Cholinergic Stimulation Alters Performance and Task-Specific Regional Cerebral Blood Flow During Working Memory

Modulation of the cholinergic neurotransmitter system results in changes in memory performance, including working memory (WM), in animals and in patients with Alzheimer disease. To identify associated changes in the functional brain response, we studied performance measures and regional cerebral blo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-06, Vol.94 (12), p.6512-6516
Hauptverfasser:	Furey, M. L., Pietrini, P., Haxby, J. V., Alexander, G. E., Lee, H. C., VanMeter, J., Grady, C. L., Shetty, U., Rapoport, S. I., Schapiro, M. B., Freo, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Behavioral neuroscience Biological Sciences Blood flow Brain - blood supply Brain - diagnostic imaging Brain - physiology Cholinergics Cholinesterase Inhibitors - pharmacology Drug interactions Female Frontal Lobe - blood supply Frontal Lobe - drug effects Frontal Lobe - physiology Functional Laterality Humans Local maximum Male Memory Memory - drug effects Memory - physiology Middle Aged Physostigmine - pharmacology Positron emission tomography Prefrontal cortex Reaction Time - drug effects Reaction Time - physiology Reference Values Regional Blood Flow - drug effects Regression Analysis Tomography, Emission-Computed Visual cortex Working memory
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