Aromatase inhibition in hypophysectomised female rats: A novel animal model for in vivo screening

An experimental model for in vivo screening of aromatase inhibitors was developed which overcomes the interference of compounds centrally active via the pituitary-gonad axis. Mature female surgically or chemically hypophysectomised (hypx) rats were treated with the oestrogen precursor dehydroepiandr...

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Veröffentlicht in:	Journal of steroid biochemistry 1989-05, Vol.32 (5), p.625-631
Hauptverfasser:	Deckers, G.H., Schuurs, A.H.W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase Inhibitors Biological and medical sciences Dehydroepiandrosterone - metabolism Estradiol - blood Estrogens - biosynthesis Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Hypophysectomy Hypophysectomy, Chemical Mammalian female genital system Ovariectomy Rats Vagina - drug effects Vertebrates: reproduction
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