Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients
Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone m...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-06, Vol.276 (5320), p.1851-1854 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Rettig, M. B. Ma, H. J. Vescio, R. A. Põld, M. Schiller, G. Belson, D. Savage, A. Nishikubo, C. Wu, C. Fraser, J. Said, J. W. Berenson, J. R. |
| description | Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells. |
| doi_str_mv | 10.1126/science.276.5320.1851 |
| format | Article |
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B. ; Ma, H. J. ; Vescio, R. A. ; Põld, M. ; Schiller, G. ; Belson, D. ; Savage, A. ; Nishikubo, C. ; Wu, C. ; Fraser, J. ; Said, J. W. ; Berenson, J. R.</creator><creatorcontrib>Rettig, M. B. ; Ma, H. J. ; Vescio, R. A. ; Põld, M. ; Schiller, G. ; Belson, D. ; Savage, A. ; Nishikubo, C. ; Wu, C. ; Fraser, J. ; Said, J. W. ; Berenson, J. R.</creatorcontrib><description>Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. 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B.</creatorcontrib><creatorcontrib>Ma, H. J.</creatorcontrib><creatorcontrib>Vescio, R. A.</creatorcontrib><creatorcontrib>Põld, M.</creatorcontrib><creatorcontrib>Schiller, G.</creatorcontrib><creatorcontrib>Belson, D.</creatorcontrib><creatorcontrib>Savage, A.</creatorcontrib><creatorcontrib>Nishikubo, C.</creatorcontrib><creatorcontrib>Wu, C.</creatorcontrib><creatorcontrib>Fraser, J.</creatorcontrib><creatorcontrib>Said, J. W.</creatorcontrib><creatorcontrib>Berenson, J. R.</creatorcontrib><title>Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. 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KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Bone Marrow - virology</subject><subject>Bone marrow cells</subject><subject>Cancer</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Causes of</subject><subject>Cell lines</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cellular biology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - virology</subject><subject>DNA, Viral - analysis</subject><subject>Herpes viruses</subject><subject>herpesvirus</subject><subject>Herpesvirus 8, Human - genetics</subject><subject>Herpesvirus 8, Human - isolation & purification</subject><subject>Herpesvirus 8, Human - pathogenicity</subject><subject>Herpesvirus 8, Human - physiology</subject><subject>Herpesviruses</subject><subject>HL-60 Cells</subject><subject>Human herpesvirus 8</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Interleukin-6 - analysis</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - physiology</subject><subject>Kaposi's sarcoma</subject><subject>Kaposi's sarcoma-associated herpesvirus</subject><subject>Kaposis sarcoma</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Memoranda of understanding</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - pathology</subject><subject>Multiple Myeloma - virology</subject><subject>Paraproteinemias - pathology</subject><subject>Paraproteinemias - virology</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Plasma cells</subject><subject>Polymerase Chain Reaction</subject><subject>Stromal cells</subject><subject>Stromal Cells - pathology</subject><subject>Stromal Cells - virology</subject><subject>Tumors</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN011v0zAUBuAIgcYY_AMmRWhiXCzFH3ViX3YFuoqOIg24tRznpHKVxMV2gP17HLUaKqqg8kUkn8dHduw3Sc4xGmFM8rdeG-g0jEiRjxglcZYz_Cg5xUiwTBBEHyenCNE846hgT5Nn3q8RijVBT5ITgTlnRJwm9qPaWG8ufXqnnLatyibeW21UgCq9AbcB_8O43qfzrgYdjO1SW6fXtoP0Vjlnf6bvoKucCUanU2gan9bOtult3wSzaSK6hyZ2TT-rELcb_PPkSa0aDy9237Pk64f3X6Y32WI5m08ni0wXnIWspErUSuiyHOe8qksUT4VyggjXCpWgK6GLQpW81IiiUsB4DKLUuNR1NQZeU3qWvN723Tj7vQcfZGu8jhtUHdjeyyK2Q4wN8PLfcEwHKNh_W2ImckJYEeGrv-Da9q6Lx5UEU1ZggVFEV1u0Ug1I09U2OKVX0IFTTfy9tYnTEywYR0IMPDvA46igNfqQf7PnIwnwK6xU772c3306mi6_HU2vZ8dSPlvs0atDVNumgRXI-C6myz3Otlw7672DWm6caZW7lxjJIRpyFw0ZoyGHaMghGnHd-e5a-rKF6mHVLguxfrGrK69VUzvVaeMfGCkIwsVwuy-3bO2DdX_KXNAxzulvZQceKA</recordid><startdate>19970620</startdate><enddate>19970620</enddate><creator>Rettig, M. 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B.</au><au>Ma, H. J.</au><au>Vescio, R. A.</au><au>Põld, M.</au><au>Schiller, G.</au><au>Belson, D.</au><au>Savage, A.</au><au>Nishikubo, C.</au><au>Wu, C.</au><au>Fraser, J.</au><au>Said, J. W.</au><au>Berenson, J. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1997-06-20</date><risdate>1997</risdate><volume>276</volume><issue>5320</issue><spage>1851</spage><epage>1854</epage><pages>1851-1854</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9188529</pmid><doi>10.1126/science.276.5320.1851</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-06, Vol.276 (5320), p.1851-1854 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79060553 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | AIDS/HIV Biological and medical sciences Blotting, Southern Bone marrow Bone Marrow - pathology Bone Marrow - virology Bone marrow cells Cancer Carcinogenesis, carcinogens and anticarcinogens Causes of Cell lines Cell Transformation, Neoplastic Cellular biology Dendritic cells Dendritic Cells - virology DNA, Viral - analysis Herpes viruses herpesvirus Herpesvirus 8, Human - genetics Herpesvirus 8, Human - isolation & purification Herpesvirus 8, Human - pathogenicity Herpesvirus 8, Human - physiology Herpesviruses HL-60 Cells Human herpesvirus 8 Humans In Situ Hybridization Interleukin-6 - analysis Interleukin-6 - genetics Interleukin-6 - physiology Kaposi's sarcoma Kaposi's sarcoma-associated herpesvirus Kaposis sarcoma Medical research Medical sciences Memoranda of understanding Multiple myeloma Multiple Myeloma - pathology Multiple Myeloma - virology Paraproteinemias - pathology Paraproteinemias - virology Patients Physiological aspects Plasma cells Polymerase Chain Reaction Stromal cells Stromal Cells - pathology Stromal Cells - virology Tumors Viruses |
| title | Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A37%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Kaposi's%20Sarcoma-Associated%20Herpesvirus%20Infection%20of%20Bone%20Marrow%20Dendritic%20Cells%20from%20Multiple%20Myeloma%20Patients&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Rettig,%20M.%20B.&rft.date=1997-06-20&rft.volume=276&rft.issue=5320&rft.spage=1851&rft.epage=1854&rft.pages=1851-1854&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.276.5320.1851&rft_dat=%3Cgale_proqu%3EA19580990%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213571910&rft_id=info:pmid/9188529&rft_galeid=A19580990&rft_jstor_id=2893416&rfr_iscdi=true |