Defibrotide augments the anticandidial activity of NK cells
1. 1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin. 2. 2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined tha...
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| Veröffentlicht in: | General pharmacology 1997-05, Vol.28 (5), p.733-735 |
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| container_end_page | 735 |
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| container_issue | 5 |
| container_start_page | 733 |
| container_title | General pharmacology |
| container_volume | 28 |
| creator | Turhan, Aslihan Piskin, Ayse Kevser Emerk, Kaya Imir, Turgut |
| description | 1.
1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin.
2.
2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect.
3.
3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity.
4.
4. It is concluded that defibrotide is a potent activator of NK cells. |
| doi_str_mv | 10.1016/S0306-3623(96)00311-4 |
| format | Article |
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1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin.
2.
2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect.
3.
3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity.
4.
4. It is concluded that defibrotide is a potent activator of NK cells.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/S0306-3623(96)00311-4</identifier><identifier>PMID: 9184811</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Candida albicans - growth & development ; Candida albicans - immunology ; Cytotoxicity, Immunologic - drug effects ; Fibrinolytic Agents - pharmacology ; Gallic Acid - analogs & derivatives ; Gallic Acid - pharmacology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Pertussis Toxin ; Pharmacology. Drug treatments ; Polydeoxyribonucleotides - pharmacology ; Stimulation, Chemical ; Verapamil - pharmacology ; Virulence Factors, Bordetella - pharmacology</subject><ispartof>General pharmacology, 1997-05, Vol.28 (5), p.733-735</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-acdaa1455dd6949ba2f20e47175bb706019a9ad672e10e855f02a8df7a4264603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2697111$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9184811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turhan, Aslihan</creatorcontrib><creatorcontrib>Piskin, Ayse Kevser</creatorcontrib><creatorcontrib>Emerk, Kaya</creatorcontrib><creatorcontrib>Imir, Turgut</creatorcontrib><title>Defibrotide augments the anticandidial activity of NK cells</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin.
2.
2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect.
3.
3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity.
4.
4. It is concluded that defibrotide is a potent activator of NK cells.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Candida albicans - growth & development</subject><subject>Candida albicans - immunology</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Gallic Acid - analogs & derivatives</subject><subject>Gallic Acid - pharmacology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pertussis Toxin</subject><subject>Pharmacology. Drug treatments</subject><subject>Polydeoxyribonucleotides - pharmacology</subject><subject>Stimulation, Chemical</subject><subject>Verapamil - pharmacology</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1EVZbCT6iUA0JwSJlxHDsWB4TKV9UKDsDZmtgTMMomre2t1H9P9kN77Wk0mmdmXj1CnCNcIKB-9xMa0HWjZfPG6rcADWKtnogVdsbWAIhPxeqIPBPPc_4HALKV8lScWuxUh7gS7z_xEPs0lxi4os2fNU8lV-Xv0kwleppCDJHGinyJ97E8VPNQfb-uPI9jfiFOBhozvzzUM_H7y-dfl9_qmx9fry4_3tS-0V2pyQciVG0bgrbK9iQHCawMmrbvDWhAS5aCNpIRuGvbASR1YTCkpFYamjPxen_3Ns13G87FrWPeJqCJ5012xoLBDh8HUTctgmoWsN2DPs05Jx7cbYprSg8OwW3tup1dt1XnrHY7u04te-eHB5t-zeG4ddC5zF8d5pQ9jUOiycd8xKS2BnfYhz3Gi7X7yMllH3nyHGJiX1yY4yNB_gME4ZRa</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Turhan, Aslihan</creator><creator>Piskin, Ayse Kevser</creator><creator>Emerk, Kaya</creator><creator>Imir, Turgut</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Defibrotide augments the anticandidial activity of NK cells</title><author>Turhan, Aslihan ; Piskin, Ayse Kevser ; Emerk, Kaya ; Imir, Turgut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-acdaa1455dd6949ba2f20e47175bb706019a9ad672e10e855f02a8df7a4264603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Candida albicans - growth & development</topic><topic>Candida albicans - immunology</topic><topic>Cytotoxicity, Immunologic - drug effects</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Gallic Acid - analogs & derivatives</topic><topic>Gallic Acid - pharmacology</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Pertussis Toxin</topic><topic>Pharmacology. Drug treatments</topic><topic>Polydeoxyribonucleotides - pharmacology</topic><topic>Stimulation, Chemical</topic><topic>Verapamil - pharmacology</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Turhan, Aslihan</creatorcontrib><creatorcontrib>Piskin, Ayse Kevser</creatorcontrib><creatorcontrib>Emerk, Kaya</creatorcontrib><creatorcontrib>Imir, Turgut</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turhan, Aslihan</au><au>Piskin, Ayse Kevser</au><au>Emerk, Kaya</au><au>Imir, Turgut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Defibrotide augments the anticandidial activity of NK cells</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>28</volume><issue>5</issue><spage>733</spage><epage>735</epage><pages>733-735</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin.
2.
2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect.
3.
3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity.
4.
4. It is concluded that defibrotide is a potent activator of NK cells.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9184811</pmid><doi>10.1016/S0306-3623(96)00311-4</doi><tpages>3</tpages></addata></record> |
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| ispartof | General pharmacology, 1997-05, Vol.28 (5), p.733-735 |
| issn | 0306-3623 1879-0011 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Calcium Channel Blockers - pharmacology Candida albicans - growth & development Candida albicans - immunology Cytotoxicity, Immunologic - drug effects Fibrinolytic Agents - pharmacology Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Male Medical sciences Mice Mice, Inbred BALB C Pertussis Toxin Pharmacology. Drug treatments Polydeoxyribonucleotides - pharmacology Stimulation, Chemical Verapamil - pharmacology Virulence Factors, Bordetella - pharmacology |
| title | Defibrotide augments the anticandidial activity of NK cells |
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