Effects of altered dietary iron intake in Mycobacterium paratuberculosis-infected dairy cattle: sequential observations on growth, iron and copper metabolism and development of paratuberculosis
Twenty calves were orally inoculated with Mycobacterium paratuberculosis at six weeks old. At six months old, 10 of these, plus four uninfected controls were maintained on limited dietary copper and supplemented iron intake for a further 27 months. During this time all these animals, together with a...
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| Veröffentlicht in: | Research in veterinary science 1989-05, Vol.46 (3), p.289-296 |
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| creator | LEPPER, A.W.D. EMBURY, D.H. ANDERSON, D.A. LEWIS, V.M. |
| description | Twenty calves were orally inoculated with Mycobacterium paratuberculosis at six weeks old. At six months old, 10 of these, plus four uninfected controls were maintained on limited dietary copper and supplemented iron intake for a further 27 months. During this time all these animals, together with a further four untreated controls, were bred before being killed and examined for evidence of paratuberculosis. Despite significant reduction in weight gain, attributable to both iron supplementation and infection, no significant difference was found in the numbers of iron-supplemented and unsupplemented animals that developed clinical signs nor in the extent and severity of intestinal lesions between groups. Accumulation of iron in paratuberculosis lesions was not affected by iron supplementation but was positively correlated with the frequency of shedding of M paratuberculosis in faeces (P |
| doi_str_mv | 10.1016/S0034-5288(18)31168-8 |
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At six months old, 10 of these, plus four uninfected controls were maintained on limited dietary copper and supplemented iron intake for a further 27 months. During this time all these animals, together with a further four untreated controls, were bred before being killed and examined for evidence of paratuberculosis. Despite significant reduction in weight gain, attributable to both iron supplementation and infection, no significant difference was found in the numbers of iron-supplemented and unsupplemented animals that developed clinical signs nor in the extent and severity of intestinal lesions between groups. Accumulation of iron in paratuberculosis lesions was not affected by iron supplementation but was positively correlated with the frequency of shedding of M paratuberculosis in faeces (P<0·05). Dietary iron supplementation alone resulted in serum hyper-ferraemia, hepatic siderosis and slight hypocuprosis, whereas, in infected animals, this resulted in marked hypocuprosis and anaemia within groups (P<0·05). Infection alone resulted in serum hypoferraemia and intestinal and hepatic siderosis which was positively correlated with the severity of infection within groups (P<0·05). Susceptibility to paratuberculosis may result from failure ultimately to limit monokine-mediated iron sequestration in intestinal tissue.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)31168-8</identifier><identifier>PMID: 2740623</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anemia ; Animals ; Bacteria ; Body Weight ; Body weight gain ; Calves ; Cattle ; Cattle Diseases - blood ; Cattle Diseases - metabolism ; Cattle Diseases - microbiology ; Copper ; Copper - blood ; Copper - metabolism ; Diet ; Dietary intake ; Feed additives ; Female ; Infections ; Intestine ; Iron ; Iron - blood ; Iron - metabolism ; Lesions ; Metabolism ; Mycobacterium ; Paratuberculosis ; Siderosis ; Veterinary medicine ; Weight reduction</subject><ispartof>Research in veterinary science, 1989-05, Vol.46 (3), p.289-296</ispartof><rights>1989</rights><rights>Copyright Elsevier Limited May 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-b2a7096f77f35eb330a0c44caead1a68ac801b09f3636b06670b5cb2488c6b5d3</citedby><cites>FETCH-LOGICAL-c303t-b2a7096f77f35eb330a0c44caead1a68ac801b09f3636b06670b5cb2488c6b5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0034-5288(18)31168-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2740623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEPPER, A.W.D.</creatorcontrib><creatorcontrib>EMBURY, D.H.</creatorcontrib><creatorcontrib>ANDERSON, D.A.</creatorcontrib><creatorcontrib>LEWIS, V.M.</creatorcontrib><title>Effects of altered dietary iron intake in Mycobacterium paratuberculosis-infected dairy cattle: sequential observations on growth, iron and copper metabolism and development of paratuberculosis</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Twenty calves were orally inoculated with Mycobacterium paratuberculosis at six weeks old. At six months old, 10 of these, plus four uninfected controls were maintained on limited dietary copper and supplemented iron intake for a further 27 months. During this time all these animals, together with a further four untreated controls, were bred before being killed and examined for evidence of paratuberculosis. Despite significant reduction in weight gain, attributable to both iron supplementation and infection, no significant difference was found in the numbers of iron-supplemented and unsupplemented animals that developed clinical signs nor in the extent and severity of intestinal lesions between groups. Accumulation of iron in paratuberculosis lesions was not affected by iron supplementation but was positively correlated with the frequency of shedding of M paratuberculosis in faeces (P<0·05). Dietary iron supplementation alone resulted in serum hyper-ferraemia, hepatic siderosis and slight hypocuprosis, whereas, in infected animals, this resulted in marked hypocuprosis and anaemia within groups (P<0·05). Infection alone resulted in serum hypoferraemia and intestinal and hepatic siderosis which was positively correlated with the severity of infection within groups (P<0·05). Susceptibility to paratuberculosis may result from failure ultimately to limit monokine-mediated iron sequestration in intestinal tissue.</description><subject>Anemia</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Body Weight</subject><subject>Body weight gain</subject><subject>Calves</subject><subject>Cattle</subject><subject>Cattle Diseases - blood</subject><subject>Cattle Diseases - metabolism</subject><subject>Cattle Diseases - microbiology</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Copper - metabolism</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Feed additives</subject><subject>Female</subject><subject>Infections</subject><subject>Intestine</subject><subject>Iron</subject><subject>Iron - blood</subject><subject>Iron - metabolism</subject><subject>Lesions</subject><subject>Metabolism</subject><subject>Mycobacterium</subject><subject>Paratuberculosis</subject><subject>Siderosis</subject><subject>Veterinary medicine</subject><subject>Weight reduction</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEKtvCI1SyhISoRGAcx46XC0JV-SMVcQDOlu1MwCWxg-0s6uPxZji7qx564TSS5_vmG8-vqs4pvKJAxeuvAKyteSPlCyovGKVC1vJBtaGcNXUjBH1Ybe4kj6vTlG4AoKW0O6lOmq4F0bBN9fdqGNDmRMJA9JgxYk96h1nHW-Ji8MT5rH9hKeTzrQ1G26Jxy0RmHXVeDEa7jCG5VDu_Dlrt2hWz1TmP-IYk_L2gz06PJJiEcaezC77kefIjhj_558tDjvY9sWGeMZKpxJswujTtX3vc4RjmqUxZt7wf_KR6NOgx4dNjPau-v7_6dvmxvv7y4dPlu-vaMmC5No3uYCuGrhsYR8MYaLBtazXqnmohtZVADWwHJpgwIEQHhlvTtFJaYXjPzqrnh7lzDOVLKavJJYvjqD2GJaluC1xAy4vw2T3hTViiL7upBjjfFnhSFBU_qGwMKUUc1BzdVM6uKKgVsNoDVis9RaXaA1ay-M6P0xczYX_nOhIt_beHPpZb7BxGlaxDb7F3sfBRfXD_SfgH5g-60w</recordid><startdate>198905</startdate><enddate>198905</enddate><creator>LEPPER, A.W.D.</creator><creator>EMBURY, D.H.</creator><creator>ANDERSON, D.A.</creator><creator>LEWIS, V.M.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198905</creationdate><title>Effects of altered dietary iron intake in Mycobacterium paratuberculosis-infected dairy cattle: sequential observations on growth, iron and copper metabolism and development of paratuberculosis</title><author>LEPPER, A.W.D. ; EMBURY, D.H. ; ANDERSON, D.A. ; LEWIS, V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-b2a7096f77f35eb330a0c44caead1a68ac801b09f3636b06670b5cb2488c6b5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anemia</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Body Weight</topic><topic>Body weight gain</topic><topic>Calves</topic><topic>Cattle</topic><topic>Cattle Diseases - blood</topic><topic>Cattle Diseases - metabolism</topic><topic>Cattle Diseases - microbiology</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>Copper - metabolism</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Feed additives</topic><topic>Female</topic><topic>Infections</topic><topic>Intestine</topic><topic>Iron</topic><topic>Iron - blood</topic><topic>Iron - metabolism</topic><topic>Lesions</topic><topic>Metabolism</topic><topic>Mycobacterium</topic><topic>Paratuberculosis</topic><topic>Siderosis</topic><topic>Veterinary medicine</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEPPER, A.W.D.</creatorcontrib><creatorcontrib>EMBURY, D.H.</creatorcontrib><creatorcontrib>ANDERSON, D.A.</creatorcontrib><creatorcontrib>LEWIS, V.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEPPER, A.W.D.</au><au>EMBURY, D.H.</au><au>ANDERSON, D.A.</au><au>LEWIS, V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of altered dietary iron intake in Mycobacterium paratuberculosis-infected dairy cattle: sequential observations on growth, iron and copper metabolism and development of paratuberculosis</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1989-05</date><risdate>1989</risdate><volume>46</volume><issue>3</issue><spage>289</spage><epage>296</epage><pages>289-296</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Twenty calves were orally inoculated with Mycobacterium paratuberculosis at six weeks old. At six months old, 10 of these, plus four uninfected controls were maintained on limited dietary copper and supplemented iron intake for a further 27 months. During this time all these animals, together with a further four untreated controls, were bred before being killed and examined for evidence of paratuberculosis. Despite significant reduction in weight gain, attributable to both iron supplementation and infection, no significant difference was found in the numbers of iron-supplemented and unsupplemented animals that developed clinical signs nor in the extent and severity of intestinal lesions between groups. Accumulation of iron in paratuberculosis lesions was not affected by iron supplementation but was positively correlated with the frequency of shedding of M paratuberculosis in faeces (P<0·05). Dietary iron supplementation alone resulted in serum hyper-ferraemia, hepatic siderosis and slight hypocuprosis, whereas, in infected animals, this resulted in marked hypocuprosis and anaemia within groups (P<0·05). Infection alone resulted in serum hypoferraemia and intestinal and hepatic siderosis which was positively correlated with the severity of infection within groups (P<0·05). Susceptibility to paratuberculosis may result from failure ultimately to limit monokine-mediated iron sequestration in intestinal tissue.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>2740623</pmid><doi>10.1016/S0034-5288(18)31168-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 1989-05, Vol.46 (3), p.289-296 |
| issn | 0034-5288 1532-2661 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anemia Animals Bacteria Body Weight Body weight gain Calves Cattle Cattle Diseases - blood Cattle Diseases - metabolism Cattle Diseases - microbiology Copper Copper - blood Copper - metabolism Diet Dietary intake Feed additives Female Infections Intestine Iron Iron - blood Iron - metabolism Lesions Metabolism Mycobacterium Paratuberculosis Siderosis Veterinary medicine Weight reduction |
| title | Effects of altered dietary iron intake in Mycobacterium paratuberculosis-infected dairy cattle: sequential observations on growth, iron and copper metabolism and development of paratuberculosis |
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