Studies on the beneficial effect of levocarnitine chloride (LC-80) on organic acidemias, especially propionic acidemia and methylmalonic acidemia

The beneficial effect of LC-80 in the therapy for organic acidemias, especially propionic acidemia and methylmalonic acidemia, was compared with those of its optical isomers, d-carnitine chloride (d-isomer) and dl-carnitine chloride (dl-isomer) in rat liver mitochondria. LC-80 at concentrations of 5...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1989, Vol.93(5), pp.305-314
Hauptverfasser:	FUJISAWA, Shigeki, SHIMATANI, Keiko, YAMADA, Hiroaki, HIRONAKA, Yutaka
Format:	Artikel
Sprache:	jpn
Schlagworte:	Amino Acid Metabolism, Inborn Errors - drug therapy Animals Carnitine - pharmacology Carnitine - therapeutic use Drug Evaluation, Preclinical Isomerism Malonates - blood Methylmalonic Acid - blood Mitochondria, Liver - physiology Oxygen Consumption - drug effects Propionates - blood Rats Rats, Inbred Strains Structure-Activity Relationship
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