Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity
Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24 recorded neurons were activated during motor behavior such as locomotion ( n = 11) or head movements ( n = 4). The behavioral response to amphetamine (1.0 mg/kg) was associated with increases ( n = 17) or...
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| Veröffentlicht in: | Brain research 1989-06, Vol.489 (2), p.365-368 |
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| container_title | Brain research |
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| creator | Haracz, John L. Tschanz, JoAnn T. Greenberg, Jordan Rebec, George V. |
| description | Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24 recorded neurons were activated during motor behavior such as locomotion (
n = 11) or head movements (
n = 4). The behavioral response to amphetamine (1.0 mg/kg) was associated with increases (
n = 17) or decreases (
n = 7) in firing rate. A significantly greater proportion of motor-related neurons were excited by the drug compared to nonmotor-related cells. These results, which confirm the heterogeneity of amphetamine-induced effects in the neostriatum, indicate that the baseline motor-response characteristics of neostriatal neurons may determine their response to amphetamine. |
| doi_str_mv | 10.1016/0006-8993(89)90872-X |
| format | Article |
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n = 11) or head movements (
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n = 17) or decreases (
n = 7) in firing rate. A significantly greater proportion of motor-related neurons were excited by the drug compared to nonmotor-related cells. These results, which confirm the heterogeneity of amphetamine-induced effects in the neostriatum, indicate that the baseline motor-response characteristics of neostriatal neurons may determine their response to amphetamine.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90872-X</identifier><identifier>PMID: 2743163</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Action Potentials - drug effects ; Amphetamine ; Amphetamines - pharmacology ; Animals ; Biological and medical sciences ; Corpus Striatum - drug effects ; Corpus Striatum - physiology ; Freely moving rat ; Male ; Medical sciences ; Motor Activity - drug effects ; Neostriatum ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Single-unit activity</subject><ispartof>Brain research, 1989-06, Vol.489 (2), p.365-368</ispartof><rights>1989 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-24df87a45d03887371ea71740959389d94c2952b0d71c376cb135927e80fc04b3</citedby><cites>FETCH-LOGICAL-c418t-24df87a45d03887371ea71740959389d94c2952b0d71c376cb135927e80fc04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(89)90872-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19299481$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2743163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haracz, John L.</creatorcontrib><creatorcontrib>Tschanz, JoAnn T.</creatorcontrib><creatorcontrib>Greenberg, Jordan</creatorcontrib><creatorcontrib>Rebec, George V.</creatorcontrib><title>Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24 recorded neurons were activated during motor behavior such as locomotion (
n = 11) or head movements (
n = 4). The behavioral response to amphetamine (1.0 mg/kg) was associated with increases (
n = 17) or decreases (
n = 7) in firing rate. A significantly greater proportion of motor-related neurons were excited by the drug compared to nonmotor-related cells. These results, which confirm the heterogeneity of amphetamine-induced effects in the neostriatum, indicate that the baseline motor-response characteristics of neostriatal neurons may determine their response to amphetamine.</description><subject>Action Potentials - drug effects</subject><subject>Amphetamine</subject><subject>Amphetamines - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - physiology</subject><subject>Freely moving rat</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Neostriatum</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Single-unit activity</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhG4CUCxUcAv6X2HNBqiqgSJW4gNSb5bUnrFESL7ZT2m-Pw67KrVzsGb3fPI3eEPKS0XeMsv49pbRvNYB4o-EtUK14e_2IbNha9FzSx2Rzjzwlz3L-WVshgJ6QE66kYL3YkN35tN9hsVOYsQ2zXxz6Bm9dKLaEOOdmn9DHqtqCTZibHOYfIzYzxlxSsMWOtV7SSuZd_F3VZoolpjbhWEd8Y10JN6HcPSdPBjtmfHH8T8n3Tx-_XVy2V18_f7k4v2qdZLq0XPpBKys7T4XWSiiGVjElKXQgNHiQjkPHt9Qr5oTq3ZaJDrhCTQdH5VackrOD7z7FXwvmYqaQHY6jrTsv2SigPRei_y_IOsEpwArKA-hSzDnhYPYpTDbdGUbNegmzxmzWmOtj_l7CXNexV0f_ZTuhvx86Rl_110fdZmfHIdnZhfzPGziA1KxyHw4c1tRuAiaTXcC53ikkdMX4GB5e5A_rO6Ym</recordid><startdate>19890612</startdate><enddate>19890612</enddate><creator>Haracz, John L.</creator><creator>Tschanz, JoAnn T.</creator><creator>Greenberg, Jordan</creator><creator>Rebec, George V.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890612</creationdate><title>Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity</title><author>Haracz, John L. ; Tschanz, JoAnn T. ; Greenberg, Jordan ; Rebec, George V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-24df87a45d03887371ea71740959389d94c2952b0d71c376cb135927e80fc04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Action Potentials - drug effects</topic><topic>Amphetamine</topic><topic>Amphetamines - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - physiology</topic><topic>Freely moving rat</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Neostriatum</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Single-unit activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haracz, John L.</creatorcontrib><creatorcontrib>Tschanz, JoAnn T.</creatorcontrib><creatorcontrib>Greenberg, Jordan</creatorcontrib><creatorcontrib>Rebec, George V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haracz, John L.</au><au>Tschanz, JoAnn T.</au><au>Greenberg, Jordan</au><au>Rebec, George V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-06-12</date><risdate>1989</risdate><volume>489</volume><issue>2</issue><spage>365</spage><epage>368</epage><pages>365-368</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24 recorded neurons were activated during motor behavior such as locomotion (
n = 11) or head movements (
n = 4). The behavioral response to amphetamine (1.0 mg/kg) was associated with increases (
n = 17) or decreases (
n = 7) in firing rate. A significantly greater proportion of motor-related neurons were excited by the drug compared to nonmotor-related cells. These results, which confirm the heterogeneity of amphetamine-induced effects in the neostriatum, indicate that the baseline motor-response characteristics of neostriatal neurons may determine their response to amphetamine.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2743163</pmid><doi>10.1016/0006-8993(89)90872-X</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1989-06, Vol.489 (2), p.365-368 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Action Potentials - drug effects Amphetamine Amphetamines - pharmacology Animals Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - physiology Freely moving rat Male Medical sciences Motor Activity - drug effects Neostriatum Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Single-unit activity |
| title | Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity |
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