Recent progress in understanding aldosterone secretion
1. 1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K +). 2. 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca 2+-dependent mec...
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Veröffentlicht in: | General Pharmacology 1997-05, Vol.28 (5), p.647-651 |
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container_title | General Pharmacology |
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creator | Foster, Richard H. MacFarlane, Catriona H. Bustamante, Mirta O. |
description | 1.
1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K
+).
2.
2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca
2+-dependent mechanisms.
3.
3. All effects on aldosterone secretion are initiated by an increase in Ca
2+ influx through hormone-operated Ca
2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP
3) and DAG that induce intracellular Ca
2+ release and PKC activation, respectively.
4.
4. ACTH increases DAG formation with marginal or undetectable IP
3 generation. The effect of ACTH on DAG levels is discussed.
5.
5. The requirement of external Ca
2+ in PLC activation and aldosterone secretion also is discussed. |
doi_str_mv | 10.1016/S0306-3623(96)00290-X |
format | Article |
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1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K
+).
2.
2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca
2+-dependent mechanisms.
3.
3. All effects on aldosterone secretion are initiated by an increase in Ca
2+ influx through hormone-operated Ca
2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP
3) and DAG that induce intracellular Ca
2+ release and PKC activation, respectively.
4.
4. ACTH increases DAG formation with marginal or undetectable IP
3 generation. The effect of ACTH on DAG levels is discussed.
5.
5. The requirement of external Ca
2+ in PLC activation and aldosterone secretion also is discussed.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/S0306-3623(96)00290-X</identifier><identifier>PMID: 9184796</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenal cortex ; Adrenal Cortex - metabolism ; Adrenal Cortex - physiology ; Adrenals. Interrenals ; Adrenocortical hormones. Regulation ; Adrenocorticotropic Hormone - physiology ; aldosterone ; Aldosterone - biosynthesis ; Aldosterone - metabolism ; Angiotensin II - metabolism ; Animals ; Biological and medical sciences ; Calcium - metabolism ; Cyclic AMP - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Phospholipids - metabolism ; Potassium - metabolism ; steroidogenesis ; Vertebrates: endocrinology</subject><ispartof>General Pharmacology, 1997-05, Vol.28 (5), p.647-651</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-e2e842c4663702991416e70be00796636aaed3faa03fb0a7f0353cdcd8ec82c73</citedby><cites>FETCH-LOGICAL-c389t-e2e842c4663702991416e70be00796636aaed3faa03fb0a7f0353cdcd8ec82c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>313,314,778,782,790,27905,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2697025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9184796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foster, Richard H.</creatorcontrib><creatorcontrib>MacFarlane, Catriona H.</creatorcontrib><creatorcontrib>Bustamante, Mirta O.</creatorcontrib><title>Recent progress in understanding aldosterone secretion</title><title>General Pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K
+).
2.
2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca
2+-dependent mechanisms.
3.
3. All effects on aldosterone secretion are initiated by an increase in Ca
2+ influx through hormone-operated Ca
2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP
3) and DAG that induce intracellular Ca
2+ release and PKC activation, respectively.
4.
4. ACTH increases DAG formation with marginal or undetectable IP
3 generation. The effect of ACTH on DAG levels is discussed.
5.
5. The requirement of external Ca
2+ in PLC activation and aldosterone secretion also is discussed.</description><subject>Adrenal cortex</subject><subject>Adrenal Cortex - metabolism</subject><subject>Adrenal Cortex - physiology</subject><subject>Adrenals. Interrenals</subject><subject>Adrenocortical hormones. Regulation</subject><subject>Adrenocorticotropic Hormone - physiology</subject><subject>aldosterone</subject><subject>Aldosterone - biosynthesis</subject><subject>Aldosterone - metabolism</subject><subject>Angiotensin II - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Phospholipids - metabolism</subject><subject>Potassium - metabolism</subject><subject>steroidogenesis</subject><subject>Vertebrates: endocrinology</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QmEPInpYnWx2s5uTSPELCoIf0FtIk9kS2WY12RX896bt0qunOcwzM-88hEwpXFOg_OYNGPCU8YxdCn4FkAlIFwdkTKtSpACUHpLxHjkmJyF8QqSKLBuRkaBVXgo-JvwVNbou-fLtymMIiXVJ7wz60ClnrFslqjFt6NC3DpOA2mNnW3dKjmrVBDwb6oR8PNy_z57S-cvj8-xunmpWiS7FDKs80znnrIwBBc0pxxKWCBCvc8aVQsNqpYDVS1BlDaxg2mhToa4yXbIJudjtjfm-ewydXNugsWmUw7YPshRQFKyoIljsQO3bEDzW8svbtfK_koLc-JJbX3IjQwout77kIs5NhwP9co1mPzUIiv3zoa-CVk3tldM27LGMi_hYEbHbHYZRxo9FL4O26DQa61F30rT2nyB_QuOG_w</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Foster, Richard H.</creator><creator>MacFarlane, Catriona H.</creator><creator>Bustamante, Mirta O.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Recent progress in understanding aldosterone secretion</title><author>Foster, Richard H. ; MacFarlane, Catriona H. ; Bustamante, Mirta O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-e2e842c4663702991416e70be00796636aaed3faa03fb0a7f0353cdcd8ec82c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenal cortex</topic><topic>Adrenal Cortex - metabolism</topic><topic>Adrenal Cortex - physiology</topic><topic>Adrenals. Interrenals</topic><topic>Adrenocortical hormones. Regulation</topic><topic>Adrenocorticotropic Hormone - physiology</topic><topic>aldosterone</topic><topic>Aldosterone - biosynthesis</topic><topic>Aldosterone - metabolism</topic><topic>Angiotensin II - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Phospholipids - metabolism</topic><topic>Potassium - metabolism</topic><topic>steroidogenesis</topic><topic>Vertebrates: endocrinology</topic><toplevel>online_resources</toplevel><creatorcontrib>Foster, Richard H.</creatorcontrib><creatorcontrib>MacFarlane, Catriona H.</creatorcontrib><creatorcontrib>Bustamante, Mirta O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, Richard H.</au><au>MacFarlane, Catriona H.</au><au>Bustamante, Mirta O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent progress in understanding aldosterone secretion</atitle><jtitle>General Pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>28</volume><issue>5</issue><spage>647</spage><epage>651</epage><pages>647-651</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K
+).
2.
2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca
2+-dependent mechanisms.
3.
3. All effects on aldosterone secretion are initiated by an increase in Ca
2+ influx through hormone-operated Ca
2+ channels and G-protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP
3) and DAG that induce intracellular Ca
2+ release and PKC activation, respectively.
4.
4. ACTH increases DAG formation with marginal or undetectable IP
3 generation. The effect of ACTH on DAG levels is discussed.
5.
5. The requirement of external Ca
2+ in PLC activation and aldosterone secretion also is discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9184796</pmid><doi>10.1016/S0306-3623(96)00290-X</doi><tpages>5</tpages></addata></record> |
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subjects | Adrenal cortex Adrenal Cortex - metabolism Adrenal Cortex - physiology Adrenals. Interrenals Adrenocortical hormones. Regulation Adrenocorticotropic Hormone - physiology aldosterone Aldosterone - biosynthesis Aldosterone - metabolism Angiotensin II - metabolism Animals Biological and medical sciences Calcium - metabolism Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Humans Phospholipids - metabolism Potassium - metabolism steroidogenesis Vertebrates: endocrinology |
title | Recent progress in understanding aldosterone secretion |
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