Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma
A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1989-01, Vol.227 (3), p.291-294 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 227 |
| creator | SCHALING, D. F VAN KROONENBURGH, M. J. P. G BORSJE, R. A CAMPUS, J. A. J KAKEBEEKE-KEMME, H. M OOSTERHUIS, J. A PAUWELS, E. K. J |
| description | A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed. |
| doi_str_mv | 10.1007/BF02172765 |
| format | Article |
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F ; VAN KROONENBURGH, M. J. P. G ; BORSJE, R. A ; CAMPUS, J. A. J ; KAKEBEEKE-KEMME, H. M ; OOSTERHUIS, J. A ; PAUWELS, E. K. J</creator><creatorcontrib>SCHALING, D. F ; VAN KROONENBURGH, M. J. P. G ; BORSJE, R. A ; CAMPUS, J. A. J ; KAKEBEEKE-KEMME, H. M ; OOSTERHUIS, J. A ; PAUWELS, E. K. J</creatorcontrib><description>A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/BF02172765</identifier><identifier>PMID: 2500385</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Antibodies, Monoclonal ; Biological and medical sciences ; Choroid Neoplasms - diagnostic imaging ; Female ; Humans ; Hypersensitivity - immunology ; Injections, Intravenous ; Male ; Medical sciences ; Melanoma - diagnostic imaging ; Middle Aged ; Ophthalmology ; Pilot Projects ; Prospective Studies ; Radionuclide Imaging ; Skin Neoplasms - immunology ; Skin Tests ; Time Factors ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus ; Whole-Body Counting</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 1989-01, Vol.227 (3), p.291-294</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-65c24ceb4f06580ab66fe6143defb8d956e5ecf70e1b56632eb7c5ee86a59b7b3</citedby><cites>FETCH-LOGICAL-c311t-65c24ceb4f06580ab66fe6143defb8d956e5ecf70e1b56632eb7c5ee86a59b7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7212621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2500385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHALING, D. F</creatorcontrib><creatorcontrib>VAN KROONENBURGH, M. J. P. G</creatorcontrib><creatorcontrib>BORSJE, R. A</creatorcontrib><creatorcontrib>CAMPUS, J. A. J</creatorcontrib><creatorcontrib>KAKEBEEKE-KEMME, H. M</creatorcontrib><creatorcontrib>OOSTERHUIS, J. A</creatorcontrib><creatorcontrib>PAUWELS, E. K. J</creatorcontrib><title>Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Choroid Neoplasms - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Skin Neoplasms - immunology</subject><subject>Skin Tests</subject><subject>Time Factors</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><subject>Whole-Body Counting</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1LAzEQhoMotVYv3oU9iAdhNR-bZHvUYlUoCKLQ25JkZ9vIJqmbXaT_3kirnubwPjPMPIPQOcE3BGN5ez_HlEgqBT9AY1IwnktMl4dojCUlecno8hidxPiBMU4hGaER5Rizko9R_apqG6xzgw_RWN_bVac26232Zft15qBVPjiVqxiDsaqHOnPBB9MGr9pMJVyHeps1nVo58H3MrM_MOnTB1in_bT9FR41qI5zt6wS9zx_eZk_54uXxeXa3yA0jpM8FN7QwoIsGC15ipYVoQKR7amh0WU-5AA6mkRiI5kIwCloaDlAKxadaajZBV7u5my58DhD7ytlooE1bQBhiJaeYE86KBF7vQNOFGDtoqk1nneq2FcHVj9LqX2mCL_ZTB-2g_kP3DlN-uc9VNKpNLryx8Q9LL6CCEvYN4QCAeg</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>SCHALING, D. 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F</creatorcontrib><creatorcontrib>VAN KROONENBURGH, M. J. P. G</creatorcontrib><creatorcontrib>BORSJE, R. A</creatorcontrib><creatorcontrib>CAMPUS, J. A. J</creatorcontrib><creatorcontrib>KAKEBEEKE-KEMME, H. M</creatorcontrib><creatorcontrib>OOSTERHUIS, J. A</creatorcontrib><creatorcontrib>PAUWELS, E. K. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHALING, D. F</au><au>VAN KROONENBURGH, M. J. P. G</au><au>BORSJE, R. A</au><au>CAMPUS, J. A. J</au><au>KAKEBEEKE-KEMME, H. M</au><au>OOSTERHUIS, J. A</au><au>PAUWELS, E. K. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>227</volume><issue>3</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><coden>GACODL</coden><abstract>A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2500385</pmid><doi>10.1007/BF02172765</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1989-01, Vol.227 (3), p.291-294 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Antibodies, Monoclonal Biological and medical sciences Choroid Neoplasms - diagnostic imaging Female Humans Hypersensitivity - immunology Injections, Intravenous Male Medical sciences Melanoma - diagnostic imaging Middle Aged Ophthalmology Pilot Projects Prospective Studies Radionuclide Imaging Skin Neoplasms - immunology Skin Tests Time Factors Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Whole-Body Counting |
| title | Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma |
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