Recent progress in understanding aldosterone secretion

1. 1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mec...

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Veröffentlicht in:General Pharmacology 1997-05, Vol.28 (5), p.647-651
Hauptverfasser: Foster, Richard H., MacFarlane, Catriona H., Bustamante, Mirta O.
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container_title General Pharmacology
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creator Foster, Richard H.
MacFarlane, Catriona H.
Bustamante, Mirta O.
description 1. 1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mechanisms. 3. 3. All effects on aldosterone secretion are initiated by an increase in Ca 2+ influx through hormone-operated Ca 2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP 3) and DAG that induce intracellular Ca 2+ release and PKC activation, respectively. 4. 4. ACTH increases DAG formation with marginal or undetectable IP 3 generation. The effect of ACTH on DAG levels is discussed. 5. 5. The requirement of external Ca 2+ in PLC activation and aldosterone secretion also is discussed.
doi_str_mv 10.1016/S0306-3623(96)00290-X
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The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mechanisms. 3. 3. All effects on aldosterone secretion are initiated by an increase in Ca 2+ influx through hormone-operated Ca 2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP 3) and DAG that induce intracellular Ca 2+ release and PKC activation, respectively. 4. 4. ACTH increases DAG formation with marginal or undetectable IP 3 generation. The effect of ACTH on DAG levels is discussed. 5. 5. 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The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mechanisms. 3. 3. All effects on aldosterone secretion are initiated by an increase in Ca 2+ influx through hormone-operated Ca 2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP 3) and DAG that induce intracellular Ca 2+ release and PKC activation, respectively. 4. 4. ACTH increases DAG formation with marginal or undetectable IP 3 generation. The effect of ACTH on DAG levels is discussed. 5. 5. 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The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mechanisms. 3. 3. All effects on aldosterone secretion are initiated by an increase in Ca 2+ influx through hormone-operated Ca 2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP 3) and DAG that induce intracellular Ca 2+ release and PKC activation, respectively. 4. 4. ACTH increases DAG formation with marginal or undetectable IP 3 generation. The effect of ACTH on DAG levels is discussed. 5. 5. 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subjects Adrenal cortex
Adrenal Cortex - metabolism
Adrenal Cortex - physiology
Adrenals. Interrenals
Adrenocortical hormones. Regulation
Adrenocorticotropic Hormone - physiology
aldosterone
Aldosterone - biosynthesis
Aldosterone - metabolism
Angiotensin II - metabolism
Animals
Biological and medical sciences
Calcium - metabolism
Cyclic AMP - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Phospholipids - metabolism
Potassium - metabolism
steroidogenesis
Vertebrates: endocrinology
title Recent progress in understanding aldosterone secretion
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