Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages

Components of Trypanosoma cruzi able to induce the production of IL-12 and other proinflammatory cytokines by macrophages were identified. Murine inflammatory macrophages were cultured with live parasites or with cellular components from different developmental forms of T. cruzi (i.e., trypomastigot...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-06, Vol.158 (12), p.5890-5901
Hauptverfasser:	Camargo, MM, Almeida, IC, Pereira, ME, Ferguson, MA, Travassos, LR, Gazzinelli, RT
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Glycoproteins - chemistry Glycoproteins - immunology Glycosylphosphatidylinositols - immunology Glycosylphosphatidylinositols - isolation & purification Interferon-gamma - pharmacology Interleukin-12 - biosynthesis Macrophages - immunology Mice Mice, Inbred C3H Mice, SCID Mucins - chemistry Mucins - immunology Trypanosoma cruzi Trypanosoma cruzi - chemistry Trypanosoma cruzi - immunology
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