A, Couser, Robert J, Price, Anita, Flaster, Edith, Kassem, Nadim, Edwards, Lionel, Tierney, Joan, Horowitz, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Antibodies - analysis Babies Biological and medical sciences Blotting, Western Bronchopulmonary Dysplasia - prevention & control Care and treatment Enzyme-Linked Immunosorbent Assay Health aspects Humans Infant, Newborn Infants (Premature) Intubation, Intratracheal Lungs Medical sciences Pediatrics Pharmacology. Drug treatments Placebos Premature infants Recombinant Proteins Respiratory diseases Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - blood Respiratory Distress Syndrome, Newborn - diagnosis Respiratory Distress Syndrome, Newborn - drug therapy Respiratory system Safety Superoxide dismutase Superoxide Dismutase - administration & dosage Superoxide Dismutase - immunology Superoxide Dismutase - pharmacokinetics Time Factors
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