Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes

Dopamine transporters (DATs) are members of a family of Na+- and Cl−-dependent neurotransmitter transporters responsible for the rapid clearance of dopamine from synaptic clefts. The predicted primary sequence of DAT contains numerous consensus phosphorylation sites. In this report we demonstrate th...

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Veröffentlicht in:	The Journal of biological chemistry 1997-06, Vol.272 (24), p.15541-15546
Hauptverfasser:	Vaughan, Roxanne A., Huff, Robin A., Uhl, George R., Kuhar, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Corpus Striatum - enzymology Corpus Striatum - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Kinetics Male Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Phosphorylation Protein Kinase C - metabolism Rats Rats, Sprague-Dawley Synaptosomes - enzymology Synaptosomes - metabolism
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