Effect of dexamethasone on voltage-gated Ca2+ channels and cytosolic Ca2+ in rat chromaffin cells

THE present study examined whether the synthetic glucocorticoid dexamethasone (DEX) can modulate voltage-gated Ca channel (VGCC) activity, and as a consequence agonist-induced increases in cytosolic Ca, in cultured rat adrenal medullary chromaffin (RAMC) cells. Exposure to 1 μM DEX for 48 h signific...

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Veröffentlicht in:	Neuroreport 1997-03, Vol.8 (5), p.1169-1172
Hauptverfasser:	Fuller, Lynn, Lu, Chengbiao, McMahon, Douglas, Alaudin, Elora, Jorgensen, Mark, Rau, Shane, Sisken, Jesse, Jackson, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Biological and medical sciences Calcium Channel Agonists - pharmacology Calcium Channels - drug effects Cells, Cultured Chromaffin Cells - drug effects Chromaffin Cells - metabolism Cytosol - drug effects Cytosol - metabolism Dexamethasone - pharmacology Fundamental and applied biological sciences. Psychology Glucocorticoids Ion Channel Gating - drug effects Male Patch-Clamp Techniques Rats Rats, Sprague-Dawley Vertebrates: endocrinology
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