The use of streptomycin to induce unilateral ablation of vestibular function in the rat: A preliminary report

The goal of our research is to develop a method of applying streptomycin to the middle ear so as to destroy vestibular function unilaterally while avoiding damage to auditory function. In this preliminary experiment, a total of 42 mg of streptomycin was infused continuously over a seven-day period i...

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Veröffentlicht in:	American journal of otolaryngology 1989-05, Vol.10 (3), p.188-197
Hauptverfasser:	Proctor, Leonard R., El-Kashef, Yehia
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Biological and medical sciences Cochlea - drug effects Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Inner - drug effects Ear, Inner - metabolism Ear, Middle - metabolism Epithelium - drug effects Infusion Pumps Infusions, Parenteral Male Medical sciences middle ear Non tumoral diseases Otorhinolaryngology. Stomatology ototoxicity Rats Streptomycin - administration & dosage Streptomycin - pharmacokinetics vestibular ablation Vestibule, Labyrinth - drug effects
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