Etiology of otospongiotic sensorineural losses

The etiology of otospongiotic-otosclerotic disease is enzymatic; the proteolytic enzymes released by the otospongiotic-otosclerotic foci damage the inner ear and are also the basis of the bony rebuilding of the OW niche leading to stapedial fixation. The trigger may be an autoimmune process due to t...

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Veröffentlicht in:The American journal of otology (New York, N.Y.) N.Y.), 1989-03, Vol.10 (2), p.99-107
Hauptverfasser: CAUSSE, J. R, CAUSSE, J. B, BRETLAU, P, URIEL, J, BERGES, J, CHEVANCE, L. G, SHAMBAUGH, G. E, BASTIDE, J. M
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container_title The American journal of otology (New York, N.Y.)
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creator CAUSSE, J. R
CAUSSE, J. B
BRETLAU, P
URIEL, J
BERGES, J
CHEVANCE, L. G
SHAMBAUGH, G. E
BASTIDE, J. M
description The etiology of otospongiotic-otosclerotic disease is enzymatic; the proteolytic enzymes released by the otospongiotic-otosclerotic foci damage the inner ear and are also the basis of the bony rebuilding of the OW niche leading to stapedial fixation. The trigger may be an autoimmune process due to the reaction of the enchondral otic capsule against the embryonic cartilaginous remnants, genetically determined to be located in the otic capsule and mainly in the fissula antefenestram.
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ispartof The American journal of otology (New York, N.Y.), 1989-03, Vol.10 (2), p.99-107
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source MEDLINE; Journals@Ovid Complete
subjects Antibody Formation
Autoantibodies - physiology
Biological and medical sciences
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Hearing Loss, Sensorineural - etiology
Histiocytes - physiology
Humans
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Otosclerosis - enzymology
Otosclerosis - immunology
Otosclerosis - physiopathology
Peptide Hydrolases - physiology
title Etiology of otospongiotic sensorineural losses
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