Automatic correction of the interfering effect of unsuppressed interspersed repetitive sequences in comparative genomic hybridization analysis
Comparative genomic hybridization (CGH) is a relatively new technique whose application is increasing. The method has mostly been employed for detection of chromosome aberrations in cancers, and a large amount of data in this field is accumulating. At the same time, efforts are made to improve the t...
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| Veröffentlicht in: | Cytometry (New York, N.Y.) N.Y.), 1997-06, Vol.28 (2), p.130-134 |
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| container_title | Cytometry (New York, N.Y.) |
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| creator | Kirchhoff, Maria Gerdes, Tommy Maahr, Jan Rose, Hanne Lundsteen, Claes |
| description | Comparative genomic hybridization (CGH) is a relatively new technique whose application is increasing. The method has mostly been employed for detection of chromosome aberrations in cancers, and a large amount of data in this field is accumulating. At the same time, efforts are made to improve the technique in order to increase the sensitivity and the generation of reliable results. Based on experimental data, we have developed a computer algorithm for eliminating some of the interfering effects of unsuppressed repetitive sequences in CGH analysis, and thereby improved our CGH analysis system. Cytometry 28:130–134, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0320(19970601)28:2<130::AID-CYTO5>3.0.CO;2-J |
| format | Article |
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| identifier | ISSN: 0196-4763 |
| ispartof | Cytometry (New York, N.Y.), 1997-06, Vol.28 (2), p.130-134 |
| issn | 0196-4763 1097-0320 |
| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Algorithms CGH Chromosome Aberrations Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 21 comparative genomic hybridization Cot1 DNA DNA - analysis Female Humans Image Processing, Computer-Assisted In Situ Hybridization, Fluorescence - methods quantitative image analysis repetitive sequences Repetitive Sequences, Nucleic Acid X Chromosome |
| title | Automatic correction of the interfering effect of unsuppressed interspersed repetitive sequences in comparative genomic hybridization analysis |
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