Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: Ultrastructural and immunohistochemical study and review of the literature
The first reported case of an intraarticular malignant giant cell tumor of synovium studied with electron microscopic and immunohistochemical examination is presented, together with a case of diffuse intraarticular pigmented villonodular synovitis with extensive bone destruction. The malignant case...
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| Veröffentlicht in: | Human pathology 1989-08, Vol.20 (8), p.765-771 |
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| container_title | Human pathology |
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| creator | Nielsen, Anette Lynge Kiær, Thomas |
| description | The first reported case of an intraarticular malignant giant cell tumor of synovium studied with electron microscopic and immunohistochemical examination is presented, together with a case of diffuse intraarticular pigmented villonodular synovitis with extensive bone destruction. The malignant case was dominated by uniform cells positive for histiocytic markers, the fine structure showing a gradual change from cells dominated by organelles serving a secretory function to cells with phagocytic activity. The reported cases of giant cell tumor of the tendon sheath indicate that the pertinent histologic changes regarding malignancy are an increase in cell polymorphism and in the number of mitoses, and a decrease in the number of multinucleated giant cells. |
| doi_str_mv | 10.1016/0046-8177(89)90070-1 |
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The malignant case was dominated by uniform cells positive for histiocytic markers, the fine structure showing a gradual change from cells dominated by organelles serving a secretory function to cells with phagocytic activity. 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Kiær, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-1789a6e641979a0769b95467ad815adce7dba05b1b84f61fa8a13b8a8f1199fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Joint Diseases - complications</topic><topic>Joint Diseases - pathology</topic><topic>Male</topic><topic>malignant germ cell tumor of synovium</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>pigmented villonodular synovitis</topic><topic>sarcoma joint</topic><topic>Sarcoma, Synovial - analysis</topic><topic>Sarcoma, Synovial - complications</topic><topic>Sarcoma, Synovial - ultrastructure</topic><topic>Synovial Membrane - ultrastructure</topic><topic>synovial neoplasm</topic><topic>Synovitis - pathology</topic><topic>Synovitis, Pigmented Villonodular - complications</topic><topic>Synovitis, Pigmented Villonodular - pathology</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nielsen, Anette Lynge</creatorcontrib><creatorcontrib>Kiær, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nielsen, Anette Lynge</au><au>Kiær, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: Ultrastructural and immunohistochemical study and review of the literature</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>20</volume><issue>8</issue><spage>765</spage><epage>771</epage><pages>765-771</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>The first reported case of an intraarticular malignant giant cell tumor of synovium studied with electron microscopic and immunohistochemical examination is presented, together with a case of diffuse intraarticular pigmented villonodular synovitis with extensive bone destruction. The malignant case was dominated by uniform cells positive for histiocytic markers, the fine structure showing a gradual change from cells dominated by organelles serving a secretory function to cells with phagocytic activity. The reported cases of giant cell tumor of the tendon sheath indicate that the pertinent histologic changes regarding malignancy are an increase in cell polymorphism and in the number of mitoses, and a decrease in the number of multinucleated giant cells.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2545593</pmid><doi>10.1016/0046-8177(89)90070-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Human pathology, 1989-08, Vol.20 (8), p.765-771 |
| issn | 0046-8177 1532-8392 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Biological and medical sciences Diseases of the osteoarticular system Female Humans Immunohistochemistry Joint Diseases - complications Joint Diseases - pathology Male malignant germ cell tumor of synovium Medical sciences Microscopy, Electron pigmented villonodular synovitis sarcoma joint Sarcoma, Synovial - analysis Sarcoma, Synovial - complications Sarcoma, Synovial - ultrastructure Synovial Membrane - ultrastructure synovial neoplasm Synovitis - pathology Synovitis, Pigmented Villonodular - complications Synovitis, Pigmented Villonodular - pathology Tumors of striated muscle and skeleton |
| title | Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: Ultrastructural and immunohistochemical study and review of the literature |
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