Clonidine and Morphine Increase Atrial Natriuretic Peptide Secretion in Anesthetized Rats
Abstract In order to determine whether the activity of central α 2-adrenergic and opioid receptors influence plasma atrial natriuretic peptide (ANP) levels, clonidine and morphine were infused into the lateral cerebral ventricle for 45 min in anesthetized Sprague-Dawley rats. The central administrat...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1989-07, Vol.191 (3), p.299-303 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 191 |
| creator | Chen, Min Lee, Jongeun Huang, Bing S. Grekin, Roger J. Malvin, Richard L. |
| description | Abstract
In order to determine whether the activity of central α
2-adrenergic and opioid receptors influence plasma atrial natriuretic peptide (ANP) levels, clonidine and morphine were infused into the lateral cerebral ventricle for 45 min in anesthetized Sprague-Dawley rats. The central administration of a low dose of clonidine (10 ng/min) caused a significant increase in plasma ANP without changing arterial blood pressure or central venous pressure. Pretreatment with yohimbine (5 μg/min) completely blocked the effect of clonidine. Central infusion of morphine (100 ng/min) also elevated plasma ANP levels and naloxone (5 μg/min) blunted this effect. Intravenous infusion of the same dose of clonidine or morphine did not affect plasma ANP levels. Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 μg/min). These results suggest that central α
2-adrenergic and opioid receptors may be involved in ANP secretion. |
| doi_str_mv | 10.3181/00379727-191-42924 |
| format | Article |
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In order to determine whether the activity of central α
2-adrenergic and opioid receptors influence plasma atrial natriuretic peptide (ANP) levels, clonidine and morphine were infused into the lateral cerebral ventricle for 45 min in anesthetized Sprague-Dawley rats. The central administration of a low dose of clonidine (10 ng/min) caused a significant increase in plasma ANP without changing arterial blood pressure or central venous pressure. Pretreatment with yohimbine (5 μg/min) completely blocked the effect of clonidine. Central infusion of morphine (100 ng/min) also elevated plasma ANP levels and naloxone (5 μg/min) blunted this effect. Intravenous infusion of the same dose of clonidine or morphine did not affect plasma ANP levels. Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 μg/min). These results suggest that central α
2-adrenergic and opioid receptors may be involved in ANP secretion.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-191-42924</identifier><identifier>PMID: 2525782</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anesthesia ; Animals ; Atrial Natriuretic Factor - metabolism ; atrial natriuretic hormone ; Clonidine - administration & dosage ; Clonidine - pharmacology ; heart ; Injections, Intraventricular ; Male ; Morphine - administration & dosage ; Morphine - pharmacology ; opiates ; Rats ; Rats, Inbred Strains</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1989-07, Vol.191 (3), p.299-303</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-8c471964b808d7c27bd7374bb9e470b24c123944d059d4d4cad1a34ebc0c22043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2525782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Lee, Jongeun</creatorcontrib><creatorcontrib>Huang, Bing S.</creatorcontrib><creatorcontrib>Grekin, Roger J.</creatorcontrib><creatorcontrib>Malvin, Richard L.</creatorcontrib><title>Clonidine and Morphine Increase Atrial Natriuretic Peptide Secretion in Anesthetized Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
In order to determine whether the activity of central α
2-adrenergic and opioid receptors influence plasma atrial natriuretic peptide (ANP) levels, clonidine and morphine were infused into the lateral cerebral ventricle for 45 min in anesthetized Sprague-Dawley rats. The central administration of a low dose of clonidine (10 ng/min) caused a significant increase in plasma ANP without changing arterial blood pressure or central venous pressure. Pretreatment with yohimbine (5 μg/min) completely blocked the effect of clonidine. Central infusion of morphine (100 ng/min) also elevated plasma ANP levels and naloxone (5 μg/min) blunted this effect. Intravenous infusion of the same dose of clonidine or morphine did not affect plasma ANP levels. Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 μg/min). These results suggest that central α
2-adrenergic and opioid receptors may be involved in ANP secretion.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>atrial natriuretic hormone</subject><subject>Clonidine - administration & dosage</subject><subject>Clonidine - pharmacology</subject><subject>heart</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - pharmacology</subject><subject>opiates</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhi0EglJ4ASQkn7gFvCWOj1XFUolNLAdOlmMPNFXqFDs5wNPj0MIRTqOZ-ebX6EPoiJJTTkt6RgiXSjKZUUUzwRQTW2hEc55nvFBqG40GIBuIPbQf44IQmktW7KJdlrNclmyEXqZN62tXe8DGO3zThtV8aGbeBjAR8KQLtWnwrUm1D9DVFt_Dqqsd4Eeww6D1uPZ44iF289R-gsMPposHaOfVNBEON3WMni_On6ZX2fXd5Ww6uc5serLLSiskVYWoSlI6aZmsnORSVJUCIUnFhKWMKyEcyZUTTljjqOECKkssY0TwMTpZ565C-96nJ_Syjhaaxnho-6ilIlIpVvwL0lwUVHGaQLYGbWhjDPCqV6FemvChKdGDeP0jXifx-lt8OjrepPfVEtzvycZ02p-t99G8gV60ffDJyl-JX9Xci0E</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Chen, Min</creator><creator>Lee, Jongeun</creator><creator>Huang, Bing S.</creator><creator>Grekin, Roger J.</creator><creator>Malvin, Richard L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Clonidine and Morphine Increase Atrial Natriuretic Peptide Secretion in Anesthetized Rats</title><author>Chen, Min ; Lee, Jongeun ; Huang, Bing S. ; Grekin, Roger J. ; Malvin, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-8c471964b808d7c27bd7374bb9e470b24c123944d059d4d4cad1a34ebc0c22043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>atrial natriuretic hormone</topic><topic>Clonidine - administration & dosage</topic><topic>Clonidine - pharmacology</topic><topic>heart</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - pharmacology</topic><topic>opiates</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Lee, Jongeun</creatorcontrib><creatorcontrib>Huang, Bing S.</creatorcontrib><creatorcontrib>Grekin, Roger J.</creatorcontrib><creatorcontrib>Malvin, Richard L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Min</au><au>Lee, Jongeun</au><au>Huang, Bing S.</au><au>Grekin, Roger J.</au><au>Malvin, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clonidine and Morphine Increase Atrial Natriuretic Peptide Secretion in Anesthetized Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>191</volume><issue>3</issue><spage>299</spage><epage>303</epage><pages>299-303</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Abstract
In order to determine whether the activity of central α
2-adrenergic and opioid receptors influence plasma atrial natriuretic peptide (ANP) levels, clonidine and morphine were infused into the lateral cerebral ventricle for 45 min in anesthetized Sprague-Dawley rats. The central administration of a low dose of clonidine (10 ng/min) caused a significant increase in plasma ANP without changing arterial blood pressure or central venous pressure. Pretreatment with yohimbine (5 μg/min) completely blocked the effect of clonidine. Central infusion of morphine (100 ng/min) also elevated plasma ANP levels and naloxone (5 μg/min) blunted this effect. Intravenous infusion of the same dose of clonidine or morphine did not affect plasma ANP levels. Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 μg/min). These results suggest that central α
2-adrenergic and opioid receptors may be involved in ANP secretion.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2525782</pmid><doi>10.3181/00379727-191-42924</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1989-07, Vol.191 (3), p.299-303 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anesthesia Animals Atrial Natriuretic Factor - metabolism atrial natriuretic hormone Clonidine - administration & dosage Clonidine - pharmacology heart Injections, Intraventricular Male Morphine - administration & dosage Morphine - pharmacology opiates Rats Rats, Inbred Strains |
| title | Clonidine and Morphine Increase Atrial Natriuretic Peptide Secretion in Anesthetized Rats |
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