The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type 1 IGF receptor gene

We previously reported that a 16-kDa proteolytic fragment of IGF Binding Protein-3 (IGFBP-3), which is devoid of affinity for IGFs, inhibits the mitogenic effects of IGF-I on chick embryo fibroblasts. Here, we set out to determine if the fragment had biological effects on fibroblasts from mouse embr...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-07, Vol.138 (7), p.3069-3072
Hauptverfasser:	Zadeh, S M, Binoux, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Fibroblast Growth Factor 2 - pharmacology Fibroblast Growth Factors - antagonists & inhibitors Fibroblasts - drug effects Humans Insulin-Like Growth Factor Binding Protein 3 - pharmacology Mice Molecular Weight Peptide Fragments - pharmacology Receptor, IGF Type 1 - genetics Thymidine - metabolism
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