Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat
When sodium nitroprusside in artificial medium was perfused through the isolated liver and hindlimbs of a rat at the near physiological flow rate of 8.5 ml min −1, free cyanide was found in the perfusate. The liver reached a steady-state ratio of cyanide released/nitroprus-side perfused of about 1.5...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1989-06, Vol.99 (2), p.354-356 |
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| container_title | Toxicology and applied pharmacology |
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| creator | Devlin, Dennis J. Smith, Roger P. Thron, C.Dennis |
| description | When sodium nitroprusside in artificial medium was perfused through the isolated liver and hindlimbs of a rat at the near physiological flow rate of 8.5 ml min
−1, free cyanide was found in the perfusate. The liver reached a steady-state ratio of cyanide released/nitroprus-side perfused of about 1.5 (or approximately 30% of the total nitroprusside cyanide) within 15 min, and maintained that rate for about 1.5 hr. In the hindlimbs cyanide was released at a much slower rate (7.5 to 18.8% of the total), and the release did not achieve a steady state even after 1.5 hr. Even after small corrections for cyanide extraction by both tissues, the rate of cyanide release by either tissue was probably more rapid than that resulting from static incubations in blood. |
| doi_str_mv | 10.1016/0041-008X(89)90017-3 |
| format | Article |
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−1, free cyanide was found in the perfusate. The liver reached a steady-state ratio of cyanide released/nitroprus-side perfused of about 1.5 (or approximately 30% of the total nitroprusside cyanide) within 15 min, and maintained that rate for about 1.5 hr. In the hindlimbs cyanide was released at a much slower rate (7.5 to 18.8% of the total), and the release did not achieve a steady state even after 1.5 hr. Even after small corrections for cyanide extraction by both tissues, the rate of cyanide release by either tissue was probably more rapid than that resulting from static incubations in blood.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Cyanides - metabolism</subject><subject>Female</subject><subject>Ferricyanides - metabolism</subject><subject>Hindlimb</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Muscles - metabolism</subject><subject>Nitroprusside - metabolism</subject><subject>Perfusion</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-L1TAUxYMo45vRb6CQhYiC1ZsmTZqNII_xDwy4mYW7kCY3TCRtnkk7MN_edt7jLXWTGzi_cxLOJeQVg48MmPwEIFgD0P961-v3GoCphj8hOwZaNsA5f0p2Z-Q5uaz1NwBoIdgFuWgVF0rLHQn7BztFj7RgQluRhpJHOsW55ENZat2kONH5bh01Jzuj_0APWMJSt9uQcvYJa6Up3mOhdvL0Lk4-xXGoNIdHY7HzC_Is2FTx5Wlekduv17f7783Nz28_9l9uGieYmtez58x22g0CgpLQS6WDR67BtihFKwbZ8c47lIMSXnreAZed1ipIrbziV-TtMfZQ8p8F62zGWB2mZCfMSzVKg9BKt_8F2fqMahlfQXEEXcm1FgzmUOJoy4NhYLY1mK1js3Vsem0e12A22-tT_jKM6M-mU--r_uak2-psCsVOLtYzpngrQG4xn48Yrp3dRyymuoiTQx8Lutn4HP_9j7_jRKNu</recordid><startdate>19890615</startdate><enddate>19890615</enddate><creator>Devlin, Dennis J.</creator><creator>Smith, Roger P.</creator><creator>Thron, C.Dennis</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19890615</creationdate><title>Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat</title><author>Devlin, Dennis J. ; Smith, Roger P. ; Thron, C.Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c4831a59cb40f7608679fde390a2e6424b6535dce6b74d6d350365997f697d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Cyanides - metabolism</topic><topic>Female</topic><topic>Ferricyanides - metabolism</topic><topic>Hindlimb</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Muscles - metabolism</topic><topic>Nitroprusside - metabolism</topic><topic>Perfusion</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devlin, Dennis J.</creatorcontrib><creatorcontrib>Smith, Roger P.</creatorcontrib><creatorcontrib>Thron, C.Dennis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devlin, Dennis J.</au><au>Smith, Roger P.</au><au>Thron, C.Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1989-06-15</date><risdate>1989</risdate><volume>99</volume><issue>2</issue><spage>354</spage><epage>356</epage><pages>354-356</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>When sodium nitroprusside in artificial medium was perfused through the isolated liver and hindlimbs of a rat at the near physiological flow rate of 8.5 ml min
−1, free cyanide was found in the perfusate. The liver reached a steady-state ratio of cyanide released/nitroprus-side perfused of about 1.5 (or approximately 30% of the total nitroprusside cyanide) within 15 min, and maintained that rate for about 1.5 hr. In the hindlimbs cyanide was released at a much slower rate (7.5 to 18.8% of the total), and the release did not achieve a steady state even after 1.5 hr. Even after small corrections for cyanide extraction by both tissues, the rate of cyanide release by either tissue was probably more rapid than that resulting from static incubations in blood.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2734796</pmid><doi>10.1016/0041-008X(89)90017-3</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicology and applied pharmacology, 1989-06, Vol.99 (2), p.354-356 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79049792 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cardiovascular system Cyanides - metabolism Female Ferricyanides - metabolism Hindlimb Liver - metabolism Medical sciences Miscellaneous Muscles - metabolism Nitroprusside - metabolism Perfusion Pharmacology. Drug treatments Rats |
| title | Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat |
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