Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children
BACKGROUND.Acute otitis media is the leading reason for antibiotic prescriptions in childhood. The increase in antibiotic resistance of Streptococcus pneumoniae is generally attributed to the extensive use of antibiotics and the selective pressure on the bacterial strains of the nasopharyngeal flora...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1997-06, Vol.16 (6), p.555-560 |
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| creator | COHEN, ROBERT BINGEN, EDOUARD VARON, EMMANUELLE DE LA ROCQUE, FRANCE BRAHIMI, NAHIMA LEVY, CORINNE BOUCHERAT, MICHEL LANGUE, JACQUES GESLIN, PIERRE |
| description | BACKGROUND.Acute otitis media is the leading reason for antibiotic prescriptions in childhood. The increase in antibiotic resistance of Streptococcus pneumoniae is generally attributed to the extensive use of antibiotics and the selective pressure on the bacterial strains of the nasopharyngeal flora.
OBJECTIVE.To evaluate the change in nasopharyngeal carriage of S. pneumoniae during antibiotic therapy prescribed for acute otitis media.
METHODS.Between October, 1993, and March, 1994, we conducted a clinical trial comparing cefpodoxime-proxetil and amoxicillin-clavulanate in acute otitis media. From 364 children, 4 months to 4.5 years old, a nasopharyngeal sample was obtained before and after treatment. Antibiotic susceptibility was established by determining minimal inhibitory concentrations by the agar dilution method. Serotype and randomly amplified polymorphic DNA analysis were used to compare pre- and posttreatment S. pneumoniae strains.
RESULTS.The risk for a child to carry penicillin-resistant S. pneumoniae (MIC ≥ 0.125 mg/l) did not increase after antibiotic treatment84 of 364 (23.1%) before, 70 of 364 (19.2%) after. There was a significant decrease of penicillin-susceptible S. pneumoniae carriage, 117 of 364 (32.1%) before treatment compared with 24 of 364 (6.6%) (P = 0.0001) after treatment. However, among the children carrying S. pneumoniae at the end of the treatment there was an increase in the percentage of penicillin-resistant pneumococci84 of 201 (41.8%) before treatment and 70 of 94 (74.5%) after treatment. Among the 94 children carrying S. pneumoniae at the end of the treatment, 22 did not harbor pneumococcus before, 16 carried another genotypically different serotype and 56 harbored the same serotype. Among these 56 children 2 patients harbored strains that had increased MICs for the tested beta-lactam antibiotics. The randomly amplified polymorphic DNA analysis showed that in one case, the strains were genetically different.
CONCLUSIONS.These data illustrate that antibiotic therapy did not increase the rate at which children carried penicillin-resistant S. pneumoniae, but there was an increase in the rate of resistance among the children carrying pneumococci at the end of the treatment, mainly as a result of reduction of susceptible strains. |
| doi_str_mv | 10.1097/00006454-199706000-00004 |
| format | Article |
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OBJECTIVE.To evaluate the change in nasopharyngeal carriage of S. pneumoniae during antibiotic therapy prescribed for acute otitis media.
METHODS.Between October, 1993, and March, 1994, we conducted a clinical trial comparing cefpodoxime-proxetil and amoxicillin-clavulanate in acute otitis media. From 364 children, 4 months to 4.5 years old, a nasopharyngeal sample was obtained before and after treatment. Antibiotic susceptibility was established by determining minimal inhibitory concentrations by the agar dilution method. Serotype and randomly amplified polymorphic DNA analysis were used to compare pre- and posttreatment S. pneumoniae strains.
RESULTS.The risk for a child to carry penicillin-resistant S. pneumoniae (MIC ≥ 0.125 mg/l) did not increase after antibiotic treatment84 of 364 (23.1%) before, 70 of 364 (19.2%) after. There was a significant decrease of penicillin-susceptible S. pneumoniae carriage, 117 of 364 (32.1%) before treatment compared with 24 of 364 (6.6%) (P = 0.0001) after treatment. However, among the children carrying S. pneumoniae at the end of the treatment there was an increase in the percentage of penicillin-resistant pneumococci84 of 201 (41.8%) before treatment and 70 of 94 (74.5%) after treatment. Among the 94 children carrying S. pneumoniae at the end of the treatment, 22 did not harbor pneumococcus before, 16 carried another genotypically different serotype and 56 harbored the same serotype. Among these 56 children 2 patients harbored strains that had increased MICs for the tested beta-lactam antibiotics. The randomly amplified polymorphic DNA analysis showed that in one case, the strains were genetically different.
CONCLUSIONS.These data illustrate that antibiotic therapy did not increase the rate at which children carried penicillin-resistant S. pneumoniae, but there was an increase in the rate of resistance among the children carrying pneumococci at the end of the treatment, mainly as a result of reduction of susceptible strains.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-199706000-00004</identifier><identifier>PMID: 9194104</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Acute Disease ; Amoxicillin - therapeutic use ; Amoxicillin-Potassium Clavulanate Combination ; Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Cefpodoxime Proxetil ; Ceftizoxime - analogs & derivatives ; Ceftizoxime - therapeutic use ; Child, Preschool ; Clavulanic Acids - therapeutic use ; Ent and stomatologic bacterial diseases ; Female ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Nasopharynx - microbiology ; Otitis Media - drug therapy ; Otitis Media - microbiology ; Penicillin Resistance ; Prospective Studies ; Streptococcus pneumoniae - drug effects</subject><ispartof>The Pediatric infectious disease journal, 1997-06, Vol.16 (6), p.555-560</ispartof><rights>Williams & Wilkins 1997. All Rights Reserved.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4154-623049b13c7c7dcfaca535fa605136e45addc1979ff3b8f94a36901bf21b6bff3</citedby><cites>FETCH-LOGICAL-c4154-623049b13c7c7dcfaca535fa605136e45addc1979ff3b8f94a36901bf21b6bff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2702659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9194104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COHEN, ROBERT</creatorcontrib><creatorcontrib>BINGEN, EDOUARD</creatorcontrib><creatorcontrib>VARON, EMMANUELLE</creatorcontrib><creatorcontrib>DE LA ROCQUE, FRANCE</creatorcontrib><creatorcontrib>BRAHIMI, NAHIMA</creatorcontrib><creatorcontrib>LEVY, CORINNE</creatorcontrib><creatorcontrib>BOUCHERAT, MICHEL</creatorcontrib><creatorcontrib>LANGUE, JACQUES</creatorcontrib><creatorcontrib>GESLIN, PIERRE</creatorcontrib><title>Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND.Acute otitis media is the leading reason for antibiotic prescriptions in childhood. The increase in antibiotic resistance of Streptococcus pneumoniae is generally attributed to the extensive use of antibiotics and the selective pressure on the bacterial strains of the nasopharyngeal flora.
OBJECTIVE.To evaluate the change in nasopharyngeal carriage of S. pneumoniae during antibiotic therapy prescribed for acute otitis media.
METHODS.Between October, 1993, and March, 1994, we conducted a clinical trial comparing cefpodoxime-proxetil and amoxicillin-clavulanate in acute otitis media. From 364 children, 4 months to 4.5 years old, a nasopharyngeal sample was obtained before and after treatment. Antibiotic susceptibility was established by determining minimal inhibitory concentrations by the agar dilution method. Serotype and randomly amplified polymorphic DNA analysis were used to compare pre- and posttreatment S. pneumoniae strains.
RESULTS.The risk for a child to carry penicillin-resistant S. pneumoniae (MIC ≥ 0.125 mg/l) did not increase after antibiotic treatment84 of 364 (23.1%) before, 70 of 364 (19.2%) after. There was a significant decrease of penicillin-susceptible S. pneumoniae carriage, 117 of 364 (32.1%) before treatment compared with 24 of 364 (6.6%) (P = 0.0001) after treatment. However, among the children carrying S. pneumoniae at the end of the treatment there was an increase in the percentage of penicillin-resistant pneumococci84 of 201 (41.8%) before treatment and 70 of 94 (74.5%) after treatment. Among the 94 children carrying S. pneumoniae at the end of the treatment, 22 did not harbor pneumococcus before, 16 carried another genotypically different serotype and 56 harbored the same serotype. Among these 56 children 2 patients harbored strains that had increased MICs for the tested beta-lactam antibiotics. The randomly amplified polymorphic DNA analysis showed that in one case, the strains were genetically different.
CONCLUSIONS.These data illustrate that antibiotic therapy did not increase the rate at which children carried penicillin-resistant S. pneumoniae, but there was an increase in the rate of resistance among the children carrying pneumococci at the end of the treatment, mainly as a result of reduction of susceptible strains.</description><subject>Acute Disease</subject><subject>Amoxicillin - therapeutic use</subject><subject>Amoxicillin-Potassium Clavulanate Combination</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cefpodoxime Proxetil</subject><subject>Ceftizoxime - analogs & derivatives</subject><subject>Ceftizoxime - therapeutic use</subject><subject>Child, Preschool</subject><subject>Clavulanic Acids - therapeutic use</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasopharynx - microbiology</subject><subject>Otitis Media - drug therapy</subject><subject>Otitis Media - microbiology</subject><subject>Penicillin Resistance</subject><subject>Prospective Studies</subject><subject>Streptococcus pneumoniae - drug effects</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFvFSEQx4mxqc-2H8GEg_G2CgsLy9G8WDVp4kF7JrMsdNFdWIFN06ufXJ7v-W5GLjAzv5nJzB-EMCVvKVHyHalH8I43VClJRLWag4s_QzvasbYhqpfP0Y70ijZMiP4Fepnz90owTsklulRU1QffoV_7CcKDxT7gADmuE6SnasOMDaTkoYaiw19LsmuJJhqzZbwGuy0xeLA42bzNxYcH7FJcMITiBx-LN7hMNsH6hF1MGMxWap3ii894saOHQz8z-XlMNlyjCwdztjen-wrd3374tv_U3H35-Hn__q4xnNZJRcsIVwNlRho5GgcGOtY5EKSjTFjewTgaqqRyjg29UxyYUIQOrqWDGKrzCr051l1T_LnZXPTis7HzDMHGLWupiFRtx_4LUtHSuskD2B9Bk2LOyTq9Jr_UDWpK9EEn_Vcnfdbpj4vX1FenHttQN3JOPAlT469PccgGZpcgGJ_PWCtJKzpVMX7EHuNcbMo_5u3RJj1VAcuk__VL2G_mPqze</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>COHEN, ROBERT</creator><creator>BINGEN, EDOUARD</creator><creator>VARON, EMMANUELLE</creator><creator>DE LA ROCQUE, FRANCE</creator><creator>BRAHIMI, NAHIMA</creator><creator>LEVY, CORINNE</creator><creator>BOUCHERAT, MICHEL</creator><creator>LANGUE, JACQUES</creator><creator>GESLIN, PIERRE</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>199706</creationdate><title>Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children</title><author>COHEN, ROBERT ; BINGEN, EDOUARD ; VARON, EMMANUELLE ; DE LA ROCQUE, FRANCE ; BRAHIMI, NAHIMA ; LEVY, CORINNE ; BOUCHERAT, MICHEL ; LANGUE, JACQUES ; GESLIN, PIERRE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4154-623049b13c7c7dcfaca535fa605136e45addc1979ff3b8f94a36901bf21b6bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Amoxicillin - therapeutic use</topic><topic>Amoxicillin-Potassium Clavulanate Combination</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cefpodoxime Proxetil</topic><topic>Ceftizoxime - analogs & derivatives</topic><topic>Ceftizoxime - therapeutic use</topic><topic>Child, Preschool</topic><topic>Clavulanic Acids - therapeutic use</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasopharynx - microbiology</topic><topic>Otitis Media - drug therapy</topic><topic>Otitis Media - microbiology</topic><topic>Penicillin Resistance</topic><topic>Prospective Studies</topic><topic>Streptococcus pneumoniae - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COHEN, ROBERT</creatorcontrib><creatorcontrib>BINGEN, EDOUARD</creatorcontrib><creatorcontrib>VARON, EMMANUELLE</creatorcontrib><creatorcontrib>DE LA ROCQUE, FRANCE</creatorcontrib><creatorcontrib>BRAHIMI, NAHIMA</creatorcontrib><creatorcontrib>LEVY, CORINNE</creatorcontrib><creatorcontrib>BOUCHERAT, MICHEL</creatorcontrib><creatorcontrib>LANGUE, JACQUES</creatorcontrib><creatorcontrib>GESLIN, PIERRE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COHEN, ROBERT</au><au>BINGEN, EDOUARD</au><au>VARON, EMMANUELLE</au><au>DE LA ROCQUE, FRANCE</au><au>BRAHIMI, NAHIMA</au><au>LEVY, CORINNE</au><au>BOUCHERAT, MICHEL</au><au>LANGUE, JACQUES</au><au>GESLIN, PIERRE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>1997-06</date><risdate>1997</risdate><volume>16</volume><issue>6</issue><spage>555</spage><epage>560</epage><pages>555-560</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND.Acute otitis media is the leading reason for antibiotic prescriptions in childhood. The increase in antibiotic resistance of Streptococcus pneumoniae is generally attributed to the extensive use of antibiotics and the selective pressure on the bacterial strains of the nasopharyngeal flora.
OBJECTIVE.To evaluate the change in nasopharyngeal carriage of S. pneumoniae during antibiotic therapy prescribed for acute otitis media.
METHODS.Between October, 1993, and March, 1994, we conducted a clinical trial comparing cefpodoxime-proxetil and amoxicillin-clavulanate in acute otitis media. From 364 children, 4 months to 4.5 years old, a nasopharyngeal sample was obtained before and after treatment. Antibiotic susceptibility was established by determining minimal inhibitory concentrations by the agar dilution method. Serotype and randomly amplified polymorphic DNA analysis were used to compare pre- and posttreatment S. pneumoniae strains.
RESULTS.The risk for a child to carry penicillin-resistant S. pneumoniae (MIC ≥ 0.125 mg/l) did not increase after antibiotic treatment84 of 364 (23.1%) before, 70 of 364 (19.2%) after. There was a significant decrease of penicillin-susceptible S. pneumoniae carriage, 117 of 364 (32.1%) before treatment compared with 24 of 364 (6.6%) (P = 0.0001) after treatment. However, among the children carrying S. pneumoniae at the end of the treatment there was an increase in the percentage of penicillin-resistant pneumococci84 of 201 (41.8%) before treatment and 70 of 94 (74.5%) after treatment. Among the 94 children carrying S. pneumoniae at the end of the treatment, 22 did not harbor pneumococcus before, 16 carried another genotypically different serotype and 56 harbored the same serotype. Among these 56 children 2 patients harbored strains that had increased MICs for the tested beta-lactam antibiotics. The randomly amplified polymorphic DNA analysis showed that in one case, the strains were genetically different.
CONCLUSIONS.These data illustrate that antibiotic therapy did not increase the rate at which children carried penicillin-resistant S. pneumoniae, but there was an increase in the rate of resistance among the children carrying pneumococci at the end of the treatment, mainly as a result of reduction of susceptible strains.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>9194104</pmid><doi>10.1097/00006454-199706000-00004</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Pediatric infectious disease journal, 1997-06, Vol.16 (6), p.555-560 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acute Disease Amoxicillin - therapeutic use Amoxicillin-Potassium Clavulanate Combination Anti-Bacterial Agents - therapeutic use Bacterial diseases Biological and medical sciences Cefpodoxime Proxetil Ceftizoxime - analogs & derivatives Ceftizoxime - therapeutic use Child, Preschool Clavulanic Acids - therapeutic use Ent and stomatologic bacterial diseases Female Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Nasopharynx - microbiology Otitis Media - drug therapy Otitis Media - microbiology Penicillin Resistance Prospective Studies Streptococcus pneumoniae - drug effects |
| title | Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children |
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