A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs
A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to in...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 1997-05, Vol.60 (23), p.PL345-PL351 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | PL351 |
|---|---|
| container_issue | 23 |
| container_start_page | PL345 |
| container_title | Life sciences (1973) |
| container_volume | 60 |
| creator | Collins, R.A. Ng, T.B. Fong, W.P. Wan, C.C. Yeung, H.W. |
| description | A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp 120 and the CD4 receptor (ID
50 5.6–79.4 μg/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID
5016.9–26.0 μg/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes. |
| doi_str_mv | 10.1016/S0024-3205(97)00227-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79068946</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320597002270</els_id><sourcerecordid>15961292</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-6730812a9989446d83272377f8f283c0d3de0d7a7b0e699a09d45c0da8c34d6e3</originalsourceid><addsrcrecordid>eNqFUctuFDEQtBAobAKfEMknBIeBtj1jj08oioAgReIAnC2P3aNtNI_FnomyNz4d70O55tRud1V1q4qxawEfBQj96SeArCsloXlvzYfSSFPBC7YRrbEVaCVess0T5DW7zPkPADSNURfswooWlBEb9u-Gh3nc-UR5nvjc8-06-onTOK7THLGnQDiFPX-gtGa-7HfIBadpSx0tVBjdnhfyQn4YymtN1BNG7v-uOBc8Pi7JhyUfhMOWJszIR4xFdPID32Lq8hv2qvdDxrfnesV-f_3y6_auuv_x7fvtzX0V6sYslTYKWiG9ta2tax1bJY1UxvRtL1sVIKqIEI03HaC21oONdVO-fRtUHTWqK_bupLtLc7kuL26kHHAY_HQ41RkLukjrZ4GisVpIKwuwOQFDmnNO2LtdotGnvRPgDhG5Y0Tu4L-zxh0jclB41-cFa1fMeGKdMynzz6c5FjseCJPLxxCKbwnD4uJMz2z4D2keoiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15961292</pqid></control><display><type>article</type><title>A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Collins, R.A. ; Ng, T.B. ; Fong, W.P. ; Wan, C.C. ; Yeung, H.W.</creator><creatorcontrib>Collins, R.A. ; Ng, T.B. ; Fong, W.P. ; Wan, C.C. ; Yeung, H.W.</creatorcontrib><description>A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp 120 and the CD4 receptor (ID
50 5.6–79.4 μg/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID
5016.9–26.0 μg/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(97)00227-0</identifier><identifier>PMID: 9180371</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>AIDS/HIV ; CD4 Antigens - drug effects ; CD4 Antigens - metabolism ; CD4-gp 120 interaction ; Chinese medicinal herbs ; Drugs, Chinese Herbal - pharmacology ; Enzyme Inhibitors - pharmacology ; glycohydrolase enzymes ; Glycoside Hydrolases - antagonists & inhibitors ; HIV Envelope Protein gp120 - drug effects ; HIV Envelope Protein gp120 - metabolism ; HIV-1 - drug effects ; HIV-1 - enzymology ; HIV-1 - physiology ; HIV-1 reverse transcriptase ; Human immunodeficiency virus 1 ; Reverse Transcriptase Inhibitors - pharmacology</subject><ispartof>Life sciences (1973), 1997-05, Vol.60 (23), p.PL345-PL351</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-6730812a9989446d83272377f8f283c0d3de0d7a7b0e699a09d45c0da8c34d6e3</citedby><cites>FETCH-LOGICAL-c457t-6730812a9989446d83272377f8f283c0d3de0d7a7b0e699a09d45c0da8c34d6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320597002270$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9180371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collins, R.A.</creatorcontrib><creatorcontrib>Ng, T.B.</creatorcontrib><creatorcontrib>Fong, W.P.</creatorcontrib><creatorcontrib>Wan, C.C.</creatorcontrib><creatorcontrib>Yeung, H.W.</creatorcontrib><title>A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp 120 and the CD4 receptor (ID
50 5.6–79.4 μg/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID
5016.9–26.0 μg/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes.</description><subject>AIDS/HIV</subject><subject>CD4 Antigens - drug effects</subject><subject>CD4 Antigens - metabolism</subject><subject>CD4-gp 120 interaction</subject><subject>Chinese medicinal herbs</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>glycohydrolase enzymes</subject><subject>Glycoside Hydrolases - antagonists & inhibitors</subject><subject>HIV Envelope Protein gp120 - drug effects</subject><subject>HIV Envelope Protein gp120 - metabolism</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - enzymology</subject><subject>HIV-1 - physiology</subject><subject>HIV-1 reverse transcriptase</subject><subject>Human immunodeficiency virus 1</subject><subject>Reverse Transcriptase Inhibitors - pharmacology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuFDEQtBAobAKfEMknBIeBtj1jj08oioAgReIAnC2P3aNtNI_FnomyNz4d70O55tRud1V1q4qxawEfBQj96SeArCsloXlvzYfSSFPBC7YRrbEVaCVess0T5DW7zPkPADSNURfswooWlBEb9u-Gh3nc-UR5nvjc8-06-onTOK7THLGnQDiFPX-gtGa-7HfIBadpSx0tVBjdnhfyQn4YymtN1BNG7v-uOBc8Pi7JhyUfhMOWJszIR4xFdPID32Lq8hv2qvdDxrfnesV-f_3y6_auuv_x7fvtzX0V6sYslTYKWiG9ta2tax1bJY1UxvRtL1sVIKqIEI03HaC21oONdVO-fRtUHTWqK_bupLtLc7kuL26kHHAY_HQ41RkLukjrZ4GisVpIKwuwOQFDmnNO2LtdotGnvRPgDhG5Y0Tu4L-zxh0jclB41-cFa1fMeGKdMynzz6c5FjseCJPLxxCKbwnD4uJMz2z4D2keoiA</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Collins, R.A.</creator><creator>Ng, T.B.</creator><creator>Fong, W.P.</creator><creator>Wan, C.C.</creator><creator>Yeung, H.W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs</title><author>Collins, R.A. ; Ng, T.B. ; Fong, W.P. ; Wan, C.C. ; Yeung, H.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-6730812a9989446d83272377f8f283c0d3de0d7a7b0e699a09d45c0da8c34d6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS/HIV</topic><topic>CD4 Antigens - drug effects</topic><topic>CD4 Antigens - metabolism</topic><topic>CD4-gp 120 interaction</topic><topic>Chinese medicinal herbs</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>glycohydrolase enzymes</topic><topic>Glycoside Hydrolases - antagonists & inhibitors</topic><topic>HIV Envelope Protein gp120 - drug effects</topic><topic>HIV Envelope Protein gp120 - metabolism</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - enzymology</topic><topic>HIV-1 - physiology</topic><topic>HIV-1 reverse transcriptase</topic><topic>Human immunodeficiency virus 1</topic><topic>Reverse Transcriptase Inhibitors - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collins, R.A.</creatorcontrib><creatorcontrib>Ng, T.B.</creatorcontrib><creatorcontrib>Fong, W.P.</creatorcontrib><creatorcontrib>Wan, C.C.</creatorcontrib><creatorcontrib>Yeung, H.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collins, R.A.</au><au>Ng, T.B.</au><au>Fong, W.P.</au><au>Wan, C.C.</au><au>Yeung, H.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>60</volume><issue>23</issue><spage>PL345</spage><epage>PL351</epage><pages>PL345-PL351</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp 120 and the CD4 receptor (ID
50 5.6–79.4 μg/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID
5016.9–26.0 μg/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9180371</pmid><doi>10.1016/S0024-3205(97)00227-0</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1997-05, Vol.60 (23), p.PL345-PL351 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79068946 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AIDS/HIV CD4 Antigens - drug effects CD4 Antigens - metabolism CD4-gp 120 interaction Chinese medicinal herbs Drugs, Chinese Herbal - pharmacology Enzyme Inhibitors - pharmacology glycohydrolase enzymes Glycoside Hydrolases - antagonists & inhibitors HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - metabolism HIV-1 - drug effects HIV-1 - enzymology HIV-1 - physiology HIV-1 reverse transcriptase Human immunodeficiency virus 1 Reverse Transcriptase Inhibitors - pharmacology |
| title | A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A53%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20comparison%20of%20human%20immunodeficiency%20virus%20type%201%20inhibition%20by%20partially%20purified%20aqueous%20extracts%20of%20chinese%20medicinal%20herbs&rft.jtitle=Life%20sciences%20(1973)&rft.au=Collins,%20R.A.&rft.date=1997-05-01&rft.volume=60&rft.issue=23&rft.spage=PL345&rft.epage=PL351&rft.pages=PL345-PL351&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/S0024-3205(97)00227-0&rft_dat=%3Cproquest_cross%3E15961292%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15961292&rft_id=info:pmid/9180371&rft_els_id=S0024320597002270&rfr_iscdi=true |