Salivary passage of 5-fluorouracil during continuous infusion

Plasmatic and salivary concentrations of 5-FU were investigated in ten patients given 5-day continuous infusions of 5-fluorouracil (5-FU) (1 g/m2/day). Measurable concentrations of salivary 5-FU were scattered ranging from 6 to 100 ng/ml. Between individual 5-FU concentrations in saliva and plasma t...

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Veröffentlicht in:Cancer chemotherapy and pharmacology 1989-01, Vol.24 (3), p.197-199
Hauptverfasser: MILANO, G, THYSS, A, SANTINI, J, FRENEY, M, FRANCOIS, E, SCHNEIDER, M, DEMARD, F
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container_end_page 199
container_issue 3
container_start_page 197
container_title Cancer chemotherapy and pharmacology
container_volume 24
creator MILANO, G
THYSS, A
SANTINI, J
FRENEY, M
FRANCOIS, E
SCHNEIDER, M
DEMARD, F
description Plasmatic and salivary concentrations of 5-FU were investigated in ten patients given 5-day continuous infusions of 5-fluorouracil (5-FU) (1 g/m2/day). Measurable concentrations of salivary 5-FU were scattered ranging from 6 to 100 ng/ml. Between individual 5-FU concentrations in saliva and plasma the coefficient of correlation was low. The theoretically predicted ratios of 5-FU concentrations in saliva over those in plasma, calculated as a function of salivary pH, did not correlate with the observed ratios, the majority of which ranged between 0.1 and 0.5. Noteworthy, 8 of 10 patients exhibited a more or less pronounced increase in 5-FU salivary excretion during 5-day continuous i.v. infusions.
doi_str_mv 10.1007/BF00300243
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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Aged
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Chromatography, High Pressure Liquid
Fluorouracil - administration & dosage
Fluorouracil - analysis
Fluorouracil - pharmacokinetics
Humans
Hydrogen-Ion Concentration
Infusions, Intravenous
Medical sciences
Middle Aged
Neoplasms - drug therapy
Neoplasms - metabolism
Pharmacology. Drug treatments
Saliva - analysis
Saliva - metabolism
Time Factors
title Salivary passage of 5-fluorouracil during continuous infusion
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