Dopamine/glutamate interaction as studied by combining turning behaviour and c-Fos expression

Dopamine (DA) and glutamate N-methyl- d-aspartate (NMDA) receptors extensively interact in the mediation of motor behaviours originated in basal ganglia. In unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats, this interaction is of a different sign depending on whether D 1 or D 2 receptors are st...

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Veröffentlicht in:	Neuroscience and biobehavioral reviews 1997, Vol.21 (4), p.505-509
1. Verfasser:	Morelli, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basal ganglia c-Fos D 1-receptor dopamine Dopamine - physiology Dopamine Agonists - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Gene Expression - drug effects Gene Expression - physiology Genes, fos - physiology glutamate Glutamic Acid - physiology NMDA Parkinson Rats sensitization Stereotyped Behavior - drug effects Stereotyped Behavior - physiology
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description	Dopamine (DA) and glutamate N-methyl- d-aspartate (NMDA) receptors extensively interact in the mediation of motor behaviours originated in basal ganglia. In unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats, this interaction is of a different sign depending on whether D 1 or D 2 receptors are stimulated. Contralateral turning behaviour induced by D 1 agonists is potentiated by the NMDA antagonist MK 801, while turning behaviour induced by D 2 agonists is decreased. NMDA receptors not only modulate the acute turning behaviour induced by DA agonists but also the long-term effects induced by stimulation of DA receptors. MK 801, in fact, prevents the sensitization (priming) of D 1-mediated turning behaviour induced by a single exposure to a DA agonist. Prevention of priming by MK 801, also appears to be different depending on whether D 1 or D 1 D 2 receptors are stimulated. Studies on c-fos expression induced by DA D 1 agonists in the 6-OHDA lesioned striatum show that detection of Fos-like immunoreactivity correlates to the long-term but not the acute effects induced by DA receptor stimulation and NMDA receptor blockade.
doi_str_mv	10.1016/S0149-7634(96)00031-0
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Studies on c-fos expression induced by DA D 1 agonists in the 6-OHDA lesioned striatum show that detection of Fos-like immunoreactivity correlates to the long-term but not the acute effects induced by DA receptor stimulation and NMDA receptor blockade.</description><subject>Animals</subject><subject>basal ganglia</subject><subject>c-Fos</subject><subject>D 1-receptor</subject><subject>dopamine</subject><subject>Dopamine - physiology</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Excitatory Amino Acid Agonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - physiology</subject><subject>Genes, fos - physiology</subject><subject>glutamate</subject><subject>Glutamic Acid - physiology</subject><subject>NMDA</subject><subject>Parkinson</subject><subject>Rats</subject><subject>sensitization</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Stereotyped Behavior - physiology</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOj5-wkBWootqMkmTZiWijgqCC3UpIU1ux8i0GZNUnH9v54FbV2dxvnMvfAiNKbmghIrLF0K5KqRg_EyJc0IIowXZQSNaSVbIclLtotEfcoAOU_ocoAlh5T7aV1SVgqgRer8NC9P6Di5n8z6b1mTAvssQjc0-dNgknHLvPDhcL7ENbe07381w7uM6a_gw3z70EZvOYVtMQ8Lws4iQ0jA_RnuNmSc42eYRepvevd48FE_P948310-FZYrmwtRVbWmtLOXW8QqY5JUAC7XiTWNlaUrpFOeilHzCiOKVa6SVVAorG8U4Z0fodHN3EcNXDynr1icL87npIPRJS0WEkJL-C1LBmVJ0BZYb0MaQUoRGL6JvTVxqSvTKv1771yu5Wgm99q_JsBtvH_R1C-5vtRU-9FebHgYd3x6iTtZDZ8H5CDZrF_w_H34BXn6Vwg</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Morelli, M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Dopamine/glutamate interaction as studied by combining turning behaviour and c-Fos expression</title><author>Morelli, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-ab8bc1b9c14cd48e37486eceb94ffc75a57d9446574230948df7c7176c7f93443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>basal ganglia</topic><topic>c-Fos</topic><topic>D 1-receptor</topic><topic>dopamine</topic><topic>Dopamine - physiology</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Excitatory Amino Acid Agonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - physiology</topic><topic>Genes, fos - physiology</topic><topic>glutamate</topic><topic>Glutamic Acid - physiology</topic><topic>NMDA</topic><topic>Parkinson</topic><topic>Rats</topic><topic>sensitization</topic><topic>Stereotyped Behavior - drug effects</topic><topic>Stereotyped Behavior - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morelli, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morelli, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine/glutamate interaction as studied by combining turning behaviour and c-Fos expression</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>1997</date><risdate>1997</risdate><volume>21</volume><issue>4</issue><spage>505</spage><epage>509</epage><pages>505-509</pages><issn>0149-7634</issn><eissn>1873-7528</eissn><abstract>Dopamine (DA) and glutamate N-methyl- d-aspartate (NMDA) receptors extensively interact in the mediation of motor behaviours originated in basal ganglia. In unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats, this interaction is of a different sign depending on whether D 1 or D 2 receptors are stimulated. Contralateral turning behaviour induced by D 1 agonists is potentiated by the NMDA antagonist MK 801, while turning behaviour induced by D 2 agonists is decreased. NMDA receptors not only modulate the acute turning behaviour induced by DA agonists but also the long-term effects induced by stimulation of DA receptors. MK 801, in fact, prevents the sensitization (priming) of D 1-mediated turning behaviour induced by a single exposure to a DA agonist. Prevention of priming by MK 801, also appears to be different depending on whether D 1 or D 1 D 2 receptors are stimulated. Studies on c-fos expression induced by DA D 1 agonists in the 6-OHDA lesioned striatum show that detection of Fos-like immunoreactivity correlates to the long-term but not the acute effects induced by DA receptor stimulation and NMDA receptor blockade.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>9195609</pmid><doi>10.1016/S0149-7634(96)00031-0</doi><tpages>5</tpages></addata></record>
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subjects	Animals basal ganglia c-Fos D 1-receptor dopamine Dopamine - physiology Dopamine Agonists - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Gene Expression - drug effects Gene Expression - physiology Genes, fos - physiology glutamate Glutamic Acid - physiology NMDA Parkinson Rats sensitization Stereotyped Behavior - drug effects Stereotyped Behavior - physiology
title	Dopamine/glutamate interaction as studied by combining turning behaviour and c-Fos expression
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