DNA fragmentation is a feature of cystic fibrosis epithelial cells: a disease with inappropriate apoptosis?

Cystic fibrosis (CF) is a single-gene disease caused by mutations in the CFTR gene, which result in disrupted chloride secretions with inspissated mucous secretions by exocrine glands. Nick-end labelling was used to assess DNA fragmentation in 14 CF and 24 control duodenal samples, and in two CF and...

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Veröffentlicht in:	FEBS letters 1997-05, Vol.408 (2), p.225-231
Hauptverfasser:	Maiuri, Luigi, Raia, Valeria, De Marco, Giulio, Coletta, Salvatore, de Ritis, Giorgio, Londei, Marco, Auricchio, Salvatore
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Apoptosis Bronchi - cytology Bronchi - metabolism CFTR Child Child, Preschool Culture Techniques Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - pathology Cystic fibrosis transmembrane conductance regulator Digoxigenin - metabolism DNA Fragmentation DNA Nucleotidylexotransferase - metabolism Duodenum - metabolism Duodenum - pathology Epithelium - metabolism Epithelium - pathology Female Gastric Mucosa - metabolism Gastric Mucosa - pathology Humans Immunohistochemistry Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lung - metabolism Lung - pathology Male PCD Programmed cell death terminal deoxynucleotidyl transferase-mediated d-UTP-digoxygenin nick-end labelling TUNEL
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