Changes in hypothalamic oxytocin levels during morphine tolerance
The role of hypothalamic oxytocin neurons in the hypothalamus—pituitary—adrenal (HPA) axis adaptation during opioid tolerance has not been explored. In this study the modification of oxytocin levels in different hypothalamic nuclei was determined after acute or chronic morphine exposure. Male rats w...
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| Veröffentlicht in: | Neuropeptides (Edinburgh) 1997-04, Vol.31 (2), p.143-146 |
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| creator | Laorden, M.L Milanés, M.V Chapleur-Château, M Burlet, A |
| description | The role of hypothalamic oxytocin neurons in the hypothalamus—pituitary—adrenal (HPA) axis adaptation during opioid tolerance has not been explored. In this study the modification of oxytocin levels in different hypothalamic nuclei was determined after acute or chronic morphine exposure. Male rats were implanted with placebo (naïve) or morphine (tolerant) pellets for 7 days. On day 8, groups of rats received an acute injection of either saline i.p. or morphine (30 mg/kg i.p.) and were sacrificed 30 min later. In morphine-tolerant rats, there was a decrease in the oxytocin content in the median eminence (ME) and in the supraoptic nucleus (SO) after acute injection of saline or morphine. No modifications were seen in the paraventricular nucleus (PVN). The present study demonstrates that chronic morphine administration alters the brain oxytocin system, which suggests that this peptide might contribute to the behavioural, emotional and neuroendocrine responses to opioids. |
| doi_str_mv | 10.1016/S0143-4179(97)90083-4 |
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In this study the modification of oxytocin levels in different hypothalamic nuclei was determined after acute or chronic morphine exposure. Male rats were implanted with placebo (naïve) or morphine (tolerant) pellets for 7 days. On day 8, groups of rats received an acute injection of either saline i.p. or morphine (30 mg/kg i.p.) and were sacrificed 30 min later. In morphine-tolerant rats, there was a decrease in the oxytocin content in the median eminence (ME) and in the supraoptic nucleus (SO) after acute injection of saline or morphine. No modifications were seen in the paraventricular nucleus (PVN). 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Urophysis ; Kinetics ; Male ; Median Eminence - metabolism ; Morphine - pharmacology ; Oxytocin - metabolism ; Paraventricular Hypothalamic Nucleus - metabolism ; Rats ; Rats, Sprague-Dawley ; Reference Values ; Supraoptic Nucleus - metabolism ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>Neuropeptides (Edinburgh), 1997-04, Vol.31 (2), p.143-146</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-3649441d6a5f00349ef6c896ea50574954ee5d09c239d70dec4d28a4d83a1bd73</citedby><cites>FETCH-LOGICAL-c420t-3649441d6a5f00349ef6c896ea50574954ee5d09c239d70dec4d28a4d83a1bd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0143-4179(97)90083-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2659413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9179867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laorden, M.L</creatorcontrib><creatorcontrib>Milanés, M.V</creatorcontrib><creatorcontrib>Chapleur-Château, M</creatorcontrib><creatorcontrib>Burlet, A</creatorcontrib><title>Changes in hypothalamic oxytocin levels during morphine tolerance</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>The role of hypothalamic oxytocin neurons in the hypothalamus—pituitary—adrenal (HPA) axis adaptation during opioid tolerance has not been explored. 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The present study demonstrates that chronic morphine administration alters the brain oxytocin system, which suggests that this peptide might contribute to the behavioural, emotional and neuroendocrine responses to opioids.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Kinetics</subject><subject>Male</subject><subject>Median Eminence - metabolism</subject><subject>Morphine - pharmacology</subject><subject>Oxytocin - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reference Values</subject><subject>Supraoptic Nucleus - metabolism</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMoWqs_QdiDiB5Wk837JKX4goIH9RxiMmsju5uabMX-e7e29OppmJlvHnwInRF8TTARNy-YMFoyIvWlllcaYzVke2hEOK3KSiq-j0Y75Agd5_yJMWaVUofoUA81JeQITaZz231ALkJXzFeL2M9tY9vgiviz6qMbqg18Q5MLv0yh-yjamBbz0EHRxwaS7RycoIPaNhlOt3GM3u7vXqeP5ez54Wk6mZWOVbgvqWCaMeKF5TXGlGmohVNagOWYS6Y5A-Aea1dR7SX24JivlGVeUUvevaRjdLHZu0jxawm5N23IDprGdhCX2UiNuRCC_AsSQaUijA0g34AuxZwT1GaRQmvTyhBs1o7Nn2OzFmi0NH-OzXrubHtg-d6C301tpQ79823fZmebeq0p5B1WCa4ZoQN2u8EGvfAdIJnsAgxGfUjgeuNj-OeRX79Pl9s</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Laorden, M.L</creator><creator>Milanés, M.V</creator><creator>Chapleur-Château, M</creator><creator>Burlet, A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Changes in hypothalamic oxytocin levels during morphine tolerance</title><author>Laorden, M.L ; Milanés, M.V ; Chapleur-Château, M ; Burlet, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3649441d6a5f00349ef6c896ea50574954ee5d09c239d70dec4d28a4d83a1bd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Drug Tolerance - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Kinetics</topic><topic>Male</topic><topic>Median Eminence - metabolism</topic><topic>Morphine - pharmacology</topic><topic>Oxytocin - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reference Values</topic><topic>Supraoptic Nucleus - metabolism</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laorden, M.L</creatorcontrib><creatorcontrib>Milanés, M.V</creatorcontrib><creatorcontrib>Chapleur-Château, M</creatorcontrib><creatorcontrib>Burlet, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laorden, M.L</au><au>Milanés, M.V</au><au>Chapleur-Château, M</au><au>Burlet, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in hypothalamic oxytocin levels during morphine tolerance</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>31</volume><issue>2</issue><spage>143</spage><epage>146</epage><pages>143-146</pages><issn>0143-4179</issn><eissn>1532-2785</eissn><coden>NRPPDD</coden><abstract>The role of hypothalamic oxytocin neurons in the hypothalamus—pituitary—adrenal (HPA) axis adaptation during opioid tolerance has not been explored. In this study the modification of oxytocin levels in different hypothalamic nuclei was determined after acute or chronic morphine exposure. Male rats were implanted with placebo (naïve) or morphine (tolerant) pellets for 7 days. On day 8, groups of rats received an acute injection of either saline i.p. or morphine (30 mg/kg i.p.) and were sacrificed 30 min later. In morphine-tolerant rats, there was a decrease in the oxytocin content in the median eminence (ME) and in the supraoptic nucleus (SO) after acute injection of saline or morphine. No modifications were seen in the paraventricular nucleus (PVN). The present study demonstrates that chronic morphine administration alters the brain oxytocin system, which suggests that this peptide might contribute to the behavioural, emotional and neuroendocrine responses to opioids.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9179867</pmid><doi>10.1016/S0143-4179(97)90083-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Drug Tolerance - physiology Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Kinetics Male Median Eminence - metabolism Morphine - pharmacology Oxytocin - metabolism Paraventricular Hypothalamic Nucleus - metabolism Rats Rats, Sprague-Dawley Reference Values Supraoptic Nucleus - metabolism Time Factors Vertebrates: endocrinology |
| title | Changes in hypothalamic oxytocin levels during morphine tolerance |
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