Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B

Here we describe the characterization of a novel human CC chemokine, tentatively named monocyte chemotactic protein (MCP-4). This chemokine was detected by random sequencing of expressed sequence tags in cDNA libraries. The full-length cDNA revealed an open reading frame for a 98-amino acid residue...

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Veröffentlicht in:	The Journal of biological chemistry 1997-06, Vol.272 (26), p.16404-16413
Hauptverfasser:	Berkhout, Theo A., Sarau, Henry M., Moores, Kitty, White, John R, Elshourbagy, Nabil, Appelbaum, Edward, Brawner, Theresa J., Reape, Mary, Makwana, Jayneeta, Foley, James J., Schmidt, Dulcie B, Imburgia, Christine, McNulty, Dean, Matthews, Jane, O'Donnell, Kevin, O'Shannessy, Daniel, Scott, Miller, Groot, Pieter H.E., Macphee, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arteriosclerosis - metabolism Binding, Competitive Blotting, Western Calcium - metabolism CHO Cells Cloning, Molecular Cricetinae Humans Molecular Sequence Data Monocyte Chemoattractant Proteins - analysis Monocyte Chemoattractant Proteins - metabolism Monocyte Chemoattractant Proteins - pharmacology Receptors, CCR2 Receptors, Chemokine Receptors, Cytokine - metabolism Recombinant Proteins - biosynthesis RNA, Messenger - analysis
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