Time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage
The time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage (SAH) was studied in 24 rabbits. Animals with SAH received two successive blood injections through the cisterna magna. Horseradish peroxidase (HRP) was given intravenously 30 minutes before...
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| Veröffentlicht in: | Acta neurochirurgica 1989-01, Vol.98 (3-4), p.176-183 |
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| container_issue | 3-4 |
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| container_title | Acta neurochirurgica |
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| creator | NAKAGOMI, T KASSELL, N. F SASAKI, T LEHMAN, R. M HONGO, K OGAWA, H VOLLMER, D. G |
| description | The time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage (SAH) was studied in 24 rabbits. Animals with SAH received two successive blood injections through the cisterna magna. Horseradish peroxidase (HRP) was given intravenously 30 minutes before sacrifice to assess the integrity of the barrier. In the basilar arteries taken from animals that were sacrificed 4 days after the first SAH, HRP-reaction products were diffusely observed in the subendothelial space. Three weeks following the first SAH, permeation of HRP was still observed in half of the animals. However, in animals sacrificed 7 weeks after the first SAH, no permeation of HRP into the subendothelial space was noted. Opening of the interendothelial space seemed to be the major mechanism for HRP permeation into the subendothelial space rather than transendothelial vesicular transport. Disruption of the blood-arterial wall barrier in the major cerebral arteries following SAH may play a role in the pathogenesis of vasospasm. |
| doi_str_mv | 10.1007/BF01407345 |
| format | Article |
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F ; SASAKI, T ; LEHMAN, R. M ; HONGO, K ; OGAWA, H ; VOLLMER, D. G</creator><creatorcontrib>NAKAGOMI, T ; KASSELL, N. F ; SASAKI, T ; LEHMAN, R. M ; HONGO, K ; OGAWA, H ; VOLLMER, D. G</creatorcontrib><description>The time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage (SAH) was studied in 24 rabbits. Animals with SAH received two successive blood injections through the cisterna magna. Horseradish peroxidase (HRP) was given intravenously 30 minutes before sacrifice to assess the integrity of the barrier. In the basilar arteries taken from animals that were sacrificed 4 days after the first SAH, HRP-reaction products were diffusely observed in the subendothelial space. Three weeks following the first SAH, permeation of HRP was still observed in half of the animals. However, in animals sacrificed 7 weeks after the first SAH, no permeation of HRP into the subendothelial space was noted. Opening of the interendothelial space seemed to be the major mechanism for HRP permeation into the subendothelial space rather than transendothelial vesicular transport. Disruption of the blood-arterial wall barrier in the major cerebral arteries following SAH may play a role in the pathogenesis of vasospasm.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/BF01407345</identifier><identifier>PMID: 2741746</identifier><identifier>CODEN: ACNUA5</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Basilar Artery - pathology ; Basilar Artery - ultrastructure ; Biological and medical sciences ; Blood-Brain Barrier ; Capillary Permeability ; Disease Models, Animal ; Endothelium, Vascular - pathology ; Endothelium, Vascular - ultrastructure ; Horseradish Peroxidase - pharmacokinetics ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Rabbits ; Subarachnoid Hemorrhage - diagnostic imaging ; Subarachnoid Hemorrhage - pathology ; Subarachnoid Hemorrhage - physiopathology ; Time Factors ; Tomography, X-Ray Computed</subject><ispartof>Acta neurochirurgica, 1989-01, Vol.98 (3-4), p.176-183</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-7620e0aaf0495850c3af0af24b357470235f7b83895237cde55ce4a532994d203</citedby><cites>FETCH-LOGICAL-c311t-7620e0aaf0495850c3af0af24b357470235f7b83895237cde55ce4a532994d203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6689176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2741746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKAGOMI, T</creatorcontrib><creatorcontrib>KASSELL, N. F</creatorcontrib><creatorcontrib>SASAKI, T</creatorcontrib><creatorcontrib>LEHMAN, R. M</creatorcontrib><creatorcontrib>HONGO, K</creatorcontrib><creatorcontrib>OGAWA, H</creatorcontrib><creatorcontrib>VOLLMER, D. G</creatorcontrib><title>Time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir (Wien)</addtitle><description>The time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage (SAH) was studied in 24 rabbits. Animals with SAH received two successive blood injections through the cisterna magna. Horseradish peroxidase (HRP) was given intravenously 30 minutes before sacrifice to assess the integrity of the barrier. In the basilar arteries taken from animals that were sacrificed 4 days after the first SAH, HRP-reaction products were diffusely observed in the subendothelial space. Three weeks following the first SAH, permeation of HRP was still observed in half of the animals. However, in animals sacrificed 7 weeks after the first SAH, no permeation of HRP into the subendothelial space was noted. Opening of the interendothelial space seemed to be the major mechanism for HRP permeation into the subendothelial space rather than transendothelial vesicular transport. Disruption of the blood-arterial wall barrier in the major cerebral arteries following SAH may play a role in the pathogenesis of vasospasm.</description><subject>Animals</subject><subject>Basilar Artery - pathology</subject><subject>Basilar Artery - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Capillary Permeability</subject><subject>Disease Models, Animal</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - ultrastructure</subject><subject>Horseradish Peroxidase - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Rabbits</subject><subject>Subarachnoid Hemorrhage - diagnostic imaging</subject><subject>Subarachnoid Hemorrhage - pathology</subject><subject>Subarachnoid Hemorrhage - physiopathology</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9L30AQxZdiUau9eBf2ID0IaWd_ZZOjirYFwYuew2Qz8buyyX7dTdD-913xi17mzfA-PJjH2ImAnwLA_rq8AaHBKm2-sENotazKgL2yA4iqlnVzwL7l_FQuabXaZ_tFhNX1IfP3fiLu4poy8TjyZUO8DzEOFaaFksfAXzAE3mNKnhIffE7rdvFx5mMMIb74-ZHT67agE81LwfNaWHSbOfqBb5CmmNIGH-mYfR0xZPq-0yP2cHN9f_Wnur37_ffq4rZySoilsrUEAsQRdGsaA06VFUepe2WstiCVGW3fqKY1Ulk3kDGONBol21YPEtQR-_Geu03xeaW8dJPPjkLAmeKaO9tCbVVjCnj-DroUc040dtvyBKZ_nYDurdfus9cCn-5S136i4QPdFVn8s52P2WEYE87O5w-srptW2Fr9BzOEf-Q</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>NAKAGOMI, T</creator><creator>KASSELL, N. F</creator><creator>SASAKI, T</creator><creator>LEHMAN, R. M</creator><creator>HONGO, K</creator><creator>OGAWA, H</creator><creator>VOLLMER, D. G</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage</title><author>NAKAGOMI, T ; KASSELL, N. F ; SASAKI, T ; LEHMAN, R. M ; HONGO, K ; OGAWA, H ; VOLLMER, D. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-7620e0aaf0495850c3af0af24b357470235f7b83895237cde55ce4a532994d203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Basilar Artery - pathology</topic><topic>Basilar Artery - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Capillary Permeability</topic><topic>Disease Models, Animal</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - ultrastructure</topic><topic>Horseradish Peroxidase - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Rabbits</topic><topic>Subarachnoid Hemorrhage - diagnostic imaging</topic><topic>Subarachnoid Hemorrhage - pathology</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKAGOMI, T</creatorcontrib><creatorcontrib>KASSELL, N. F</creatorcontrib><creatorcontrib>SASAKI, T</creatorcontrib><creatorcontrib>LEHMAN, R. M</creatorcontrib><creatorcontrib>HONGO, K</creatorcontrib><creatorcontrib>OGAWA, H</creatorcontrib><creatorcontrib>VOLLMER, D. 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G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage</atitle><jtitle>Acta neurochirurgica</jtitle><addtitle>Acta Neurochir (Wien)</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>98</volume><issue>3-4</issue><spage>176</spage><epage>183</epage><pages>176-183</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><coden>ACNUA5</coden><abstract>The time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage (SAH) was studied in 24 rabbits. Animals with SAH received two successive blood injections through the cisterna magna. Horseradish peroxidase (HRP) was given intravenously 30 minutes before sacrifice to assess the integrity of the barrier. In the basilar arteries taken from animals that were sacrificed 4 days after the first SAH, HRP-reaction products were diffusely observed in the subendothelial space. Three weeks following the first SAH, permeation of HRP was still observed in half of the animals. However, in animals sacrificed 7 weeks after the first SAH, no permeation of HRP into the subendothelial space was noted. Opening of the interendothelial space seemed to be the major mechanism for HRP permeation into the subendothelial space rather than transendothelial vesicular transport. Disruption of the blood-arterial wall barrier in the major cerebral arteries following SAH may play a role in the pathogenesis of vasospasm.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>2741746</pmid><doi>10.1007/BF01407345</doi><tpages>8</tpages></addata></record> |
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| ispartof | Acta neurochirurgica, 1989-01, Vol.98 (3-4), p.176-183 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Basilar Artery - pathology Basilar Artery - ultrastructure Biological and medical sciences Blood-Brain Barrier Capillary Permeability Disease Models, Animal Endothelium, Vascular - pathology Endothelium, Vascular - ultrastructure Horseradish Peroxidase - pharmacokinetics Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Rabbits Subarachnoid Hemorrhage - diagnostic imaging Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology Time Factors Tomography, X-Ray Computed |
| title | Time course of the blood-arterial wall barrier disruption following experimental subarachnoid haemorrhage |
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