Thyroid hormone concentrations in epileptic patients
Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healt...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical pharmacology 1989-01, Vol.36 (3), p.213-216 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 216 |
|---|---|
| container_issue | 3 |
| container_start_page | 213 |
| container_title | European journal of clinical pharmacology |
| container_volume | 36 |
| creator | LARKIN, J. G MACPHEE, G. J. A BEASTALL, G. H BRODIE, M. J |
| description | Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volunteers were included as controls. Total thyroxine (T4) concentrations were reduced in patients taking enzyme-inducing drugs (carbamazepine and/or phenytoin) compared with both controls and patients taking sodium valproate. Similar differences were shown with each individual drug. All nine patients whose circulating T4 was below the lower limit of the reference range were taking enzyme inducers. Free thyroxine concentrations were also reduced in individuals treated with carbamazepine and phenytoin with five values falling beneath the reference range. Tri-iodothyronine and thyrotropin appeared unaffected by anticonvulsant administration. Thyrotropin releasing hormone stimulation revealed no true hypothyroidism. The lowering effect of anticonvulsant drugs on circulating total and free T4 was not exhibited by the non-inducing sodium valproate. These data support the influence of enzyme induction as a likely mechanism for reduced thyroxine concentrations in treated epileptic patients. |
| doi_str_mv | 10.1007/BF00558149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79073556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79073556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-5b1661808ceb99801a7573a73d749bd1b1ca5313a235062e6a9d8e520719cd2c3</originalsourceid><addsrcrecordid>eNpFkDFPwzAQhS0EKqWwsCNlQAxIgTs7juORVhSQKrGUOXIcVzVK7GAnQ_89QY3KdNK9773hI-QW4QkBxPNyDcB5gZk8I3PMGE0RMjwncwCGaS4FXJKrGL8BkEtgMzKjHHCszkm23R-Ct3Wy96H1ziTaO21cH1RvvYuJdYnpbGO63uqkG59jFq_JxU410dxMd0G-1q_b1Xu6-Xz7WL1sUs0Q-5RXmOdYQKFNJWUBqAQXTAlWi0xWNVaoFWfIFGUccmpyJevCcAoCpa6pZgvycNztgv8ZTOzL1kZtmkY544dYCgmCcZ6P4OMR1MHHGMyu7IJtVTiUCOWfovJf0QjfTatD1Zr6hE5Oxvx-ylXUqtkF5bSNJ0xQAVxw9gvnn2uo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79073556</pqid></control><display><type>article</type><title>Thyroid hormone concentrations in epileptic patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>LARKIN, J. G ; MACPHEE, G. J. A ; BEASTALL, G. H ; BRODIE, M. J</creator><creatorcontrib>LARKIN, J. G ; MACPHEE, G. J. A ; BEASTALL, G. H ; BRODIE, M. J</creatorcontrib><description>Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volunteers were included as controls. Total thyroxine (T4) concentrations were reduced in patients taking enzyme-inducing drugs (carbamazepine and/or phenytoin) compared with both controls and patients taking sodium valproate. Similar differences were shown with each individual drug. All nine patients whose circulating T4 was below the lower limit of the reference range were taking enzyme inducers. Free thyroxine concentrations were also reduced in individuals treated with carbamazepine and phenytoin with five values falling beneath the reference range. Tri-iodothyronine and thyrotropin appeared unaffected by anticonvulsant administration. Thyrotropin releasing hormone stimulation revealed no true hypothyroidism. The lowering effect of anticonvulsant drugs on circulating total and free T4 was not exhibited by the non-inducing sodium valproate. These data support the influence of enzyme induction as a likely mechanism for reduced thyroxine concentrations in treated epileptic patients.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00558149</identifier><identifier>PMID: 2501100</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Carbamazepine - therapeutic use ; Drug Combinations ; Epilepsy - blood ; Epilepsy - drug therapy ; Humans ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Phenytoin - therapeutic use ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood ; Valproic Acid - therapeutic use</subject><ispartof>European journal of clinical pharmacology, 1989-01, Vol.36 (3), p.213-216</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-5b1661808ceb99801a7573a73d749bd1b1ca5313a235062e6a9d8e520719cd2c3</citedby><cites>FETCH-LOGICAL-c311t-5b1661808ceb99801a7573a73d749bd1b1ca5313a235062e6a9d8e520719cd2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7270575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2501100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LARKIN, J. G</creatorcontrib><creatorcontrib>MACPHEE, G. J. A</creatorcontrib><creatorcontrib>BEASTALL, G. H</creatorcontrib><creatorcontrib>BRODIE, M. J</creatorcontrib><title>Thyroid hormone concentrations in epileptic patients</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volunteers were included as controls. Total thyroxine (T4) concentrations were reduced in patients taking enzyme-inducing drugs (carbamazepine and/or phenytoin) compared with both controls and patients taking sodium valproate. Similar differences were shown with each individual drug. All nine patients whose circulating T4 was below the lower limit of the reference range were taking enzyme inducers. Free thyroxine concentrations were also reduced in individuals treated with carbamazepine and phenytoin with five values falling beneath the reference range. Tri-iodothyronine and thyrotropin appeared unaffected by anticonvulsant administration. Thyrotropin releasing hormone stimulation revealed no true hypothyroidism. The lowering effect of anticonvulsant drugs on circulating total and free T4 was not exhibited by the non-inducing sodium valproate. These data support the influence of enzyme induction as a likely mechanism for reduced thyroxine concentrations in treated epileptic patients.</description><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Carbamazepine - therapeutic use</subject><subject>Drug Combinations</subject><subject>Epilepsy - blood</subject><subject>Epilepsy - drug therapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenytoin - therapeutic use</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><subject>Valproic Acid - therapeutic use</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQhS0EKqWwsCNlQAxIgTs7juORVhSQKrGUOXIcVzVK7GAnQ_89QY3KdNK9773hI-QW4QkBxPNyDcB5gZk8I3PMGE0RMjwncwCGaS4FXJKrGL8BkEtgMzKjHHCszkm23R-Ct3Wy96H1ziTaO21cH1RvvYuJdYnpbGO63uqkG59jFq_JxU410dxMd0G-1q_b1Xu6-Xz7WL1sUs0Q-5RXmOdYQKFNJWUBqAQXTAlWi0xWNVaoFWfIFGUccmpyJevCcAoCpa6pZgvycNztgv8ZTOzL1kZtmkY544dYCgmCcZ6P4OMR1MHHGMyu7IJtVTiUCOWfovJf0QjfTatD1Zr6hE5Oxvx-ylXUqtkF5bSNJ0xQAVxw9gvnn2uo</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>LARKIN, J. G</creator><creator>MACPHEE, G. J. A</creator><creator>BEASTALL, G. H</creator><creator>BRODIE, M. J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Thyroid hormone concentrations in epileptic patients</title><author>LARKIN, J. G ; MACPHEE, G. J. A ; BEASTALL, G. H ; BRODIE, M. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-5b1661808ceb99801a7573a73d749bd1b1ca5313a235062e6a9d8e520719cd2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Carbamazepine - therapeutic use</topic><topic>Drug Combinations</topic><topic>Epilepsy - blood</topic><topic>Epilepsy - drug therapy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenytoin - therapeutic use</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><topic>Valproic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LARKIN, J. G</creatorcontrib><creatorcontrib>MACPHEE, G. J. A</creatorcontrib><creatorcontrib>BEASTALL, G. H</creatorcontrib><creatorcontrib>BRODIE, M. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LARKIN, J. G</au><au>MACPHEE, G. J. A</au><au>BEASTALL, G. H</au><au>BRODIE, M. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid hormone concentrations in epileptic patients</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>36</volume><issue>3</issue><spage>213</spage><epage>216</epage><pages>213-216</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volunteers were included as controls. Total thyroxine (T4) concentrations were reduced in patients taking enzyme-inducing drugs (carbamazepine and/or phenytoin) compared with both controls and patients taking sodium valproate. Similar differences were shown with each individual drug. All nine patients whose circulating T4 was below the lower limit of the reference range were taking enzyme inducers. Free thyroxine concentrations were also reduced in individuals treated with carbamazepine and phenytoin with five values falling beneath the reference range. Tri-iodothyronine and thyrotropin appeared unaffected by anticonvulsant administration. Thyrotropin releasing hormone stimulation revealed no true hypothyroidism. The lowering effect of anticonvulsant drugs on circulating total and free T4 was not exhibited by the non-inducing sodium valproate. These data support the influence of enzyme induction as a likely mechanism for reduced thyroxine concentrations in treated epileptic patients.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2501100</pmid><doi>10.1007/BF00558149</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1989-01, Vol.36 (3), p.213-216 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79073556 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Carbamazepine - therapeutic use Drug Combinations Epilepsy - blood Epilepsy - drug therapy Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Phenytoin - therapeutic use Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood Valproic Acid - therapeutic use |
| title | Thyroid hormone concentrations in epileptic patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T17%3A58%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thyroid%20hormone%20concentrations%20in%20epileptic%20patients&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=LARKIN,%20J.%20G&rft.date=1989-01-01&rft.volume=36&rft.issue=3&rft.spage=213&rft.epage=216&rft.pages=213-216&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/BF00558149&rft_dat=%3Cproquest_cross%3E79073556%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79073556&rft_id=info:pmid/2501100&rfr_iscdi=true |