Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects
To establish reference ranges for use in clinical and epidemiological studies, we determined concentrations of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene in 450 Spanish control subjects and 123 Spanish patients with insulin-dependen...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 1997-06, Vol.43 (6), p.1066-1071 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Olmedilla, Begona Granado, Fernando Gil-Martinez, Enrique Blanco, Inmaculada Rojas-Hidalgo, Enrique |
| description | To establish reference ranges for use in clinical and epidemiological studies, we determined concentrations of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene in 450 Spanish control subjects and 123 Spanish patients with insulin-dependent diabetes mellitus (IDDM). Results were grouped according to sex, and samples were collected throughout the year. Concentrations of retinol were significantly lower and beta-carotene and alpha-carotene were higher in women than in men, both in controls and IDDM subjects, whereas beta-cryptoxanthin concentrations were higher only in control women. Conditional logistic regression analysis showed that retinol, beta-carotene, and lycopene were the variables associated with diabetes. In comparison with other populations, our controls showed, in general, ordinary concentrations of retinol, comparatively low beta-carotene and high beta-cryptoxanthin concentrations, and a relatively high alpha-tocopherol/ cholesterol ratio. |
| doi_str_mv | 10.1093/clinchem/43.6.1066 |
| format | Article |
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Results were grouped according to sex, and samples were collected throughout the year. Concentrations of retinol were significantly lower and beta-carotene and alpha-carotene were higher in women than in men, both in controls and IDDM subjects, whereas beta-cryptoxanthin concentrations were higher only in control women. Conditional logistic regression analysis showed that retinol, beta-carotene, and lycopene were the variables associated with diabetes. In comparison with other populations, our controls showed, in general, ordinary concentrations of retinol, comparatively low beta-carotene and high beta-cryptoxanthin concentrations, and a relatively high alpha-tocopherol/ cholesterol ratio.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1093/clinchem/43.6.1066</identifier><identifier>PMID: 9191562</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Adolescent ; Adult ; Aged ; Antioxidants - metabolism ; beta Carotene - analogs & derivatives ; beta Carotene - blood ; Biological and medical sciences ; Carotenoids - blood ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Humans ; Lutein - blood ; Male ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Middle Aged ; Reference Values ; Regression Analysis ; Sex Factors ; Spain ; Vitamin A - blood ; Vitamin E - blood ; Xanthophylls ; Zeaxanthins</subject><ispartof>Clinical chemistry (Baltimore, Md.), 1997-06, Vol.43 (6), p.1066-1071</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-d76faf76f70d2a7dafcfc12447c337559890699cdfe04ae4f9417530c0a250723</citedby><cites>FETCH-LOGICAL-c468t-d76faf76f70d2a7dafcfc12447c337559890699cdfe04ae4f9417530c0a250723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2692938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9191562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olmedilla, Begona</creatorcontrib><creatorcontrib>Granado, Fernando</creatorcontrib><creatorcontrib>Gil-Martinez, Enrique</creatorcontrib><creatorcontrib>Blanco, Inmaculada</creatorcontrib><creatorcontrib>Rojas-Hidalgo, Enrique</creatorcontrib><title>Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>To establish reference ranges for use in clinical and epidemiological studies, we determined concentrations of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene in 450 Spanish control subjects and 123 Spanish patients with insulin-dependent diabetes mellitus (IDDM). Results were grouped according to sex, and samples were collected throughout the year. Concentrations of retinol were significantly lower and beta-carotene and alpha-carotene were higher in women than in men, both in controls and IDDM subjects, whereas beta-cryptoxanthin concentrations were higher only in control women. Conditional logistic regression analysis showed that retinol, beta-carotene, and lycopene were the variables associated with diabetes. In comparison with other populations, our controls showed, in general, ordinary concentrations of retinol, comparatively low beta-carotene and high beta-cryptoxanthin concentrations, and a relatively high alpha-tocopherol/ cholesterol ratio.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants - metabolism</subject><subject>beta Carotene - analogs & derivatives</subject><subject>beta Carotene - blood</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Lutein - blood</subject><subject>Male</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>Spain</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><subject>Xanthophylls</subject><subject>Zeaxanthins</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1vFSEQhomxqcfqHzAx4cJ45bawy8JyaRq_kiYmrV4TDgwuDQsr7PbEW395WXtsb4CZeead4UXoDSXnlMjuwgQfzQjTBevOeU1x_gztaN-RZug5fY52hBDZSMrEC_SylNsaMjHwU3QqqaQ9b3fo7zU4yBAN4DsdVijYpYwzLD6m8AEvyaR5hLy9dbR40j5io3NaICZvC65hgbxOODlsUlwq-Q_0sax1u8bCDNFCXLD1el9lDb6ZdfRlxGXd34JZyit04nQo8Pp4n6Gfnz_9uPzaXH3_8u3y41VjGB-WxgrutKuHILbVwmpnnKEtY8J0neh7OUjCpTTWAWEamJOMiuqFIbrtiWi7M_T-QXfO6Xf96aImXwyEoCOktSghydByuYHtA2hyKiWDU3P2k85_FCVqM179N16xTnG1GV-b3h7V1_0E9rHl6HStvzvWdTE6uKyj8eUR2wbLbnhacvS_xoPPoMqkQ6iiVB0Oh6d599oGnV0</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Olmedilla, Begona</creator><creator>Granado, Fernando</creator><creator>Gil-Martinez, Enrique</creator><creator>Blanco, Inmaculada</creator><creator>Rojas-Hidalgo, Enrique</creator><general>Am Assoc Clin Chem</general><general>American Association for Clinical Chemistry</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects</title><author>Olmedilla, Begona ; Granado, Fernando ; Gil-Martinez, Enrique ; Blanco, Inmaculada ; Rojas-Hidalgo, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-d76faf76f70d2a7dafcfc12447c337559890699cdfe04ae4f9417530c0a250723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants - metabolism</topic><topic>beta Carotene - analogs & derivatives</topic><topic>beta Carotene - blood</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Lutein - blood</topic><topic>Male</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><topic>Spain</topic><topic>Vitamin A - blood</topic><topic>Vitamin E - blood</topic><topic>Xanthophylls</topic><topic>Zeaxanthins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olmedilla, Begona</creatorcontrib><creatorcontrib>Granado, Fernando</creatorcontrib><creatorcontrib>Gil-Martinez, Enrique</creatorcontrib><creatorcontrib>Blanco, Inmaculada</creatorcontrib><creatorcontrib>Rojas-Hidalgo, Enrique</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olmedilla, Begona</au><au>Granado, Fernando</au><au>Gil-Martinez, Enrique</au><au>Blanco, Inmaculada</au><au>Rojas-Hidalgo, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>43</volume><issue>6</issue><spage>1066</spage><epage>1071</epage><pages>1066-1071</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>To establish reference ranges for use in clinical and epidemiological studies, we determined concentrations of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene in 450 Spanish control subjects and 123 Spanish patients with insulin-dependent diabetes mellitus (IDDM). Results were grouped according to sex, and samples were collected throughout the year. Concentrations of retinol were significantly lower and beta-carotene and alpha-carotene were higher in women than in men, both in controls and IDDM subjects, whereas beta-cryptoxanthin concentrations were higher only in control women. Conditional logistic regression analysis showed that retinol, beta-carotene, and lycopene were the variables associated with diabetes. In comparison with other populations, our controls showed, in general, ordinary concentrations of retinol, comparatively low beta-carotene and high beta-cryptoxanthin concentrations, and a relatively high alpha-tocopherol/ cholesterol ratio.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>9191562</pmid><doi>10.1093/clinchem/43.6.1066</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical chemistry (Baltimore, Md.), 1997-06, Vol.43 (6), p.1066-1071 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Adult Aged Antioxidants - metabolism beta Carotene - analogs & derivatives beta Carotene - blood Biological and medical sciences Carotenoids - blood Child Child, Preschool Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Lutein - blood Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Middle Aged Reference Values Regression Analysis Sex Factors Spain Vitamin A - blood Vitamin E - blood Xanthophylls Zeaxanthins |
| title | Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects |
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