Stereoselective inhibition of rat brain cyclooxygenase by dexketoprofen

Although it has been assumed that the effects of nonsteroidal antiinflammatory drugs (NSAIDs) are mainly the result of their action on local synthesis of prostaglandins, there is growing evidence to suggest that they may also exert a central analgesic action. Some authors have suggested that inhibit...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1997, Vol.9 (3), p.281-285
Hauptverfasser:	Carabaza, Assumpta, Cabré, Francesc, García, Ana M., Rotllan, Elisabet, García, M. Luisa, Mauleón, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain Brain - drug effects Brain - enzymology Brain Chemistry - drug effects cyclooxygenase Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology dexketoprofen Dinoprost - metabolism enantiomer In Vitro Techniques Ketoprofen - chemistry Ketoprofen - pharmacology Male Microsomes - drug effects Microsomes - enzymology Prostaglandin-Endoperoxide Synthases - chemistry rat Rats Rats, Sprague-Dawley Stereoisomerism stereoselectivity
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