[ 3H]Ro 19-6327: A reversible ligand and affinity labelling probe for monoamine oxidase-B

This study demonstrated the existence of specific binding sites [ 3H]Ro 19-6327 in human platelet membranes. This compound is a novel, time-dependent inhibitor of monoamine oxidase type B (MAO-B) and is structurally closely related to [ 3H]Ro 16-6491. The density of the sites labelled with high affi...

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Veröffentlicht in:	European journal of pharmacology 1989-03, Vol.162 (3), p.457-465
Hauptverfasser:	Cesura, Andrea M., Galva, Maria D., Imhof, René, Kyburz, Emilio, Picotti, Giovanni B., Prada, MoséDa
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity labelling Affinity Labels Benzamides - metabolism Biological and medical sciences Blood Platelets - enzymology Blood Platelets - metabolism Brain - enzymology Cell Membrane - enzymology Cell Membrane - metabolism Electrophoresis, Polyacrylamide Gel Humans In Vitro Techniques Mechanism-based reversible inhibition, High-affinity binding Medical sciences Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Monoamine oxidase-B (MAO-B) Nerve Tissue Proteins - metabolism Neuropharmacology Pharmacology. Drug treatments Picolinic Acids - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Ro 16-6491 Ro 19-6327
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