Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion

Background: The single genetic factor most strongly correlated with reduced alcohol consumption and incidence of alcoholism is a naturally occurring variant of mitochondrial aldehyde dehydrogenase (ALDH2). This variant contains a glutamate to lysine substitution at position 487 (E487K). The E487K va...

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Veröffentlicht in:	Structure (London) 1997-05, Vol.5 (5), p.701-711
Hauptverfasser:	Steinmetz, Curtis G, Xie, Peiguang, Weiner, Henry, Hurley, Thomas D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - genetics aldehyde dehydrogenase Aldehyde Dehydrogenase - chemistry Aldehyde Dehydrogenase, Mitochondrial Animals Binding Sites Cattle Crystallography, X-Ray dinucleotide fold Enzyme Stability Glutamic Acid - chemistry Mitochondria - enzymology Models, Molecular Molecular Sequence Data multiple isomorphous replacement NAD - chemistry phenotypic dominance Protein Conformation
Online-Zugang:	Volltext
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