Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity: Structure-Activity Relationships of Big Endothelin-1

SUMMARYThe vasoconstrictor activities of porcine big endothelin-1 (big ET-1), a 39-residue intermediate predicted from cDNA sequence analysis, and of its shorter derivative, big ET-1 [1–25], were characterized in vitro by measuring the contraction of porcine coronary artery strips. Synthetic big ET-...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1989, Vol.13 Suppl 5, p.S5-7
Hauptverfasser:	Kimura, Sadao, Kasuya, Yoshitoshi, Sawamura, Tatsuya, Shinmi, Osamu, Sugita, Yoshiki, Yanagisawa, Masashi, Goto, Katsutoshi, Masaki, Tomoh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endothelins In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Peptides - analysis Peptides - pharmacology Structure-Activity Relationship Swine Vasoconstriction - drug effects
Online-Zugang:	Volltext
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