Reversibility of Upper Airway Obstruction after Levodopa Therapy in Parkinson's Disease
Serial flow-volume loops obtained in a 66-year-old patient with Parkinson's disease and recurrent episodes of dyspnea revealed a pattern consistent with upper airway obstruction, reversible after oral intake of levodopa. This observation shows that extrapyramidal involvement of the striated upp...
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| Veröffentlicht in: | Chest 1989-07, Vol.96 (1), p.210-212 |
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| creator | Vincken, Walter G. Darauay, Carmen M. Cosio, Manuel G. |
| description | Serial flow-volume loops obtained in a 66-year-old patient with Parkinson's disease and recurrent episodes of dyspnea revealed a pattern consistent with upper airway obstruction, reversible after oral intake of levodopa. This observation shows that extrapyramidal involvement of the striated upper airway musculature may limit airflow and cause respiratory symptoms. Persistence of flow oscillations on the flow-volume loop contour after reversal of upper airway obstruction and dyspnea should be considered to reflect upper airway dysfunction with possibly serious consequences. |
| doi_str_mv | 10.1378/chest.96.1.210 |
| format | Article |
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This observation shows that extrapyramidal involvement of the striated upper airway musculature may limit airflow and cause respiratory symptoms. Persistence of flow oscillations on the flow-volume loop contour after reversal of upper airway obstruction and dyspnea should be considered to reflect upper airway dysfunction with possibly serious consequences.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.96.1.210</identifier><identifier>PMID: 2736982</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Dyspnea - etiology ; Dyspnea - prevention & control ; Humans ; Levodopa - therapeutic use ; Male ; Medical sciences ; Neuropharmacology ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Pharmacology. 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This observation shows that extrapyramidal involvement of the striated upper airway musculature may limit airflow and cause respiratory symptoms. Persistence of flow oscillations on the flow-volume loop contour after reversal of upper airway obstruction and dyspnea should be considered to reflect upper airway dysfunction with possibly serious consequences.</description><subject>Aged</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Dyspnea - etiology</subject><subject>Dyspnea - prevention & control</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Ventilation</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtv1DAUhS0EKkNhyw7JCwSrBD8msb2sWl7SSEWoFUvLca4Zl0wcfJOp5t9jmFFhw8qyzzn3XH-EvOSs5lLpd34LONemrXktOHtEVtxIXslmLR-TFWNcVLI14il5hnjHyp2b9oycCVVetViRb19hDxljF4c4H2gK9HaaINOLmO_dgV53OOfFzzGN1IW5CBvYpz5Njt5sIbvpQONIv7j8I46YxrdIryKCQ3hOngQ3ILw4nefk9sP7m8tP1eb64-fLi03lGybmqnWgjA5CNUEI3_aeNYIZ1q-ZUMBbzYFrt-6bjrfCKNUF41jThV55sZblD_KcvDnOnXL6uRQUdhfRwzC4EdKCVhnWaC10MdZHo88JMUOwU447lw-WM_ubpP1D0prWcltIlsCr0-Sl20H_YD-hK_rrk-7QuyFkN_qIDzYlhTRG_u3dxu_b-5jB4s4NQxkqj413acmjG_7p1ccAFGz7CNmijzB66EvYz7ZP8X8r_wJsQKCS</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Vincken, Walter G.</creator><creator>Darauay, Carmen M.</creator><creator>Cosio, Manuel G.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Reversibility of Upper Airway Obstruction after Levodopa Therapy in Parkinson's Disease</title><author>Vincken, Walter G. ; Darauay, Carmen M. ; Cosio, Manuel G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-6ae798f275f22c6dc052090d4027e1681e18a4d5b162977bf9a05bfd7c2437363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Dyspnea - etiology</topic><topic>Dyspnea - prevention & control</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincken, Walter G.</creatorcontrib><creatorcontrib>Darauay, Carmen M.</creatorcontrib><creatorcontrib>Cosio, Manuel G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincken, Walter G.</au><au>Darauay, Carmen M.</au><au>Cosio, Manuel G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversibility of Upper Airway Obstruction after Levodopa Therapy in Parkinson's Disease</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>96</volume><issue>1</issue><spage>210</spage><epage>212</epage><pages>210-212</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Serial flow-volume loops obtained in a 66-year-old patient with Parkinson's disease and recurrent episodes of dyspnea revealed a pattern consistent with upper airway obstruction, reversible after oral intake of levodopa. This observation shows that extrapyramidal involvement of the striated upper airway musculature may limit airflow and cause respiratory symptoms. Persistence of flow oscillations on the flow-volume loop contour after reversal of upper airway obstruction and dyspnea should be considered to reflect upper airway dysfunction with possibly serious consequences.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>2736982</pmid><doi>10.1378/chest.96.1.210</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Chest, 1989-07, Vol.96 (1), p.210-212 |
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| subjects | Aged Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Dyspnea - etiology Dyspnea - prevention & control Humans Levodopa - therapeutic use Male Medical sciences Neuropharmacology Parkinson Disease - complications Parkinson Disease - drug therapy Pharmacology. Drug treatments Pulmonary Ventilation |
| title | Reversibility of Upper Airway Obstruction after Levodopa Therapy in Parkinson's Disease |
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