Substrate variability as a factor in enzyme inhibitor design: inhibition of ovine brain glutamine synthetase by .alpha.- and .gamma.-substituted phosphinothricins

Ovine brain glutamine synthetase (GS) utilizes various substituted glutamic acids as substrates. We have used this information to design alpha- and gamma-substituted analogues of phosphinothricin [L-2-amino-4-(hydroxymethylphosphinyl)butanoic acid], a naturally occurring inhibitor of GS. These compo...

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